5-[(triphenylphosphonium chloride)-methyl] salicylidene-o-phenylenediamine) has been synthesized and characterized using different physicochemical methods. The binding of this complex with calf thymus (CT) DNA was investigated by circular dichroism, absorption studies, emission spectroscopy, voltammetric studies, and viscosity measurements. The results showed that this complex can bind to DNA via external and groove binding modes.">
绑定的研究一个新的水溶性铁(III)席夫碱复杂使用Multispectroscopic DNA的方法</gydF4y2Batitle>
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<p>在这一页上</p><年代p一个nclass="sc-likbZx bBmZJZ grey" property="background-color" color="#D8D8D8"><a class="sc-htpNat bUhGXt link sc-ePZHVD ewHMLz" href="#abstract" aria-label="">文摘</一个></年代p一个n><年代pan class="sc-likbZx bBmZJZ grey" property="background-color" color="#D8D8D8"><a class="sc-htpNat bUhGXt link sc-ePZHVD ewHMLz" href="#introduction" aria-label="">介绍</一个></年代p一个n><年代pan class="sc-likbZx bBmZJZ grey" property="background-color" color="#D8D8D8"><a class="sc-htpNat bUhGXt link sc-ePZHVD ewHMLz" href="#experimental" aria-label="">实验</一个></年代p一个n><年代pan class="sc-likbZx bBmZJZ grey" property="background-color" color="#D8D8D8"><a class="sc-htpNat bUhGXt link sc-ePZHVD ewHMLz" href="#results-and-discussion" aria-label="">结果与讨论</一个></年代p一个n><年代pan class="sc-likbZx bBmZJZ grey" property="background-color" color="#D8D8D8"><a class="sc-htpNat bUhGXt link sc-ePZHVD ewHMLz" href="#conclusion" aria-label="">结论</一个></年代p一个n><年代pan class="sc-likbZx bBmZJZ grey" property="background-color" color="#D8D8D8"><a class="sc-htpNat bUhGXt link sc-ePZHVD ewHMLz" href="#references" aria-label="">引用</一个></年代p一个n><年代pan class="sc-likbZx bBmZJZ grey" property="background-color" color="#D8D8D8"><a class="sc-htpNat bUhGXt link sc-ePZHVD ewHMLz" href="#copyright" aria-label="">版权</一个></年代p一个n></div>
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<p class="sc-kZmsYB bkiEfx article_type">研究文章|<gydF4y2Ba!-- -->开放获取</p><gydF4y2Badiv class="sc-RcBXQ ztvYg article_citation">
体积<gydF4y2Ba!-- -->
<!-- -->2012年<gydF4y2Ba!-- -->
<span class="sc-fZwumE cUsFHx">|</年代p一个n>文章的ID<gydF4y2Ba!-- -->
<!-- -->126451年<gydF4y2Ba!-- -->
<span class="sc-fZwumE cUsFHx">|</年代p一个n><一个class="sc-htpNat bUhGXt link sc-fQejPQ duuwge" href="https://doi.org/10.1155/2012/126451" aria-label="Doi-link">https://doi.org/10.1155/2012/126451</一个></div>
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<p>萨巴Hadidi Nahid Shahabadi,柴那Ghasemian<gydF4y2Ba!-- -->,<gydF4y2Ba!-- -->
<!-- -->”<年代p一个nclass="adjust-article-svg-size">绑定的研究一个新的水溶性铁(III)席夫碱复杂使用Multispectroscopic DNA的方法</年代p一个n>”,<gydF4y2Ba!-- --><i>生物无机化学与应用</gydF4y2Bai>,<gydF4y2Ba!-- -->
<!-- -->卷。<gydF4y2Ba!-- -->2012年<gydF4y2Ba!-- -->,<gydF4y2Ba!-- -->
<!-- -->文章的ID<gydF4y2Ba!-- -->126451年<gydF4y2Ba!-- -->,<gydF4y2Ba!-- -->
<!-- -->9<gydF4y2Ba!-- -->
<!-- -->
<!-- -->
<!-- -->页面<gydF4y2Ba!-- -->,<gydF4y2Ba!-- -->
<!-- -->2012年<gydF4y2Ba!-- -->。<gydF4y2Ba!-- -->
<!-- -->https://doi.org/10.1155/2012/126451</p></gydF4y2Badiv>
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<h1 class="sc-iRbamj jZOxOO sc-iSDuPN hHHqqR article_title adjust-article-svg-size heading-title">绑定的研究一个新的水溶性铁(III)席夫碱复杂使用Multispectroscopic DNA的方法</gydF4y2Bah1>
