TY -的A2 -劳,Julietta诉AU -彼得森Hestehave拉姆盟,拉斯穆森滨盟,Overgaard Søren AU -叮,明PY - 2015 DA - 2015/10/05 TI - P-15肽涂布羟磷灰石对胫骨缺损修复的影响体内在正常和骨质疏松性大鼠SP - 253858六世- 2015 AB -本研究评估的有效性无机的骨矿物质涂P-15肽(ABM / P-15)在正常和胫骨纵向缺陷修复骨质疏松性老鼠体内。配对设计使用。24挪威棕色老鼠分为正常和骨质疏松性组。48个圆柱形缺陷,在近端胫骨前内侧。缺陷满心反弹道导弹/ P-15或空。骨质疏松性地位被microarchitectural分析评估。Microarchitectural近端胫骨的属性在4个时间点缺陷进行评估。手术后21天,胫骨是组织学和histomorphometry收获。显著增加骨体积分数、表面密度和连接被认为在所有组14天、21天0。此外,反弹道导弹/ P-15组的结构类型是对典型的平板状结构改变。 Microarchitectural properties of ABM/P-15 treated newly formed bones at 21 days were similar in normal and osteoporotic rats. Histologically, significant bone formation was seen in all groups. Interestingly, significantly increased bone formation was seen in osteoporotic rats treated with ABM/P-15 indicating optimized healing potential. Empty defects showed lower healing potential in osteoporotic bone. In conclusion, ABM/P-15 accelerated bone regeneration in osteoporotic rats but did not enhance bone regeneration in normal rats. SN - 2314-6133 UR - https://doi.org/10.1155/2015/253858 DO - 10.1155/2015/253858 JF - BioMed Research International PB - Hindawi Publishing Corporation KW - ER -