TY - JOUR A2 - Micera, Alessandra AU - Gackowska, Lidia AU - Litwin, Mieczyslaw AU - Trojanek, Joanna AU - Eljaszewicz, Andrzej AU - Kubiszewska, Izabela AU - Niemirska, Anna AU - Wierzbicka, Aldona AU - Michalkiewicz, Jacek PY - 2015 DA - 2015/06/04 TI - Expression of Adiponectin Receptors on Peripheral Blood Leukocytes of Hypertensive Children Is Associated with the Severity of Hypertension SP - 742646 VL - 2015 AB - The aim of the study was to find out whether peripheral blood leukocyte adiponectin receptors 1 and 2 (AdipoR1, AdipoR2) protein expression patterns (flow cytometry) differ between the primary hypertension children ( n = 57 ) and healthy controls ( n = 19 ) and if their expression levels are related to selected clinical parameters. The group of 26 patients [AdipoR(−)] showed lower and the group of 31 patients [AdipoR(+)] showed higher AdipoRs protein expression than the control and each other ( P < 0.01 for neutrophils, P < 0.05 for monocytes). The AdipoR(+) leukocytes expressed higher AdipoR1 mRNA levels (RT-PCR) than AdipoR(−) ones and controls ( P = 0.022 and P = 0.007 , resp.). Despite greater BMI, the AdipoR(−) patients had unchanged serum adiponectin levels. In contrast, AdipoR(+) patients had lower serum adiponectin concentrations than the AdipoR(−) ones and controls ( P < 0.001 ). The AdipoR(+) patients had higher blood pressure ( P = 0.042 )和颈动脉内膜中层厚度大( P = 0.017 ) than the AdipoR(−) ones. The stage of hypertension was associated with increased neutrophil but not monocyte AdipoR1 density (AdipoR1 MFI) ( P < 0.05 ). Severe ambulatory hypertension was presented more often in AdipoR(+) patients than in AdipoR(−) ones (51.6% versus 26.9%, resp.; P < 0.01 ). In conclusion, neutrophil AdipoRs upregulation was associated with early stages of vascular injury, hypertension severity, and low serum levels of adiponectin. SN - 2314-6133 UR - https://doi.org/10.1155/2015/742646 DO - 10.1155/2015/742646 JF - BioMed Research International PB - Hindawi Publishing Corporation KW - ER -