TY - JOUR A2 - Wang, Jing-Hua AU - Guo, Yi AU - Li, Jun-xiang AU - Wang, Yun-liang AU - Mao, Tang-you AU - Chen, Chen AU - Xie, Tian-hong AU - Han, Ya-fei AU - Tan, Xiang AU - Han，AB - Yinchen灵桂助肝汤(YCLGZGD)是灵桂助肝(LGZGD)和银辰好(YCHD)煎剂的结合，两个著名的中药处方。在前期研究中，我们发现银陈灵桂助肝汤(YCLGZGD)在非酒精性脂肪性肝病(NAFLD)病理过程中可调节脂质代谢紊乱，减轻炎症反应。然而，确切的潜在机制仍然未知。本研究旨在探讨银陈灵桂助肝汤对高脂饲料大鼠实验性NAFLD的影响及其机制。每日给药YCLGZGD、LGZGD和YCHD，持续4周，之后对大鼠实施安乐死。测定血脂、肝酶、H&E和Oil Red O染色水平，评价NAFLD严重程度。Western blotting和real-time polymerase chain reaction分别检测Keap1、Nrf2、NQO1和HO-1的肝脏蛋白和基因表达。口服YCLGZGD可改善hfd诱导的NAFLD。 Furthermore, YCLGZGD increased the protein and gene expression of Nrf2, NQO1, and HO-1 without changing Keap1. Overall, these results suggest that YCLGZGD ameliorates HFD-induced NAFLD in rats by upregulating the Nrf2/ARE signaling pathway. SN - 1741-427X UR - https://doi.org/10.1155/2017/6178358 DO - 10.1155/2017/6178358 JF - Evidence-Based Complementary and Alternative Medicine PB - Hindawi KW - ER -