TY - JOUR A2 - Fanizzi, Francesco Paolo AU - Abeydeera, Nalin AU - Perera, Inoka C. AU - Perera, Theshini PY - 2018 DA - 2018/02/18 TI - Synthesis, Characterization, and BSA-Binding Studies of Novel Sulfonated Zinc-Triazine Complexes SP - 7563820 VL - 2018 AB - Four Zn(II) complexes containing a pyridyl triazine core ( L1 = 3-(2-pyridyl)-5,6-di(2-furyl)-1,2,4-triazine-5′,5″-disulfonic acid disodium salt and L2 = 3-(2-pyridyl)-5,6-diphenyl-1,2,4-triazine-4′,4″-disulfonic acid sodium salt) were synthesized, and their chemical formulas were finalized as [Zn(L1)Cl₂]·5H₂O·ZnCl₂( 1), [Zn(L1)₂Cl₂]·4H₂O·2CH₃OH ( 2), [Zn(L2)Cl₂]·3H₂O·CH₃OH ( 3), and [Zn(L2)₂Cl₂] ( 4). The synthesized complexes are water soluble, making them good candidates for biological applications. All four complexes have been characterized by elemental analysis and¹H NMR, IR, and UV-Vis spectroscopy. The IR stretching frequency of N=N and C=N bonds of complexes 1– 4have shifted to lower frequencies in comparison with free ligands, and a bathochromic shift was observed in UV-Vis spectra of all four complexes. The binding studies of ligands and complexes 1– 4with bovine serum albumin (BSA) resulted binding constants ( K _b) of 3.09 × 10⁴ M⁻¹, 12.30 × 10⁴ M⁻¹, and 16.84 × 10⁴ M⁻¹for ferene, complex 1, and complex 2, respectively, indicating potent serum distribution via albumins. SN - 1565-3633 UR - https://doi.org/10.1155/2018/7563820 DO - 10.1155/2018/7563820 JF - Bioinorganic Chemistry and Applications PB - Hindawi KW - ER -