TY - JOUR A2 - Dell 'Osso, Liliana AU - Patel, Kamal AU - Lilly, Brandon AU - Ajayi, Oluwadamilare AU - Melvin,凯利PY - 2018 DA - 2018/07/15 TI -的安定药恶性综合征的严重患者智力障碍成功重新抗精神病治疗喹硫平SP - 7045106六世- 2018 AB -安定药恶性综合征(NMS)是一种罕见的疾病在临床上表现为肌肉僵硬,高热,自主神经不稳定,急性精神状态改变。NMS最常与第一代高效抗精神病药物的使用有关;不过,其他的神经安定药也有牵连。NMS可能是致命的,估计死亡率高达20%。患有某些严重并发症(包括肾功能衰竭)的患者的死亡率高达50%,这强调了早期识别和治疗的必要性。我们在此报告一例54岁男性患者,最初表现为可疑的败血症症状,但最终发展为与NMS一致的临床表现。我们描述了导致症状缓解的诊断和治疗过程。然后我们讨论重新引入非典型抗精神病药物奎硫平的决定。 This case illustrates the importance of early recognition of the signs and symptoms of NMS and the need to initiate treatment promptly in order to prevent complications, including death. This case also highlights the decision to resume antipsychotic pharmacotherapy after adequate resolution of NMS, demonstrating that it can be done so safely if started at low doses coupled with intensive monitoring of the patient. SN - 2090-682X UR - https://doi.org/10.1155/2018/7045106 DO - 10.1155/2018/7045106 JF - Case Reports in Psychiatry PB - Hindawi KW - ER -