TY -的A2 Harangi欧盟盟——Numakura滨盟——Kagaya Hideaki盟,山本Ryohei盟——Komine Naoki盟——斋藤Mitsuru盟——Hiroshi Tsuruta盟——Akihama Susumu盟——井上,Takamitsu盟——成田Shintaro AU -土屋,最初盟——Habuchi Tomonori盟——Niioka Takenori盟,三浦Masatomo盟,佐藤晴茂PY - 2015 DA - 2015/04/06 TI -表征与血脂异常相关的临床和遗传风险因子在肾移植后SP - 179434六世- 2015 AB -我们决定血脂异常的患病率在日本的肾移植受者和调查临床和遗传特性有关联the disease. In total, 126 patients that received renal allograft transplants between February 2002 and August 2011 were studied, of which 44 recipients (34.9%) were diagnosed with dyslipidemia at 1 year after transplantation. Three clinical factors were associated with a risk of having dyslipidemia: a higher prevalence of disease observed among female than male patients P ＝ 0.021 用高霉酚酸酯处理 P ＝ 0.012 和强的松 P ＝ ０．０２３ 在移植后28天按体重给药。我们分析了血脂异常与38个可能的疾病相关基因中的60个先前描述的遗传多态性之间的遗传关联。糖皮质激素受体患者出现血脂异常的频率明显更高( NR3C1） Bcl1G等位基因比CC基因型的人多 P ＝ ０．００１ ．多变量分析显示 NR3C1 Bcl1G等位基因是血脂异常患病率的显著危险因素(优势比= 4.6;95%可信区间= 1.8 ~ 12.2)。这些发现可能有助于预测患者发生血脂异常的风险。SN - 0278-0240 UR - https://doi.org/10.1155/2015/179434 DO - 10.1155/2015/179434 JF - Disease Markers PB - Hindawi Publishing Corporation KW - ER -