ty -jour a2 -lin，muh -shi au -al -rafiah，aziza rashed au -mehdar，Khlood Mohammed PY -2021 DA -2021/06/03 TI-组织病理学和生物化学评估神经治疗效应和脂肪素的神经保护作用癫痫SP -5549638 VL -2021 AB -pilocarpine白化大鼠大鼠模型 - 癫痫是最常见的神经系统疾病之一，其特征是以持久的倾向来产生癫痫发作。据信氧化应激直接参与导致癫痫的神经退行性途径。大约有癫痫发作的癫痫患者中有三分之一没有接受有效的医疗。丙戊酸钠（SVP）是一种常用的抗癫痫药（AED）；但是，它具有有毒作用。黄体（L）是类胡萝卜素，具有有效的抗氧化剂和抗炎特性。这项研究的目的是确定丙丙酸钠（SVP）和叶黄素（L）在毛果果石（PLC-）诱导的癫痫的大鼠模型中的神经保护作用。为了实现这一目标，将五十只老鼠随机分为五组。第I组：对照组，II组：接收PLC（400 mg/kg腹膜内），III组：接收到PLC+SVP（500 mg/kg Orally），IV组：接收到PLC+SVP+L（100 mg/kg）， and group V: received (PLC + L). Racine Scale (RC) and latency period to onset seizure were calculated. After eight weeks, the hippocampus rotarod performance and histological investigations were performed. Oxidative stress was investigated in hippocampal homogenates. Results revealed that SVP and L, given alone or in combination, reduced the RC significantly, a significant delay in latency to PLC-kindling onset, and improved rotarod performance of rats compared with the PLC group. Moreover, L was associated with a reduction of oxidative stress in hippocampal homogenate, a significant decrease in serum tumor necrosis factor-alpha (TNF- α）水平，并抑制大脑损伤并在PLC诱导的癫痫大鼠模型中表现出抗癫痫特性。从当前的研究获得的数据阐明了该模型中叶黄素的显着神经保护性，抗氧化剂和抗炎活性。总之，与AEDS的叶黄素共同治疗可能是提高患有癫痫患者的治疗功效的有前途的策略。SN -0953-4180 UR -https：//doi.org/10.1155/2021/5549638 do -10.1155/2021/5549638 JF-行为神经病学PB -Hindawi KW -er -er- ER-