TY -的A2将Debprasad AU -赛义德,艾哈迈德阿米尔Radwan PY - 2012 DA - 2012/09/06 TI - Ferulsinaic酸调节SOD、谷胱甘肽和抗氧化酶在糖尿病肾脏SP - 580104六世- 2012 AB - Ferulsinaic酸(FA)的功效调节抗氧化酶,减少氧化应激induced-diabetic肾病(DN)进行了研究。老鼠的饮食富含蔗糖(50%,wt / wt),猪油(30%,wt / wt)、胆固醇(2.5%,wt / wt) 8周诱导胰岛素抵抗。后一个DN模式是由链脲霉素诱导;5、50和500毫克/公斤的足总被口服胃内的管理插管为12周。葡萄糖在FA-treated糖尿病大鼠,肾/体重比,肌酐,包子,albuminurea,肌酐清除率显著下降而非治疗糖尿病大鼠。糖尿病大鼠SOD显示减少活动,谷胱甘肽;丙二醛和血清中il - 6的浓度增加,肾脏,并增加水平的8-hydroxy-2′脱氧鸟苷在尿和肾皮质。FA-treatment恢复以剂量依赖性的方式改变参数。超形态学异常在糖尿病大鼠的肾脏被足总治疗明显改善。此外,足总酸被发现减弱慢性炎症引起的卡拉胶和右旋糖酐老鼠。 We conclude that FA confers protection against injuries in the kidneys of diabetic rats by increasing activities of antioxidant enzymes and inhibiting accumulation of oxidized DNA in the kidney, suggesting a potential drug for the prevention and therapy of DN. SN - 1741-427X UR - https://doi.org/10.1155/2012/580104 DO - 10.1155/2012/580104 JF - Evidence-Based Complementary and Alternative Medicine PB - Hindawi Publishing Corporation KW - ER -