ty -jour a2 -liao,chung -min au -lambura,Aristide G.Au -Mwanga,Mwanga,Gasper G. Au -Luboobi -Luboobi,Livingstone Au -Kuznetsov,Dmitry PY -2020 DA -2020/2020/11/18 TI-建模效果最佳控制策略下结核分枝杆菌的传播动力学的蠕虫感染SP -8869377 VL -2020 AB-一种确定性的数学模型,用于呈现异常和控制结核病的传播和控制,以检查呈现用于头盔的影响,以检查头盔对结核病的影响。控制策略。建立了平衡点,并计算有效的繁殖数。每当有效的繁殖数小于单位时,无病平衡点被证实在渐近稳定。对有效繁殖数的分析表明,蠕虫病例的增加增加了结核病病例,这表明对蠕虫感染的控制对控制结核动力学有积极影响。使用中心歧管定理研究了分叉的可能性。进行灵敏度分析以确定每个参数对两种疾病扩散的影响。该模型被扩展以结合控制措施,并应用了Pontryagin的最大原理来得出最佳控制的必要条件。最佳控制问题是通过迭代方案来解决的,通过考虑为MTB的婴儿进行疫苗接种,主动结核病患者的治疗,常规抗固定药物的大众药物给药以及卫生控制策略。 The results show that a combination of educational campaign, treatment of individuals with active tuberculosis, mass drug administration, and sanitation is the most effective strategy to control helminth-Mtb coinfection. Thus, to effectively control the helminth-Mtb coinfection, we suggest to public health stakeholders to apply intervention strategies that are aimed at controlling helminth infection and the combination of vaccination of infants and treatment of individuals with active tuberculosis. SN - 1748-670X UR - https://doi.org/10.1155/2020/8869377 DO - 10.1155/2020/8869377 JF - Computational and Mathematical Methods in Medicine PB - Hindawi KW - ER -