TY -的A2 - Lu Chuan盟,曾庆红,李盟——陈,年兽盟——廖Junlin盟——沈,徐盟歌,盛华AU -王,冯PY - 2021 DA - 2021/10/04 TI -代谢分析与系统性红斑狼疮相关的潜在关键基因利用液相色谱-光谱法SP - 5799348六世- 2021 AB -生物机制系统性红斑狼疮(SLE)的发病机制仍不清楚。在这项研究中,我们发现21蛋白质调节和38个蛋白表达下调的系统性红斑狼疮相对于正常的蛋白质代谢在我们的样本使用液体色谱-光谱法。PPI网络分析,我们确定了9系统性红斑狼疮的关键蛋白质,包括AHSG、VWF、IGF1, ORM2, ORM1, SERPINA1, IGF2, IGFBP3、地蜡。此外,我们发现4569年系统性红斑狼疮血清差异表达代谢物,包括1145年减少代谢物和3424年诱导代谢产物。生物信息学分析表明,蛋白质变化在系统性红斑狼疮与调制多种免疫途径,TP53信号,AMPK信号。此外,我们发现改变代谢物与缬氨酸,亮氨酸,异亮氨酸生物合成;一个碳池叶酸;酪氨酸代谢;精氨酸和脯氨酸代谢;甘氨酸、丝氨酸和苏氨酸代谢; limonene and pinene degradation; tryptophan metabolism; caffeine metabolism; vitamin B6 metabolism. We also constructed differently expressed protein-metabolite network to reveal the interaction among differently expressed proteins and metabolites in SLE. A total of 481 proteins and 327 metabolites were included in this network. Although the role of altered metabolites and proteins in the diagnosis and therapy of SLE needs to be further investigated, the present study may provide new insights into the role of metabolites in SLE. SN - 1748-670X UR - https://doi.org/10.1155/2021/5799348 DO - 10.1155/2021/5799348 JF - Computational and Mathematical Methods in Medicine PB - Hindawi KW - ER -