TY -的A2 -冯,于非盟- Xi,金乡盟——Talaat Mohamed AU - Tanbour Hesham盟——Talaat Khaled PY - 2018 DA - 2018/09/25 TI -气流和颗粒沉积在腺泡的模型与牙槽间的间隔墙和不同肺泡数量SP - 3649391六世- 2018 AB -独特的功能存在于腺泡的单位等多个肺泡,牙槽间的间隔墙,和科恩的毛孔。然而,这些特性对气流和颗粒沉积的影响仍不量化由于其结构的复杂性。本研究旨在数值研究粒子在腺泡的动力学模型与牙槽间的间隔墙和科恩的毛孔。简化4-alveoli模型定义良好的几何图形和生理上现实45-alveoli模型开发。经拉格朗日跟踪模型被用来模拟粒子轨迹的腺泡的模型有节奏地膨胀和收缩运动。两种时空在腺泡的剂量学模型进行了分析。结果表明,间接通风存在在肺泡中由于压力不平衡。牙槽间的间隔大小的孔径显著改变了空间沉积模式,尽管它有一个微不足道的总沉积速率的影响。令人惊讶的是,45-alveoli模型中的沉积速率低于4-alveoli模型,表明强粒子分散在更复杂的模型。重力方向角减少影响腺泡的沉积率与越来越多的肺泡保留在模型中; such an effect is nearly negligible in the 45-alveoli model. Breath-holding increased particle deposition in the acinar region, which was most significant in the alveoli proximal to the duct. Increasing inhalation depth only slightly increases the fraction of deposited particles over particles entering the alveolar model but has a large influence on dispensing particles to the peripheral alveoli. Results of this study indicate that an empirical correlation for acinar deposition can be developed based on alveolar models with reduced complexity; however, what level of geometry complexity would be sufficient is yet to be determined. SN - 1748-670X UR - https://doi.org/10.1155/2018/3649391 DO - 10.1155/2018/3649391 JF - Computational and Mathematical Methods in Medicine PB - Hindawi KW - ER -