TY - JOUR A2 - Rocha, Manoel Otavio。C AU - Cai, Yufeng AU - Zhang, Xueyan AU - Shen, Jie AU - Jiang, Boyue AU - Hu, Dehua AU - Zhao, Mingyi PY - 2020 DA - 2020/06/15 TI -肝素结合蛋白:SP - 9575373 VL - 2020 AB -心血管疾病是严重影响生活质量的一组重要疾病。因此，他们的治疗值得进一步研究。肝素结合蛋白(HBP)是一种来源于中性粒细胞的粒细胞蛋白。当感染发生时，中性粒细胞释放HBP，可导致血液中HBP水平升高。因此，HBP家族成员被认为是感染的重要指标。然而，HBP与心血管疾病之间可能存在的关系尚缺乏基础证据。利用生物信息学方法，我们研究了HBP网络在正常心脏和心血管疾病患者心脏中的作用。首先，我们使用Open Targets数据库获取与动脉粥样硬化、心肌炎、心肌梗死和心肌缺血相关的hbp编码mrna列表。 Then, we constructed an HBP gene interaction network map using STRING. Clustering coefficients were calculated using Cytoscape, and MCODE was used for subnet analysis. Finally, the proposed interstitial network of HBPs was established and analyzed by Metascape enrichment analysis of the relevant signaling pathways. The aggregation coefficient of the HBP interaction network was higher among hearts with the four cardiovascular diseases, atherosclerosis (0.496), myocarditis (0.631), myocardial infarction (0.532), and myocardial ischemia (0.551), than in normal hearts. Metascape analysis showed that “NABA_MATRISOME_ASSOCIATED” was a typical pathway with the highest p 在所有四种疾病中与上皮化相关的值此外，还发现了大量可能对这些疾病的治疗具有重要意义的HBPs。因此，HBPs在心血管疾病中确实具有高度的特应性连接网络，特定的HBPs或信号通路可能被用作开发心血管疾病新疗法的靶点。SN - 2090-8016 UR - https://doi.org/10.1155/2020/9575373 DO - 10.1155/2020/9575373 JF - Cardiology Research and Practice PB - Hindawi KW - ER -