TY - JOUR A2 - 韦克斯曼，肯尼斯S. AU - 考尔，Jaspinder AU - 库马尔，迪利普AU - Alfishawy，穆斯塔法AU - 洛佩斯，里卡多AU - Sachmechi，伊萨克PY - 2016 DA - 2016年9月18日TI - 帕潘立酮诱导随之而来2587963 VL - - 2016 AB - 抗利尿激素，神经阻滞剂恶性综合征，和横纹肌溶解SP的帕潘立酮综合征，利培酮的活性代谢物，是一种新的非典型抗精神病药物。抗利尿激素（SIADH），抗精神病药物恶性症候群（NMS），和横纹肌溶解综合征是精神药物的罕见副作用 。We report a case of 35-year-old male with schizoaffective disorder who was admitted for acute-on-chronic exacerbation of his psychotic disorder for which intramuscular paliperidone 234 mg injection was given. Two days later, the patient developed hyponatremic seizures secondary to SIADH which was treated with hypertonic saline. On the third day, he developed high grade fever and severe muscle rigidity with raised creatine phosphokinase (CPK) and liver enzymes levels. He was treated with dantrolene 100 mg, bromocriptine 2.5 mg, and lorazepam 2 mg. Our patient required management of the three rare conditions following treatment with paliperidone. This case highlights the need for health care providers to be aware of the rare, potentially life threatening but preventable hyponatremia, NMS, and rhabdomyolysis as a possible adverse effect of paliperidone. SN - 2090-6420 UR - https://doi.org/10.1155/2016/2587963 DO - 10.1155/2016/2587963 JF - Case Reports in Critical Care PB - Hindawi Publishing Corporation KW - ER -