TY - JOUR A2 - Yu, Hangang AU - Franconi, Flavia AU - Campesi, Ilaria AU - Romani, Annalisa PY - 2020 DA - 2020/04/27 TI -特级初榨橄榄油是女性和男性心血管健康的盟友吗?SP - 6719301 VL - 2020 AB -非传染性疾病持续时间长，进展缓慢，是死亡和残疾的主要原因。这些疾病包括心血管疾病(CVD)和糖尿病(DM)，它们在世界范围内呈上升趋势，其中CVD是发达国家的主要死亡原因。因此，有必要找到新的预防和治疗方法。多酚似乎具有保护心脏的特性;其中，特级初榨橄榄油(EVOO)中的多酚和/或小极性化合物引起了人们的特别关注。考虑到心血管疾病和糖尿病中存在的众多性别差异，在这篇综述中，我们采用了“性别眼镜”。从全球范围来看，橄榄油及其衍生物具有一定的抗炎、抗氧化作用，调节糖代谢，改善内皮功能障碍。然而，就像处方药一样，在这种情况下也存在一个重要的性别偏见，因为大多数临床前研究是在雄性动物身上进行的，而细胞捐赠者的性别通常不知道;因此，临床前研究存在性别偏见。 There are numerous clinical studies that seem to suggest the benefits of EVOO and its derivatives in CVD; however, these studies have numerous limitations, presenting also a considerable heterogeneity across the interventions. Among limitations, one of the most relevant in the era of personalized medicine, is the non-attention versus women that are few and, also when they are enrolled, sex analysis is lacking. Therefore, in our opinion, it is time to perform more long, extensive and lessheterogeneous trials enrolling both women and men. SN - 1755-5914 UR - https://doi.org/10.1155/2020/6719301 DO - 10.1155/2020/6719301 JF - Cardiovascular Therapeutics PB - Hindawi KW - ER -