TY -的A2 -谢,仲秋节非盟-朱,延安盟——张Cangang盟——赵,东屿AU -李,“非盟-赵,哲盟——姚明,Shukun盟——赵,冬艳PY - 2021 DA - 2021/11/05 TI - BDNF作为预后因子与肿瘤浸润在胰腺癌Th2细胞SP - 7842035六世- 2021 AB -胰腺腺癌(PAAD)是一个全球极其致命的疾病。脑源性神经营养因子(BDNF)是一个关键的成员生成多肽在多个癌症总科,起着重要的作用。然而,BDNF表达之间的协会,肿瘤免疫,PAAD预后仍不清楚。BDNF表达和对病人的预后的影响进行了探讨基于癌症基因组图谱,癌症细胞系的百科全书,Genotype-Tissue表达式,kaplan meier绘图仪。基因集富集分析理解脑源性神经营养因子的生物学作用。脑源性神经营养因子的作用在肿瘤浸润免疫细胞决心使用免疫评估资源数据库和single-sample基因集富集分析和伊势亚算法。相关脑源性神经营养因子和趋化因子,趋化因子受体,化疗效果,基于RStudio免疫分析了检查站。BDNF表达显著高于PAAD配对正常组织相比,和高BDNF表达与预后不利。富集分析显示,脑源性神经营养因子显著富集在PAAD致癌的主要途径。BDNF表达呈正相关,免疫渗透,特别是Th2细胞。 Moreover, BDNF expression was positively correlated with Th2 cell-related chemokine/chemokine receptors, indicating that BDNF might modulate the migration of Th2 cells in PAAD. We also found that BDNF expression was correlated with high chemotherapeutics sensitivity and highly expressed immune checkpoints, making it a valuable biomarker in predicting the therapeutic benefits for chemotherapy and immunotherapy in cancer patients. In summary, BDNF might affect patient prognosis by interacting with tumor-infiltrating Th2 cells, thus serving as a potential prognostic biomarker in PAAD. SN - 0278-0240 UR - https://doi.org/10.1155/2021/7842035 DO - 10.1155/2021/7842035 JF - Disease Markers PB - Hindawi KW - ER -