TY - JOUR A2 - Herranz，费尔南多AU - 拉米雷斯 - 纳瓦，赫拉尔AU - 桑托斯 - 奎瓦斯，克拉拉AU - 铁 - 弗洛雷斯，Guillermina AU - 奥坎波 - 加西亚，布兰卡AU - Chairez，艾萨克AU - 戈麦斯Argumosa，埃德加AU -Abundiz洛佩斯，卢塞罗AU - 加西亚 - 佩雷斯，旧金山O. PY - 2020 DA - 2020年5月7日TI - 放射性标记纳米金的前哨淋巴结检测的混合（2D / 3D）放射量测定与乳腺癌患者的SP - 2728134VL - 2020 AB - 此前，我们报道了准备和临床前研究^99米Tc-标记的金纳米颗粒甘露糖（^99米TC-金纳米粒子甘露糖），与潜在的前哨淋巴结（SLN）检测用核医学程序。本研究旨在评估生物动力学和混合（2D / 3D）剂量的^99米TC-的AuNP甘露糖在五名患者患有乳腺癌的前哨淋巴结检测协议下。Anterior and posterior whole-body planar images (2D, at 0.5, 2, 6, and 24 h) and single-photon emission computed tomography (3D at 6.5 h)/computed tomography (SPECT/CT) images were acquired after^99米Tc-AuNP-mannose administration (37 MBq). Through a hybrid quantification method, activity in tissues of interest at the different acquisition times was determined and integrated over time to obtain the total nuclear transformations ( ñ），以及平均停留时间，每个组织。 ñ值和OLINDA代码被用于估计所述内部辐射吸收剂量。结果表明，^99米Tc-AuNP-mannose successfully accumulates and remains up to 24 h in the sentinel lymph node without detectable migration to other lymph nodes and no side effects on patients. Negligible absorption of the radiolabeled nanoparticles into the circulatory system was observed, from which the radio-nanosystem is rapidly eliminated by kidneys. Hybrid (2D/3D) dosimetry evaluations showed equivalent doses to SLN, breast, and kidneys of 172.34, 5.32, and 0.08 mSv/37 MBq, respectively, with an effective dose of 2.05 Ë − 03 mSv/MBq. The mean effective residence time in SLN was 0.92 h. This preliminary study indicates that the use of^99米Tc-AuNP-mannose for successful SLN detection in patients is safe, producing an effective dose at the level recommended for diagnostic studies (<10 mSv). SN - 1555-4309 UR - https://doi.org/10.1155/2020/2728134 DO - 10.1155/2020/2728134 JF - Contrast Media & Molecular Imaging PB - Hindawi KW - ER -