TY -的A2 -罗西,安德里亚·p . AU -阮Ngoc-Thanh-Van AU - Tran Diep老爷盟——勒,范教授非盟- Van黄平君Sy盟——阮Hoai-An AU -洲,阿花Ngoc PY - 2021 DA - 2021/01/15 TI -临床表型和与年龄相关的差异表现,治疗,和心脏衰竭的结果保存射血分数:越南多中心研究SP - 4587678六世- 2021 AB - 背景。心力衰竭与保存射血分数(HFpEF)是一个日益增长的医疗问题,异构表示和以证据为基础的治疗。而东南亚报道亚洲人口的死亡率和患病率最高,对越南人口,包括病人特点、处方模式和死亡率。 方法。我们进行了一项观察性研究477例诊断为HFpEF从七医院从2019年1月至2019年12月在越南南部。 结果。平均年龄是67.6(40.9% < 65年)。62.3%是女性。82.4%的人在5年内诊断。呼吸困难、交通拥堵和低灌注入院时被发现在63.9%,48.8%,和4.6%的病人,分别。平均射血分数为63%。心脏瓣膜病(VHD)心力衰竭的主要原因(35.9%)。78.6%的人至少有两个并存病,主要是高血压(68.6%)。住院患者的30.6%,中值保持为7.0(4.0 - -10.0)35例,死亡率为4.8%。老年人(≥65岁)更容易被女性(或= 1.52); had multimorbid conditions (OR = 3.14), including hypertension (OR = 4.28), diabetes (OR = 1.73), coronary artery disease (CAD) (OR = 2.50), dyslipidemia (OR = 1.94), and chronic kidney disease (OR = 2.44); and were more frequently prescribed statin (OR = 3.15). Younger individuals (<65 years) were associated with higher mineralocorticoid antagonist uptake (OR = 0.52) and VHD (OR = 0,40). Prescription rate for renin-angiotensin-aldosterone system inhibitor, beta blocker, mineralocorticoid antagonist, and loop diuretic was 72.5%, 59.1%, 43.0%, and 60.6%, respectively. Four phenotypes were identified, including the lean/elderly/multimorbid; congestive/metabolic; CAD-induced; and younger/atrial fibrillation (AF)/VHD. The novel phenotype “younger/AF/VHD” exhibited high symptom burden and poor functional capacity despite being the youngest and least multimorbid. The “lean/elderly/multimorbid” phenotype demonstrated the highest symptom severity and inhospital mortality. 结论。我们的研究凸显了年轻,与高疾病负担以女性为主。四个使用新方法确定表型提供当代和务实的见解phenotype-guided方法,专门针对越南人口。SN - 2090 - 8016 UR - https://doi.org/10.1155/2021/4587678 - 10.1155 / 2021/4587678摩根富林明心脏病学研究和实践PB - Hindawi KW - ER