TY - JOUR A2 - Piccardi，劳拉AU - 托伊奇，佩顿AU - 琼斯，卡罗琳E. AU - 凯泽，马拉E. AU - 阿瓦隆·加德纳，娜塔莎AU - 林，米兰达M. PY - 2018 DA - 二○一八年九月二十〇日TI - 步态和条件性恐惧减值在共病TBI和PTSD SP的小鼠模型 - 6037015 VL - 2018 AB - 研究目标。创伤性脑损伤（TBI）和创伤后应激障碍（PTSD）通常cooccur。途径研究和治疗这些疾病已被隔离，尽管重叠的症状。We and others have hypothesized that comorbid TBI + PTSD generates worse symptoms than either condition alone. We present a mouse model of comorbid TBI + PTSD to further explore this condition. 方法。A mouse model of TBI + PTSD was generated using the single prolonged stress (SPS) protocol in combination with the controlled cortical impact (CCI) protocol. This resulted in four experimental groups: control, TBI, PTSD, and TBI + PTSD. Behavioral phenotyping included gait analysis, contextual fear conditioning, acoustic startle response, and prepulse inhibition. 结果。Mice in the TBI + PTSD group showed a significantly impaired gait compared to their counterparts with TBI alone as well as control mice. Mice in the TBI + PTSD group showed significantly impaired contextual fear recall compared to controls. Prepulse inhibition testing revealed intact acoustic startle and auditory sensory gating. 结论。这些结果表明，SPS在小鼠CCI配对产生独特的行为障碍的步态和担心召回不存在单独任何一个条件。Further studies are underway to examine additional behavioral, physiological, and pathological phenotypes in this combined model of TBI + PTSD. SN - 0953-4180 UR - https://doi.org/10.1155/2018/6037015 DO - 10.1155/2018/6037015 JF - Behavioural Neurology PB - Hindawi KW - ER -