TY - JOUR A2 - 胡小灵AU - 李，宽义AU - 楚沛宜坳 - 皮克特，克里斯汀A. PY - 2017年DA - 2017年4月19日TI - 多巴胺能药物对关节运动学的影响时Haptic Movements in Individuals with Parkinson’s Disease SP - 2358386 VL - 2017 AB - This study examined whether altered joint angular motion during haptic exploration could account for a decline in haptic sensitivity in individuals with PD by analyzing joint position data during haptic exploration of a curved contour. Each participant’s hand was passively moved by a robotic arm along the edges of a virtual box (5 cm × 15 cm) with a curved left wall. After each trial, participants indicated whether the contour was curved or straight. Visual, auditory, and tactile cues were occluded, and an electrogoniometer recorded shoulder and elbow joint angles during each trial. The PD group in the OFF state had a higher mean detection threshold (4.67 m^-1) than the control group (3.06 m^-1）。在OFF状态PD患者也有肩外展的显著更大的幅度比处于开启状态（ p = 0.003 ）和屈肘比那些在导通状态的一个较小的幅度或相对于对照组（均 p < 0.001 ）。这些结果表明有可能有助于触觉不灵敏PD雇用的连接结构，个人。多巴胺替代疗法PD患者的触觉探索中改进的连接结构，这表明多巴胺能功能障碍在PD相关的触觉不灵敏的作用。SN - 0953-4180 UR - https://doi.org/10.1155/2017/2358386 DO - 10.1155 /二百三十五万八千三百八十六分之二千○一十七JF - 行为神经学PB - Hindawi出版KW - ER -