TY - JOUR A2 - Cheung, Herman S. AU - Silva, Fernando de Sá AU - Almeida, Paula Nascimento AU - Rettore, João Vitor Paes AU - Maranduba, Claudinéia Pereira AU - Souza, Camila Maurmann de AU - Souza, Gustavo Torres de AU - Zanette, Rafaella de Souza Salomão AU - Miyagi, Sueli Patricia Harumi AU - Santos, Marcelo de Oliveira AU - Marques, Márcia Martins AU - Maranduba, Carlos Magno da Costa PY - 2012 DA - 2012/11/20 TI - Toward Personalized Cell Therapies by Using Stem Cells: Seven Relevant Topics for Safety and Success in Stem Cell Therapy SP - 758102 VL - 2012 AB - Stem cells, both embryonic and adult, due to the potential for application in tissue regeneration have been the target of interest to the world scientific community. In fact, stem cells can be considered revolutionary in the field of medicine, especially in the treatment of a wide range of human diseases. However, caution is needed in the clinical application of such cells and this is an issue that demands more studies. This paper will discuss some controversial issues of importance for achieving cell therapy safety and success. Particularly, the following aspects of stem cell biology will be presented: methods for stem cells culture, teratogenic or tumorigenic potential, cellular dose, proliferation, senescence, karyotyping, and immunosuppressive activity. SN - 2314-6133 UR - https://doi.org/10.1155/2012/758102 DO - 10.1155/2012/758102 JF - Journal of Biomedicine and Biotechnology PB - Hindawi Publishing Corporation KW - ER -