TY - JOUR A2 - Chen, Wen-Jone AU - Saeb, Aya AU - Hagglund, Karen H. AU - Cigolle, Christine T. PY - 2016 DA - 2016/02/03 TI - Using Fresh Frozen Plasma for Acute Airway Angioedema to Prevent Intubation in the Emergency Department: A Retrospective Cohort Study SP - 6091510 VL - 2016 AB - Background。Angioedema (AE) is a common condition which can be complicated by laryngeal edema, having up to 40% mortality. Although sporadic case reports attest to the benefits of fresh frozen plasma (FFP) in treating severe acute bouts of AE, little evidence-based support for this practice is available at present. Study Objectives。对compare the frequency, duration of intubation, and length of intensive care unit (ICU) stay in patients with acute airway AE, with and without the use of FFP. Methods。A retrospective cohort study was conducted, investigating adults admitted to large community hospital ICU with a diagnosis of AE during the years of 2007–2012. Altogether, 128 charts were reviewed for demographics, comorbidities, hospital courses, and outcomes. A total of 20 patients received FFP (108 did not). Results。Demographics and comorbidities did not differ by treatment group. However, nontreated controls did worse in terms of intubation frequency (60% versus 35%; p = 0.05 )和ICU停留(3.5和1.5天; p < 0.001 ). Group outcomes were otherwise similar. Conclusion。In an emergency department setting, the use of FFP should be considered in managing acute airway nonhereditary AE (refractory to steroid, antihistamine, and epinephrine). Larger prospective, better controlled studies are needed to devise appropriate treatment guidelines. SN - 2090-2840 UR - https://doi.org/10.1155/2016/6091510 DO - 10.1155/2016/6091510 JF - Emergency Medicine International PB - Hindawi Publishing Corporation KW - ER -