Ty-Jour A2 - Rybakowski，Janusz K. Au - Hosseinzadeh，Ali Au - Boroujeni，Shakiba Nasiri Au - Saghaei，Elham Au - Loriooini，Zahra Au - Dehkordi，Saeid Habibian Au - Balali-dehkordi，Shima Au - Rahimi-Madiseh，Mohammad Au - Amini-Khoei，Hossein Py - 2021Da - 2021/04/22 Ti - 腺苷酰基环酶（AC）介导仔细动物的抗抑郁药物效果在母体分离应力SP的小鼠模型 - 5586119 VL - 2021 AB - 该Adenylyl Cyclase（AC）途径参与抑郁症的病理生理学。有必要找到具有高药用性能和低副作用的新抗抑郁药。因此，考虑到AC的可能作用，本研究旨在确定对象汀对小鼠母体分离（MS）模型的抗抑郁效果。NMRI雄性小鼠分为11组。用盐水处理对照组，并用盐水，对象四（5-HT3受体拮抗剂）处理MS基团，剂量为1,3和5mg / kg;在5,10和25mg / kg的剂量下进行泡菜（AC的活化剂）;一种具有逆孢子剂量的FORSKOLIN的底部射精剂量;和有效剂量的对象蛋白加上有效剂量的NB001（3mg / kg）（AC抑制剂）。 After treatment, animals were subjected to behavioral tests including the forced swimming test (FST), splash test, and open field test (OFT). We showed that MS caused depressive-like behaviors determined as an increase in the immobility time in the forced swimming test (FST) and decreased grooming time in the splash test. Our results showed that administration of tropisetron, as well as forskolin, mitigated the depressive-like behaviors in MS mice. We found that coadministration of a subeffective dose of tropisetron plus a subeffective dose of forskolin potentiated the antidepressant-like effect of tropisetron. However, coadministration of an effective dose of NB001 with an effective dose of tropisetron did not significantly affect the antidepressant-like effect of tropisetron. We concluded that the antidepressant-like effects of tropisetron on MS mice are partially mediated through the adenylyl cyclase pathway. SN - 2090-1321 UR - https://doi.org/10.1155/2021/5586119 DO - 10.1155/2021/5586119 JF - Depression Research and Treatment PB - Hindawi KW - ER -