TY - JOUR A2 - Molnar, Zsolt AU - Géloën, A. AU - Pichot, C. AU - Leroy, S. AU - Julien, C. AU - Ghignone, M. AU - May, C. N. AU - Quintin, L. PY - 2015 DA - 2015/12/13 TI - Pressor Response to Noradrenaline in the Setting of Septic Shock: Anything New under the Sun—Dexmedetomidine, Clonidine? A Minireview SP - 863715 VL - 2015 AB - Progress over the last 50 years has led to a decline in mortality from ≈70% to ≈20% in the best series of patients with septic shock. Nevertheless, refractory septic shock still carries a mortality close to 100%. In the best series, the mortality appears related to multiple organ failure linked to comorbidities and/or an intense inflammatory response: shortening the period that the subject is exposed to circulatory instability may further lower mortality. Treatment aims at reestablishing circulation within a “central” compartment (i.e., brain, heart, and lung) but fails to reestablish a disorganized microcirculation or an adequate response to noradrenaline, the most widely used vasopressor. Indeed, steroids, nitric oxide synthase inhibitors, or donors have not achieved overwhelming acceptance in the setting of septic shock. 违反思考那 α. ₂-Adrenoceptor激动剂被证明是在人类化粪池休克两种情况下降低去甲肾上腺素的要求。这已在败血症的大鼠和绵羊模型中复制。此外，一些数据显示 α. ₂- 一种肾上腺素能激动剂导致微循环的改善。在人体化粪池休克的情况下需要基于证据的α-2激动剂的效果。SN - 2314-6133 UR - https://doi.org/10.1155/2015/863715 Do - 10.1155 / 2015/863715 JF - 生物研究国际PB - Hindwi Publishing CorporationKW - ER -