TY - JOUR A2 - Šefc, Luděk AU - Fiordelisi, M. F. AU - Auletta, L. AU - Meomartino, L. AU - Basso, L. AU - Fatone, G. AU - Salvatore, M. AU - Mancini, M. AU - Greco, A. PY - 2019 DA - 2019/09/22 TI - Preclinical Molecular Imaging for Precision Medicine in Breast Cancer Mouse Models SP - 8946729 VL - 2019 AB - Precision and personalized medicine is gaining importance in modern clinical medicine, as it aims to improve diagnostic precision and to reduce consequent therapeutic failures. In this regard, prior to use in human trials, animal models can help evaluate novel imaging approaches and therapeutic strategies and can help discover new biomarkers. Breast cancer is the most common malignancy in women worldwide, accounting for 25% of cases of all cancers and is responsible for approximately 500,000 deaths per year. Thus, it is important to identify accurate biomarkers for precise stratification of affected patients and for early detection of responsiveness to the selected therapeutic protocol. This review aims to summarize the latest advancements in preclinical molecular imaging in breast cancer mouse models. Positron emission tomography (PET) imaging remains one of the most common preclinical techniques used to evaluate biomarker expression 体内，而磁共振成像（MRI），特别是扩散加权（DW）的序列，已被证明是能够从非应答者区分应答者对于传统和创新的化疗和免疫疗法具有高灵敏度和在非侵入性的方式。定制疗法的能力是可取的，因为这将使早期检测的疾病和治疗对个体患者轮廓剪裁。动物模型在努力理解的分子机制和肿瘤疾病的模式仍然不可替代。SN - 1555-4309 UR - https://doi.org/10.1155/2019/8946729 DO - 10.1155 /八百九十四万六千七百二十九分之二千○一十九JF - 对比度媒体及分子成像PB - Hindawi出版KW - ER -