TY -的A2 -黄,道盟——刘道盟方,Yuejun PY - 2021 DA - 2021/06/07 TI -研究GABRD表达式和预后价值的结肠癌和Coexpressed基因网络建设基于数据挖掘SP - 5544182六世- 2021 AB -结肠癌的前五名是世界上发病率最高的癌症。为了更好地理解结肠癌的发病和进展,仍有必要在癌组织基因表达的异常进行调查。在这项研究中,Oncomine数据库是用于表达分析,发现γ-氨基丁酸A型受体的表达水平δ(GABRD)基因调节亚基在结肠癌组织与正常组织。UALCAN用于分析GABRD的表达在不同组的年龄、性别、肿瘤分期、N阶段,组织学亚型。然后,这是还发现,在每个子群GABRD的表达结肠癌组织都是高的价格相比正常组织。LinkedOmics被用来屏幕GABRD表达相关的差异表达基因的结肠癌。去注释和KEGG通路富集分析发现可能与乳腺癌相关基因,人类乳头状瘤病毒感染,切口信号通路和其他途径。此后,GSEA执行获得GABRD-related激酶,microrna、转录因子和基因相互作用网络构造。发现GABRD可能参与细胞周期调控。最后,网站像GEPIA用来探测的预测能力GABRD结肠癌患者的预后。 Kaplan-Meier analysis suggested that the upregulation of GABRD expression was related to the poor prognosis of patients with colon cancer. Overall, in this study, the potential role and prognostic ability of GABRD in colon cancer were explored through data mining, which can be a clue for further research on GABRD. SN - 1748-670X UR - https://doi.org/10.1155/2021/5544182 DO - 10.1155/2021/5544182 JF - Computational and Mathematical Methods in Medicine PB - Hindawi KW - ER -