TY -的A2 -臼井仪人,武盟-戈登,Michael s . AU -戈登,穆雷b . PY - 2016 DA - 2016/08/30 TI -神秘的朗格汉斯细胞组织细胞增生症与乳头状甲状腺癌,增厚垂体和尿崩症SP - 5191903六世- 2016 AB -增厚茎的病因包括炎症、肿瘤、特发性起源,底层的诊断可能保持神秘。我们报告一个病人增厚垂体(TPS)和乳头状甲状腺癌(PTC)的诊断仍然模糊,直到皮肤病变出现。postthyroidectomy病人面对PTC,地位,和我^131年治疗。PTC分子测试显示BRAF变异(V600E, GTC >呕吐)。她有5年的历史多尿、烦渴。隔夜脱水研究证实了尿崩症(DI)。MRI显示TPS脑垂体后叶损失的亮点。评估显示hypogonadotropic性腺机能减退,igf - 1低。胸部x光片和ACE水平是正常的。射线照片来评估extrapituitary网站的朗格汉斯细胞组织细胞增生症(LCH)稀松平常的。生殖细胞瘤研究负面:正常血清和CSF beta-hCG,甲胎蛋白和CEA。三年后,病人出现会阴部的唇随后腹股沟区皮肤损伤,活检显示华尔街日报。 Reanalysis of thyroid pathology was consistent with concurrent LCH, PTC, and Hashimoto’s thyroiditis within the thyroid. This case illustrates that one must be vigilant for extrapituitary manifestations of systemic diseases to diagnose the etiology of TPS. An activating mutation of the protooncogene BRAF is a potential unifying etiology of both PTC and LCH. SN - 2090-6501 UR - https://doi.org/10.1155/2016/5191903 DO - 10.1155/2016/5191903 JF - Case Reports in Endocrinology PB - Hindawi Publishing Corporation KW - ER -