TY - JOUR A2 - He, Kaiyu AU - Xiao, Yuan-Yuan AU - Liu, Li AU - Chen, Yao AU - Zeng, Yu-Lian AU - Liu, Ming-Zhi AU - Jin, Li PY - 2016 DA - 2016/10/31 TI - Developmental Toxicity of Carbon Quantum Dots to the Embryos/Larvae of Rare Minnow (Gobiocypris rarus) SP - 4016402 VL - 2016 AB - The toxic effects of CDs on rare minnow ( Gobiocypris rarus) embryos at different developmental stages were investigated. The results showed that rare minnow embryos had decreased spontaneous movements, body length, increased heart rate, pericardial edema, yolk sac edema, tail/spinal curvature, various morphological malformations, and decreased hatching rate. Biochemical analysis showed the CDs exposure significantly inhibited the activity of Na⁺/K⁺-ATPase and Ca²⁺-ATPase and increased the MDA contents and the activity of SOD, CAT, and GPX. Further examination suggested that the CDs exposure induced serious embryonic cellular DNA damage. Moreover, the CDs exposure induced upregulation of development related genes ( Wnt8aand Mstn) along with the downregulation of Vezf1. Overall, the present study revealed that the CDs exposure has significant development toxicity on rare minnow embryos/larvae. Mechanistically, this toxicity might result from the pressure of induced oxidative stress coordinate with the dysregulated development related gene expression mediated by the CDs exposure. SN - 2314-6133 UR - https://doi.org/10.1155/2016/4016402 DO - 10.1155/2016/4016402 JF - BioMed Research International PB - Hindawi Publishing Corporation KW - ER -