TY - JOUR A2 - Huang, Tao AU - Song, Xiaolong AU - Kong, Junhong AU - Song, Jun AU - Pan, Renyou AU - Wang, Lei PY - 2021 DA - 2021/09/06 TI - Angelica sinensis Polysaccharide Alleviates Myocardial Fibrosis and Oxidative Stress in the Heart of Hypertensive Rats SP - 6710006 VL - 2021 AB - This research is aimed at studying the effect of Angelica sinensis polysaccharide (ASP) extracted from the Lixinshui prescription on cardiac disease induced by hypertension in rats. Rat models of cardiovascular disease were established, and the associated factors were measured. The data showed that ASP treatment increased the ejection fraction and short axis shortening rate, while decreasing the LV end-diastolic diameter, LV end-systolic diameter, LV end-diastolic volume, and LV end-systolic volume in HHD rats. ASP downregulated the expression level of TGF- β1, alpha-smooth muscle actin ( α-SMA), collagen I, fibronectin, vimentin, Bax, cleaved caspase-9, and cleaved caspase-3 and upregulated the expression level of Bcl-2 in LV of HHD rats. Meanwhile, ASP increased the activity of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) and decreased the level of malondialdehyde (MDA), tissue endogenous hydrogen peroxide (H₂O₂), and reactive oxygen species (ROS). Our findings indicated that ASP could prevent hypertensive heart disease by inhibiting myocardial fibrosis, suppressing the myocardial apoptosis, and alleviating oxidative stress. SN - 1748-670X UR - https://doi.org/10.1155/2021/6710006 DO - 10.1155/2021/6710006 JF - Computational and Mathematical Methods in Medicine PB - Hindawi KW - ER -