TY - JOUR A2 - Motegi, S.-I. A2 - Strecker, T. A2 - Picken, M. M. AU - Puppa, Giacomo AU - Molaro, Mariella PY - 2012 DA - 2012/11/19 TI - Dome-Type: A Distinctive Variant of Colonic Adenocarcinoma SP - 284064 VL - 2012 AB - Introduction. Ten cases of dome-type adenocarcinoma of the colon have been reported so far. Most of them were presented as early lesions, with endoscopic and microscopic distinguishing features. Methods and Results. A raised plaque was removed from the right colon during colonoscopy in a 56-year-old man. Histopathological examination showed a cancerized adenoma invading the submucosa with several typical features of dome-type adenocarcinoma, in particular the associated prominent lymphoid tissue. Immunohistochemistry showed retention of the mismatch repair proteins MLH-1, MSH-2, MLH-6, and PMS-2. Conclusion. We report an additional case of dome-type adenocarcinoma of the colon as an early, low-risk, and microsatellite stable tumor, indicating that this particular histotype may deserve specific consideration for both classification and management. SN - 2090-6781 UR - https://doi.org/10.1155/2012/284064 DO - 10.1155/2012/284064 JF - Case Reports in Pathology PB - Hindawi Publishing Corporation KW - ER -