TY - Jour A2 - Huang，Tao Au - Liu，Jiazhe Au - Li，鸿昌奥维，蔡芳奥·叮，朱斌 - 陆，京峰互惠泛，高峰奥 - 毛，高峰互惠，Anwei PY - 2020 DA - 2020 /10/20 Ti - Circfat1（E2）通过MiRNA-873 / Zeb1轴SP-1459368 VL-2020 AB - 圆形RNA（Circrnas）促进乳头状甲状腺癌的增殖，迁移和侵袭在发生和中发挥极为重要的监管作用在乳头状甲状腺癌（PTC）中的各种恶性肿瘤的发展。Quotfat1（E2）是一种来自FAT1基因的外显子2的新类型的Circrna，其分布在PTC细胞的细胞质和核中。然而，到目前为止，Circfat1（E2）在PTC中的作用尚不清楚。在本研究中，发现QuItfat1（E2）在PTC细胞系和组织中高度表达。Circfat1（E2）敲低抑制PTC细胞生长，迁移和侵袭。此外，昼夜昼夜Q（E2）充当潜在的microRNA（miRNA）的海绵，以调节癌症进展。发现潜在的miRNA靶标是MiR-873，其在PTC中的Quotfat1（E2）靶向。稍后进行的双荧光素酶测定结果证实确实存在昼夜呋喃（E2）和miR-873之间的直接相互作用。 This study also confirmed that circFAT1(e2) inhibited the miR-873 expression and thus promoted the ZEB1 expression, thus affecting the proliferation, metastasis, and invasion of PTC cells. In conclusion, the results of this study indicated that circFAT1(e2) played a carcinogenic role by targeting the miR-873/ZEB1 axis to promote PTC invasion and metastasis, which might become a potential novel target for therapy of PTC. SN - 1748-670X UR - https://doi.org/10.1155/2020/1459368 DO - 10.1155/2020/1459368 JF - Computational and Mathematical Methods in Medicine PB - Hindawi KW - ER -