TY - JOUR A2 - Casella, Luigi AU - Zhang, Xincun AU - Yue, Fan AU - Li, Hui AU - Huang, Yan AU - Zhang, Yi AU - Wen, Hongmei AU - Wang, Jide PY - 2016 DA - 2016/02/28 TI - Reversible Oxygenation ofα-Amino Acid–Cobalt(II) Complexes SP - 3585781 VL - 2016 AB - We systematically investigated the reversibility, time lapse, and oxygenation-deoxygenation properties of 15 natural α -amino acid–Co(II) complexes through UV-vis spectrophotometer, polarographic oxygen electrode, and DFT calculations, respectively, to explore the relationship between the coordinating structure and reversible oxygenation of α -amino acid–Co(II) complexes. Results revealed that the α -amino acid structure plays a key role in the reversible oxygenation properties of these complexes. The specific configuration of the α -amino acid group affects the e g 1 electron of Co(II) transfer to the π ⁎ orbit of O₂; this phenomenon also favors the reversible formation and dissociation of Co–O₂bond when O₂coordinates with Co(II) complexes. Therefore, the co-coordination of amino and carboxyl groups is a determinant of Co complexes to absorb O₂reversibly. The group adjacent to the α -amino acid unit evidently influences the dioxygen affinity and antioxidation ability of the complexes. The presence of amino (or imino) and hydroxy groups adjacent to the α -amino acid group increases the oxygenation-deoxygenation rate and the number of reversible cycles. Our findings demonstrate a new mechanism to develop reversible oxygenation complexes and to reveal the oxygenation of oxygen carriers. SN - 1565-3633 UR - https://doi.org/10.1155/2016/3585781 DO - 10.1155/2016/3585781 JF - Bioinorganic Chemistry and Applications PB - Hindawi Publishing Corporation KW - ER -