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<span class=""><b>Nahid Shahabadi</b><一个class="sc-htpNat bUhGXt link" href="mailto:" aria-label="Mail Option"><span class="sc-htoDjs kNoiZu sc-hjRWVT irNWJI icon-colored _2zt-1j0LmaF8UjTQAM413G icon-themeable" title="" font-size="16"></span></a>,<年代up>1</年代up></span>
<span class="">柴那Ghasemian<gydF4y2Ba!-- -->,<年代up>1</年代up>
<!-- -->和</年代p一个n><年代p一个nclass="">萨巴Hadidi<年代up>1</年代up></span>
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<p><sup>1</年代up><span>无机化学,化学学院,Razi大学科曼莎74155年,伊朗</年代p一个n></p></div>
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<b>学术编辑器:</b>gydF4y2Ba乔凡尼Natile</gydF4y2Badiv>
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<span class="articleContent__PublicationField-sc-2yl9jy-6 cIribm">收到了</年代p一个n><年代p一个nclass="articleContent__PublicationValue-sc-2yl9jy-7 khHUcu">2012年04月04</年代p一个n></div>
<div class="articleContent__PublcationCol-sc-2yl9jy-5 hgKieC notPublished">
<span class="articleContent__PublicationField-sc-2yl9jy-6 cIribm">接受</年代p一个n><年代p一个nclass="articleContent__PublicationValue-sc-2yl9jy-7 khHUcu">2012年6月11日</年代p一个n></div>
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<span class="articleContent__PublicationField-sc-2yl9jy-6 cIribm">发表</年代p一个n><年代p一个nclass="articleContent__PublicationValue-sc-2yl9jy-7 khHUcu">2012年7月31日</年代p一个n></div>
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<article class="sc-jtRlXQ hMPMVR article_body ">
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<h4 class="header" id="abstract">文摘</gydF4y2Bah4>
<p>一种新型铁(III)复杂的(Fe (SF))(克罗<年代ub>4</年代ub>)<年代ub>3</年代ub>.2H<年代ub>2</年代ub>O;科幻小说= N, N<年代ub>0</年代ub>国际清算银行<年代vgheight="13.575" id="M2" style="vertical-align:-2.26974pt;width:7.625px;" version="1.1" viewbox="0 0 7.625 13.575" width="7.625" xmlns="http://www.w3.org/2000/svg">
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<g transform="translate(72,-61.14)">
<text transform="matrix(1,0,0,-1,-71.95,63.45)">
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{</gydF4y2Batspan>
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</svg>5 -[(氯化triphenylphosphonium)甲基]salicylidene<年代vgheight="13.575" id="M3" style="vertical-align:-2.26974pt;width:7.625px;" version="1.1" viewbox="0 0 7.625 13.575" width="7.625" xmlns="http://www.w3.org/2000/svg">
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}</gydF4y2Batspan>
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</svg>-o-phenylenediamine)已经合成并使用不同的物理化学方法的特点。这个复杂的绑定与小牛胸腺DNA (CT)是由圆二色性调查,吸收研究,发射光谱学、伏安研究、和粘度测量。结果表明,这一复杂的可以通过外部结合DNA和槽绑定模式。</p><年代p一个nclass="end-abs"></span>
<h4 id="introduction">1。介绍</gydF4y2Bah4>
<p>希夫碱,以偶氮甲碱组(rc = N -),形成一个重要的类化合物在医药和医药化学和已知生物应用程序由于其抗菌(<一个href="#B1">1</一个>- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -<gydF4y2Ba一个href="#B6">6</一个>,抗真菌<一个href="#B3">3</一个>- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -<gydF4y2Ba一个href="#B6">6</一个>),和抗肿瘤<一个href="#B7">7</一个>,<gydF4y2Ba一个href="#B8">8</一个>)活动。席夫碱配体被认为是“特权配体”,因为他们很容易由醛亚胺和之间的缩合。过渡金属的结合这些化合物会导致生物活性的增强,降低细胞毒性的金属离子和席夫碱配体(<一个href="#B9">9</一个>- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -<gydF4y2Ba一个href="#B11">11</一个>]。希夫碱与捐助者(N, O S等)与中立生物系统结构相似之处,因为存在亚胺组用于阐明转化外消旋化反应的机制在生物系统<一个href="#B12">12</一个>- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -<gydF4y2Ba一个href="#B14">14</一个>]。发挥重要作用在无机化学,因为它们很容易与大多数过渡金属离子形成稳定的配合物。