TY - JOUR A2 - Theocharis, Stamatios AU - Wu, Jiangdong AU - Lu, Lijun AU - Zhang, Le AU - Ding, Yulei AU - Wu, Fang AU - Zuo, Weize AU - Zhang, Wanjiang PY - 2015 DA - 2015/12/20 TI - Single Nucleotide Polymorphisms inP2X7Gene Are Associated with Serum Immunoglobulin G Responses toMycobacterium tuberculosisin Tuberculosis Patients SP - 671272 VL - 2015 AB - Objective. Our study investigated the association between single nucleotide polymorphisms (SNPs) in P2X7 gene and serum immunoglobulin G (IgG) responses to mycobacterium tuberculosis (MTB) in TB patients. Methods. A total of 103 TB patients were enrolled as case group and 87 healthy individuals at same geographical region as control group. The SNP detection of 1513A>C and -762T>C was performed using PCR-RFLP, and the levels of serum IgG responses to MTB in all subjects were determined. Results. AC and CC of 1513A>C and TC and CC of -762T>C had higher frequencies in case group than in control group. TB patients carrying TC and CC of -762T>C had higher positive rate of IgG responses to MTB than those carrying TT. Additionally, patients carrying TC and CC of -762T>C had more MTB in sputum than those carrying TT. Conclusion. P2X7 SNPs, 1513A>C and -762T>C, may be associated with the susceptibility to tuberculosis, and -762T>C SNP may contribute to the development of MTB. The mutant genotype of -762T>C (TC and CC) may lower human capability of phagocytosis to MTB, leading to an increased morbidity of TB. SN - 0278-0240 UR - https://doi.org/10.1155/2015/671272 DO - 10.1155/2015/671272 JF - Disease Markers PB - Hindawi Publishing Corporation KW - ER -