TY - JOUR A2 - Trojano, Luigi AU - Divac, Nevena AU - Stojanović, Radan AU - Savić Vujović, Katarina AU - Medić, Branislava AU - Damjanović, Aleksandar AU - Prostran, Milica PY - 2016 DA - 2016/07/18 TI- The Efficacy and Safety of Antipsychotic Medications in the Treatment of Psychosis in Patients with Parkinson’s Disease SP - 4938154 VL - 2016 AB - Psychotic symptoms are present in up to 50% of patients with Parkinson’s disease. These symptoms have detrimental effects on patients’ and caregivers’ quality of life and may predict mortality. The pathogenesis of psychotic symptoms in Parkinson’s disease is complex, but the use of dopaminergic medications is one of the risk factors. The treatment of psychotic symptoms in Parkinson’s disease is complicated due to the ability of antipsychotic medications to worsen motor symptoms. The efficacy of clozapine in the treatment of psychosis in patients with Parkinson’s disease has been confirmed in several clinical trials; however, the adverse effects and the necessity of blood count monitoring are the reasons why the use of this drug is challenging. The studies on safety and efficacy of other antipsychotics conflicting results. The use of antipsychotics in these patients is also associated with increased mortality. Psychotic symptoms in Parkinson’s disease 本身还被证明是死亡率的预测指标。因此，有必要治疗精神病症状，但是抗精神病药的选择应基于仔细的风险/福利评估。Pimavanserin作为一种新型的治疗选择，具有更有利的不良效果概况，但对于这种适应症而言，必须进行仔细的售后监测，以确立该药物的长期安全性和功效的真实情况。SN -0953-4180 UR -https：//doi.org/10.1155/2016/4938154 do -10.1155/2016/2016/4938154 JF-行为神经病学PB- Hindawi Publishing Corporation Corporation Corporation kw -er -er- er- er- er- er- er- er- er--