TY - JOUR A2 - 阿里夫，萨拉赫AU - 书信集，赖莎AU - 这样做，Tiffanie AU - Vankina，Ritika AU - 吴，丹尼尔AU - 叶，詹姆斯AU - 弗莱施曼，迈克尔W. AU - 李，珍妮弗M. PY - 2020DA - 2020/03/26 TI - Immune Thrombocytopenic Purpura (ITP) as an Uncommon Extraintestinal Complication of Crohn’s Disease: Case Vignette and Systematic Literature Review SP - 4785759 VL - 2020 AB - While the association of immune thrombocytopenic purpura (ITP) and inflammatory bowel disease (IBD) has been described in a few case reports, management of ITP as an extraintestinal manifestation of Crohn’s disease (CD) is less studied. There are approximately a dozen cases describing the management of patients dually diagnosed with CD/ITP. Previous reports postulated that the mechanism of ITP in CD was through the presence of circulating immune complexes in the serum and antigenic mimicry due to increased mucosal permeability in active colitis, versus increased mucosal production of TH1-type proinflammatory cytokines during CD flares, which may account for remission of ITP with surgery for CD. We present a case of a 27-year-old man who presented with medically refractory CD and ITP who responded to surgical management with colectomy and splenectomy, along with a systematic review of the literature. These cases suggest that colectomy should be considered in the treatment of medically refractory ITP among patients with concomitant CD. SN - 2090-6560 UR - https://doi.org/10.1155/2020/4785759 DO - 10.1155/2020/4785759 JF - Case Reports in Hematology PB - Hindawi KW - ER -