</p><p>gydF4y2Ba过渡金属配合物的结构多样性的席夫碱配体和由此产生的复合物的结构功能关系近年来被广泛研究的焦点(<一个href="#B15">15</一个>- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -<gydF4y2Ba一个href="#B21">21</一个>]。金属配合物已被广泛应用于诊所几个世纪以来,尽管它们的分子机制尚未完全理解(<一个href="#B22">22</一个>,<gydF4y2Ba一个href="#B23">23</一个>]。绑定和金属配合物与DNA反应被试的调查与开发新的生物技术和医学试剂(<一个href="#B24">24</一个>- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -<gydF4y2Ba一个href="#B29">30.</一个>]。理解这样的功能和设计新的dna结合金属配合物,调查的dna结合蛋白复合物的结构必然是必要的。调查在过渡金属配合物与DNA相互作用吸引了许多利益因其重要性在癌症治疗和分子生物学<一个href="#B30">31日</一个>- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -<gydF4y2Ba一个href="#B38">39</一个>]。</p><p>gydF4y2Ba众所周知,一些药物有较高的活动当管理比自由配体金属配合物<一个href="#B39">40</一个>]。其中少了铁基席夫碱配合物具有许多优于传统催化剂由于铁的丰富,无毒,廉价的性质(<一个href="#B40">41</一个>]。在这种背景下,我们研究了互动的新铁(III)复杂的席夫碱配体(图<一个href="//www.newsama.com/journals/bca/2012/126451/fig1/" target="_blank">1</一个>使用物理化学方法)与小牛胸腺DNA。</p><gydF4y2Badiv class="floats-partial-section partial-carousel-wrapper" data-section="fig1">
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<span class="caption-text">图1</年代p一个n><一个一个ria-label="full view" class="caption-partial-url" href="//www.newsama.com/journals/bca/2012/126451/fig1/" title="" target="_blank"></a>
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铁(III)的分子结构复杂。</gydF4y2Batable>
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<h4 id="experimental">2。实验</gydF4y2Bah4>
<h5 id="sec2.1">2.1。材料</gydF4y2Bah5>
<p>水杨醛,O-phenylenediamine p-formaldehyde、三苯基膦绝对乙醇、硝酸铁诺娜水合物、乙醚、二氯甲烷,乙酸乙酯,NaClO<年代ub>4</年代ub>·H<年代ub>2</年代ub>O, EDTA、Tris-HCl、氢氧化钠、乙酸钾,和氯仿从默克公司购买。双重蒸馏使用去离子水。高度聚合CT-DNA Tris-HCl缓冲区从σ购买。</p><p>gydF4y2Ba实验在Tris-HCl缓冲区进行pH值7.2。解CT-DNA了紫外吸光度比值(260除以280海里)超过1.8,表明蛋白质的DNA是充分自由。CT-DNA准备的储备溶液溶解大约1 - 2毫克的CT-DNA纤维2毫升Tris-HCl(10毫米)轻轻摇晃,储存24小时在4°C。DNA浓度(单体)股票的解决方案(<年代vgheight="14.375" id="M4" style="vertical-align:-0.3135pt;width:54.099998px;" version="1.1" viewbox="0 0 54.099998 14.375" width="54.099998" xmlns="http://www.w3.org/2000/svg">
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</svg>每个核苷酸M)是由紫外线分光光度法在适当稀释样品使用摩尔吸光系数的6600米<年代up>−1</年代up>厘米<年代up>−1</年代up>在258纳米。DNA的解决方案是使用后不超过4天。</p><gydF4y2Bah5 id="sec2.2">2.2。仪表</gydF4y2Bah5>
<p>贺利氏链进行元素分析使用元素分析仪。吸光度光谱记录使用惠普分光光度计(安捷伦8453)配有恒温浴(Huber polysat cc1)。吸收滴定实验是由复杂的浓度保持不变(<年代vgheight="14.5" id="M5" style="vertical-align:-0.3135pt;width:54.099998px;" version="1.1" viewbox="0 0 54.099998 14.5" width="54.099998" xmlns="http://www.w3.org/2000/svg">
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5</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="9.0271664" y="0">
×</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="19.804752" y="0">
1</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="26.056252" y="0">
0</gydF4y2Batspan>
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</svg>米),而不同的DNA浓度从0到<年代vgheight="14.375" id="M6" style="vertical-align:-0.3135pt;width:65.824997px;" version="1.1" viewbox="0 0 65.824997 14.375" width="65.824997" xmlns="http://www.w3.org/2000/svg">
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<g transform="translate(72,-60.5)">
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2</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="6.2515001" y="0">
。</gydF4y2Batspan>
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5</gydF4y2Batspan>
