TY - JOUR A2 - 卡斯特，A. AU - Khediri，Faouzi AU - 拉德，Abdennebi Ilhem AU - Azzouz，Moussadek AU - Doughi，赫迪拉AU - 纳贾尔，陶菲克AU - Mathiex-Fortunet，海伦AU - 卡尼尔，菲利普AU - 科尔托安托万PY - 2011 DA - 2011/06/30 TI - 功效Diosmectite的（的思密达）^®在急性腹泻的治疗成人的多中心，随机，双盲，安慰剂对照，平行组研究SP - 783196 VL - 2011 AB - 背景。虽然diosmectite已经证明儿童急性水样腹泻的治疗效果，其疗效的成年人还需要进行评估。因此，这项研究的目的是评估在急性腹泻大人的时间来恢复diosmectite的功效。 方法。A total of 346 adults with at least three watery stools per day over a period of less than 48 hours were prospectively randomized to diosmectite (6 g tid) or placebo during four days. The primary endpoint was time to diarrhoea recovery. 结果。在意向治疗群体中位恢复时间为53.8小时（范围[3.7-167.3]）与diosmectite（ ñ = 166 ）对69.0小时[2.2-165.2]与安慰剂，（ ñ = 163 ; P = .029 ），其对应于15.2小时差异。Diosmectite的耐受性良好。 结论。Diosmectite at 6 g tid was well tolerated and reduced the time to recovery of acute watery diarrhoea episode in a clinically relevant manner. SN - 1687-6121 UR - https://doi.org/10.1155/2011/783196 DO - 10.1155/2011/783196 JF - Gastroenterology Research and Practice PB - Hindawi Publishing Corporation KW - ER -