TY -的A2 Biagini Giuseppe盟——Tejeda-Martinez, a . r . AU - Viveros-Paredes j . m . AU - Hidalgo-Franco g . v . AU - Pardo-Gonzalez e . AU - Chaparro-Huerta诉盟——Gonzalez-Castaneda r . e . AU - Flores-Soto m . e . PY - 2021 DA - 2021/03/25 TI -慢性FAAH减少则行为的抑制和改善齿状回扩散后慢性不可预知的压力接触SP - 6651492六世- 2021 AB -抑郁症的症状如快感缺乏和绝望的产品异常的适应压力条件。慢性不可预知的应力模型(CUS)可以生成增加-肾上腺轴(HPA)的活性和诱导减少生成信号和神经祖细胞的增殖在成年人的齿状回,一起增加氧化应激。水平的神经叫花生四烯酸乙醇胺(AEA)似乎影响这些depression-by-stress-related可以调制特性和脂肪酸酰胺水解酶(FAAH)。我们旨在评估FAAH抑制剂的影响,URB597,则行为和神经扩散的老鼠受到客户的典范。URB597是腹腔内接种剂量为0.2毫克/公斤CUS后14天。快感缺乏,则行为和绝望中评估和强迫游泳测试,分别。改变在HPA轴层面分析了使用肾上腺的相对重量和血清皮质酮水平。氧化应激和脑源性神经营养因子(BDNF)也被评估。荧光免疫组织化学测试进行的免疫反应性BrdU和Sox2 colabeling神经前体细胞的比较。URB597能够扭转则管理行为产生后在小鼠模型。 Likewise, other physiological responses associated with CUS were reduced in the treated group, among them, increase in the relative weight of the adrenal glands, increased oxidative stress, and decreased BDNF and number of neural precursors. Most of these auspicious responses to enzyme inhibitor administration were blocked by employing a cannabinoid receptor antagonist. In conclusion, the chronic inhibition of FAAH generated an antidepressant effect, promoting neural progenitor proliferation and BDNF expression, while reducing adrenal gland weight and oxidative stress in mice under the CUS model. SN - 0953-4180 UR - https://doi.org/10.1155/2021/6651492 DO - 10.1155/2021/6651492 JF - Behavioural Neurology PB - Hindawi KW - ER -