TY -的A2 Thounaojam Menaka c . AU -张,燕盟- Wang Ping盟——徐Youdong盟——孟Xianli盟——张易PY - 2016 DA - 2016/03/03 TI -代谢组学分析生物化学变化的高脂肪饮食的等离子体和体外实验糖尿病大鼠治疗后的葛根异黄酮提取SP - 4701890六世- 2016 AB -本研究的主要目的是调查从葛根总异黄酮的保护作用(PTIF)在糖尿病大鼠。糖尿病是由高脂饮食诱导和腹腔内注射小剂量链脲霉素(STZ);40毫克/公斤)。在26周开始,PTIF 421毫克/公斤是管理老鼠每天一次连续10周。代谢分析变化分析Ultraperformance液体Chromatography-Quadrupole-Exactive Orbitrap-Mass谱(UPLC-Q-Exactive Orbitrap-MS)。主成分判别分析(PCA-DA)偏最小二乘判别分析(PLS-DA)和正交偏最小二乘判别分析(OPLS-DA)是用于多变量分析。此外,血清中游离氨基酸测定高效液相色谱法和荧光检测器(HPLC-FLD)。此外,氧化应激和炎症细胞因子进行评估。十一个潜在代谢物生物标志物,这主要与凝血、脂质代谢、氨基酸代谢、已确定。PCA-DA分数情节表明生化变化在糖尿病大鼠PTIF管理后逐渐恢复正常。 Furthermore, the levels of BCAAs, glutamate, arginine, and tyrosine were significantly increased in diabetic rats. Treatment with PTIF could regulate the disturbed amino acid metabolism. Consequently, PTIF has great therapeutic potential in the treatment of DM by improving metabolism disorders and inhibiting oxidative damage. SN - 1741-427X UR - https://doi.org/10.1155/2016/4701890 DO - 10.1155/2016/4701890 JF - Evidence-Based Complementary and Alternative Medicine PB - Hindawi Publishing Corporation KW - ER -