TY -的A2 - Tan Songwen盟——梁、回族盟——徐Congjie AU -胡,广州市AU -温,帮派AU -林,杰盟——刘道盟——徐Jiyi PY - 2021 DA - 2021/09/07 TI -重复经颅磁刺激改善神经病变和实验性脑梗死大鼠氧化应激水平通过Nrf2信号通路SP - 3908677六世- 2021 AB -缺血性中风对人类健康构成了严重的威胁。其高发病率、残疾和杀伤力利率导致它成为一个研究热点。脑缺血再灌注损伤是治疗缺血性中风的难点。近年来,研究表明,重复经颅磁刺激(rTMS)可以增强脑缺血性宽容和对缺血后再灌注损伤有显著的保护作用,但其具体机制尚不清楚。Nrf2 /通路在缺血再灌注损伤中起着至关重要的作用在体内环境。因此,在这个实验中,大脑中动脉闭塞(MCAO)再灌注模型的SD大鼠实验性脑梗死的发生进行了数值模拟的缝合方法。rTMS治疗后,研究了是否能调节的表达Nrf2 HO-1,影响MDA的含量和SOD活性,然后激活Nrf2通路发挥脑保护。结果表明,MCAO再灌注后,大鼠的神经功能缺损评分增加,和时间消除双边贴纸和时间交叉平衡木增加,表明实验的成功建立脑梗死模型。检测实验脑梗塞大鼠的脑组织发现Nrf2的表达和HO-1下降,MDA含量增加,SOD酶活性降低。rTMS治疗后,实验性脑梗塞大鼠的神经运动的功能改善,Nrf2和HO-1脑组织的表达逐渐增加,MDA含量降低,SOD的活性增加。 It indicates that the expression of Nrf2 and HO-1 in experimental cerebral infarction rats is reduced. After treatment with rTMS, it can improve the neuromotor function damage of the rats and reduce the level of oxidative stress. The mechanism may be through promoting the activation of the Nrf2 signaling pathway, acting on the expression of antioxidant proteins, such as HO-1 and SOD1, reducing oxidative stress damage, and playing a protective effect on brain tissue. SN - 1741-427X UR - https://doi.org/10.1155/2021/3908677 DO - 10.1155/2021/3908677 JF - Evidence-Based Complementary and Alternative Medicine PB - Hindawi KW - ER -