TY -的A2 -黄,道盟——张Conghui AU -李,杰盟-杨,局域网盟——徐Fengxia盟——她,汇源盟——刘,星辉PY - 2021 DA - 2021/03/31 TI -转录组分类揭示分子子组患者的乙型肝炎病毒SP - 5543747六世- 2021 AB -专门乙型肝炎病毒(HBV)感染肝细胞,这会导致进行性肝纤维化，并显著增加患肝癌的风险。多项研究表明，宿主遗传、病毒学和免疫学因素可能影响HBV感染。然而，HBV感染的潜在机制尚不清楚。本研究通过对124例HBV患者(GEO accession: GSE84044)的基因表达数据分析，确定了HBV感染患者的分子亚群，包括C1、C2、C3组。比较三组患者的年龄、纤维、化学和炎症程度以及基因表达差异。此外，利用93个肝脏特异性基因计算肝脏指数。深入分析HBV患者不同分子亚群肝脏特异性基因表达情况，并与纤维化、炎症水平进行比较。结果显示，C2组年龄最小，C3组纤维化和炎症程度最高。富集分析显示，代谢相关通路主要在C1和C2组表达，肿瘤炎症相关通路和蛋白多糖在C1和C3组高表达。 The liver index was higher in the C2 group than in the C1 and C3 groups, and it was the lowest in the C3 group. Macrophage M1/M2 and neutrophils were significantly different in the three groups. M1 was mainly abundant in the C3 group, and M2 and neutrophils were mainly abundant in the C2 group. This study provides novel information to understand the mechanisms of HBV infection in chronic hepatitis B (CHB) patients. SN - 1748-670X UR - https://doi.org/10.1155/2021/5543747 DO - 10.1155/2021/5543747 JF - Computational and Mathematical Methods in Medicine PB - Hindawi KW - ER -