TY -的A2 Solimando安东尼奥乔凡尼非盟-罗,越盟——林Junhao盟——张Jiakang盟歌,商谈AU -郑Dayong AU - Chen Fengsheng盟,壮族Xuefen AU -李,爱民盟——刘,辉PY - 2021 DA - 2021/09/14 TI - LncRNA SNHG17导致增殖,迁移,肝细胞癌的预后不良SP - 9990338六世- 2021 AB -长非编码rna (lncRNAs)大幅报道近年来调节肿瘤发生的关键角色。然而,SNHG17的表达模式和生物功能在肝细胞癌(HCC)尚不清楚。生物信息学分析和存在进行检测SNHG17在肝癌组织的表达模式,相邻nontumorous组织和细胞系。SNHG17细胞增殖的影响,移民,和肝癌细胞凋亡被击倒了,overexpressing SNHG17肝癌细胞株。RNA序列被用来探索底层机制。利用公开TCGA-LIHC、GSE102079 HCC数据集和存在,我们发现SNHG17显著调节在肝癌组织和细胞系,特别是与较大的肿瘤大小有关,低分化、血管侵犯,和先进的TNM阶段。此外,增益和功能丧失的研究表明SNHG17促进细胞增殖和迁移,抑制肝癌细胞凋亡。利用RNA序列,我们发现击倒SNHG17 1037个差异表达基因引起的,高纯度的几个途径,包括代谢、PI3K-Akt,细胞粘附,调节细胞增殖、凋亡通路;其中,92人重叠在TCGA-LIHC SNHG17-related基因数据集。此外,二,TBCA、TDO2 PDK4被成功验证,发现明显在肝癌组织中特异表达。 Moreover, HCC patients with higher SNHG17 expression had a relatively poor overall survival and disease-free survival, and ERH and PDK4 also played a marked role in the prognosis of HCC. Broadly, our findings illustrate that SNHG17 acts as a noncoding oncogene in HCC progression, suggesting its potential value as a novel target for HCC therapy. SN - 2291-2789 UR - https://doi.org/10.1155/2021/9990338 DO - 10.1155/2021/9990338 JF - Canadian Journal of Gastroenterology and Hepatology PB - Hindawi KW - ER -