TY - JOUR A2 - 泽井，Hirozumi AU - 巴什布，穆拉特AU - Bulbuller，Nurullah AU - Camci，Cemalettin AU - Ayten，Refik AU - Aygen，埃尔汗AU - Ozercan，易卜拉欣Hanifi AU - Arikanoglu，Zulfu AU - 布卢特，萨米PY- 2011 DA - 2011/06/28 TI - 抗血管内皮生长因子对粘连形成的发展的影响剖腹鼠：实验研究SP - 578691 VL - 2011 AB - 宗旨。本研究确定贝伐单抗的单次剂量，即特异性地靶向血管内皮生长因子（VEGF）抗血管生成的重组单克隆抗体的效果，对大鼠盲肠模型磨损粘连形成。 方法。Thirty female Wistar albino rats (200–224 g) were divided into three groups. All rats underwent laparotomy at which time cecal wall abrasion and abdominal wall injuries were induced. Group I (control) underwent only the abrasion procedure; Groups II and III received saline or bevacizumab intraperitoneally, respectively, following the abrasion. The rats were killed on postoperative day 7, and the severity of adhesions was evaluated, together with histopathological fibrosis parameters and immunohistochemical staining to identify the VEGF receptor. 结果。平均粘连严重度评分在组I-III是 2.5 ± 0.52 ， 2.4 ± 0.69 和 0.7 ± 0.82 ， 分别;在第三组的成绩比团体我显著降低（ P < 0.001 ）和II（ P < 0.001 ）。在组织病理学评估，平均纤维化评分在第三组是显著比分数在组I（ P < 0.001 ）和II（ P < 0.001 ）。VEGF染色Ⅲ族粘合区域的显着高于Ⅰ类显著降低（ P < 0.001 ）和II（ P < 0.001 ）。 结论。贝伐单抗减少粘连形成通过阻断VEGF受体占有率以下大鼠剖腹手术。SN - 1687-6121 UR - https://doi.org/10.1155/2011/578691 DO - 10.1155 /五十七万八千六百九十一分之二千○一十一JF - 消化内科的研究与实践PB - Hindawi出版公司公司KW - ER -