y - JOUR A2 - Perez-Lopez, fastino R. AU - Cevigney, Rachel AU - Leary, Christopher AU - Gonik，伯纳德PY - 2021 DA - 2021/05/25 TI -可调算法工具评估的有效性孕产妇呼吸道合胞病毒(RSV)疫苗在发展中国家的婴儿死亡率SP - 5536633六世- 2021 AB -急性下呼吸道感染(所)由于RSV是全球婴儿死亡率的常见原因,大多数病例发生在发展中国家。利用由美国国际开发署(USAID)孕产妇儿童健康与营养(MCHN)项目指定的重点国家汇总的数据，我们创建了一个可调整的算法工具，以可视化孕产妇RSV候选疫苗对婴儿死亡率的效果。国别疾病负担和病死率估计数是根据既定数据计算的。根据报告的0-59个月儿童发病率，对0-5个月婴儿的国家特定RSV-ALRI发病率进行分级。利用住院死亡率和预先确定的“通货膨胀因素”，我们估计了0-5个月婴儿的死亡率。考虑到一项候选产妇疫苗接种计划的实施，估计婴儿RSV-ALRI发病率和死亡率的下降。用户输入用于确定计划的覆盖范围和疫苗的效力。使用生成的算法，婴儿死亡率的总体下降幅度因疫苗的效力和分布而有很大差异。 Given a potential efficacy of 70% and a maternal distribution rate of 50% in every USAID MCHN priority country, annual RSV-ALRI-related infant mortality is estimated to be reduced by 14,862 cases. The absolute country-specific reduction is dependent on the number of live births; countries with the highest birth rates had the greatest impact on annual mortality reduction. The adjustable algorithm provides a standardized analytical tool in the evaluation of candidate maternal RSV vaccines. Ultimately, it can be used to guide public health initiatives, research funding, and policy implementation concerning the effectiveness of potential maternal RSV vaccination on reducing infant mortality. SN - 1064-7449 UR - https://doi.org/10.1155/2021/5536633 DO - 10.1155/2021/5536633 JF - Infectious Diseases in Obstetrics and Gynecology PB - Hindawi KW - ER -