TY -的A2 Gionchetti保罗AU -赖,Hsiang-Chun AU - Chang Chia-Hsi AU - Cheng Ken-Sheng AU - Chen Tsung-Wei盟——蔡Yuan-Yao盟——周Jen-Wei PY - 2019 DA - 2019/11/03 TI - QuantiFERON-TB黄金测试转换与活动性结核病患者炎症性肠病发展生物制剂:台湾的一个医疗中心的经验SP - 7132875 VL - 2019 AB -台湾的炎症性肠病(IBD)的患病率低于西方国家,肺结核(TB)的患病率高于西方国家。本研究的目的是调查潜伏期结核病(LTB)和活动性结核病感染在IBD患者接受生物制剂治疗的患病率。2000年1月至2018年9月,我们回顾性收集了三级转诊中心使用生物制剂治疗的IBD患者的数据。患者接受了定量结核病金试验(QFT),以筛查生物治疗前后的结核病感染情况。分析诊断年龄、性别、体重指数、乙肝病毒感染、生化特征、治疗方案和QFT结果。总共有130名接受生物治疗的IBD患者被纳入研究。测定120例患者(92%)生物治疗前的QFT结果;其中10例为阳性(8%),110例为阴性(85%),10例为不确定(9%)。6名患者在生物治疗后表现出血清转化,这是由QFT确定的。 Three patients (2.4%) developed active pulmonary TB after biological treatment. In subgroup analysis, the positive QFT patients had a trend of lower baseline serum C-reactive protein and erythrocyte sedimentation rate levels than the negative QFT group. The present study demonstrates that the prevalence of LTB before and after biological treatment is higher in Taiwan than in most Western countries and similar to other Asian countries. Therefore, screening and monitoring of TB infection are necessary for IBD patients before and during biological treatments in Taiwan. SN - 1687-6121 UR - https://doi.org/10.1155/2019/7132875 DO - 10.1155/2019/7132875 JF - Gastroenterology Research and Practice PB - Hindawi KW - ER -