TY - JOUR A2 - Tayyab, Saad AU - Gopalakrishnan, Veerasamy AU - Iyyam Pillai, Subramanian AU - Subramanian, Sorimuthu Pillai PY - 2015 DA - 2015/12/09 TI - Synthesis, Spectral Characterization，高脂饲料喂养低剂量链脲佐菌素诱导大鼠实验性2型糖尿病SP - 350829 VL - 2015 AB本研究旨在评价一种新型锌-diosmin复合物在高脂饲料喂养低剂量链脲佐菌素诱导的实验性2型糖尿病大鼠中的降血糖特性。合成了锌-狄斯明配合物，并通过各种光谱研究进行了表征。ph电位滴定法和约伯图进一步证实了锌离子与狄斯敏的络合作用。糖尿病大鼠口服浓度为20 mg/kg b.w的锌-diosmin复合物。/鼠/天，30天。实验结束时，对大鼠进行口服葡萄糖耐量试验。此外，还分析了HOMA-IR和与葡萄糖稳态相关的各种生化参数。锌-diosmin复合物治疗可显著改善糖尿病大鼠的血糖稳态。通过提高蛋白质代谢和改变肌肉和肝糖原水平，锌-diosmin复合物治疗显著改善胰岛素敏感性，至少在一定程度上。 The assay of clinical marker enzymes revealed the nontoxic nature of the complex. Determination of renal tissue markers such as blood urea and serum creatinine indicates the renoprotective nature of the complex. These findings suggest that zinc-diosmin complex is nontoxic and has complimentary potential to develop as an antihyperglycemic agent for the treatment of diabetes mellitus. SN - 2090-2247 UR - https://doi.org/10.1155/2015/350829 DO - 10.1155/2015/350829 JF - Biochemistry Research International PB - Hindawi Publishing Corporation KW - ER -