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×</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="29.182001" y="0">
1</gydF4y2Batspan>
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0</gydF4y2Batspan>
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4</gydF4y2Batspan>
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</svg>米(ri = (DNA) /(复杂的)= 0.0,0.15,0.35,0.4,0.55,0.65,和0.7)。吸光度值记录每次连续添加DNA溶液后,紧随其后的是一个平衡。CD测量记录在JASCO (j - 810)分光偏振计,DNA的浓度保持恒定(8×10<年代up>−5</年代up>米)在不同复杂的浓度(ri =(复杂的)/ (DNA) = ri = 0, 0.2, 0.4, 0.6, 0.8,和1)。粘度测量是使用粘度计(散粒AVS 450)维持在25.0±0.5°C使用恒温浴。DNA的浓度是固定在5×10<年代up>−5</年代up>M,流时间和数字秒表测量。三个测量值的平均值被用来评估粘度<年代vgheight="9.875" id="M7" style="vertical-align:-2.29482pt;width:7.9375px;" version="1.1" viewbox="0 0 7.9375 9.875" width="7.9375" xmlns="http://www.w3.org/2000/svg">
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</svg>/<年代vgheight="11.075" id="M9" style="vertical-align:-3.25793pt;width:13.4125px;" version="1.1" viewbox="0 0 13.4125 11.075" width="13.4125" xmlns="http://www.w3.org/2000/svg">
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</svg>)<年代up>1/3</年代up>,在那里<年代vgheight="9.875" id="M10" style="vertical-align:-2.29482pt;width:7.9375px;" version="1.1" viewbox="0 0 7.9375 9.875" width="7.9375" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,9.875)">
<g transform="translate(72,-64.1)">
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</svg><sub>0</年代ub>和<年代vgheight="9.875" id="M11" style="vertical-align:-2.29482pt;width:7.9375px;" version="1.1" viewbox="0 0 7.9375 9.875" width="7.9375" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,9.875)">
<g transform="translate(72,-64.1)">
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</svg>是DNA的特定粘度的贡献没有(<年代vgheight="9.875" id="M12" style="vertical-align:-2.29482pt;width:7.9375px;" version="1.1" viewbox="0 0 7.9375 9.875" width="7.9375" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,9.875)">
<g transform="translate(72,-64.1)">
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</svg><sub>0</年代ub>在复杂的存在)和(<年代vgheight="9.875" id="M13" style="vertical-align:-2.29482pt;width:7.9375px;" version="1.1" viewbox="0 0 7.9375 9.875" width="7.9375" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,9.875)">
<g transform="translate(72,-64.1)">
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</svg>),策划反对ri (ri = (DNA) /(复杂的)= 0.0,0.2,0.4,0.6,0.8,和1.0)。所有荧光测量进行了JASCO荧光光谱仪(FP6200)通过保持复杂的浓度不变而改变DNA浓度从0到5×10<年代up>−5</年代up>米(ri = (DNA) /(复杂的)= 0.0,0.08,0.16,0.32,0.4,0.48,0.55,0.62,1和1.1)在三种不同温度下(298、310和288 K)。循环伏安(CV)测量进行使用<年代vgheight="9.6750002" id="M14" style="vertical-align:-2.29482pt;width:9.6374998px;" version="1.1" viewbox="0 0 9.6374998 9.6750002" width="9.6374998" xmlns="http://www.w3.org/2000/svg">
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</svg>-AUTOLAB模型(PG STAT C),与三电极系统:0.10厘米直径玻璃碳(GC)盘作为工作电极,Ag / AgCl电极作为参比电极,和Pt线作为对电极。电化学实验进行了室温在25毫升伏安细胞。所有的潜力被称为Ag / AgCl参考。表面与0.05毫米新鲜抛光氧化铝每个实验之前,使用每个抛光步骤之间的双重蒸馏水冲洗。支持电解质为0.05 M的Tris-HCl缓冲溶液制备(pH值7.4)双重蒸馏水。电位曲线和实验数据都记录在软件1.6新星。</p><gydF4y2Bah5 id="sec2.3">2.3。铁(III)席夫碱的合成复杂</gydF4y2Bah5>
<p>大力搅拌解决方案(10毫升)的3-formyl-4 hydroxybenzyl-triphenyl磷氯(0.12 g, 2更易)首次添加铁(没有<年代ub>3</年代ub>)<年代ub>3</年代ub>h·9<年代ub>2</年代ub>O (0.136 g, 2更易)溶解在水中(10毫升)然后等<年代ub>3</年代ub>N (pH值7.5 8)。几分钟后,一个ethanolic解决方案(2毫升)的o-phenylenediamine (0.015 g, 1更易)添加了明智的下降。转向深棕色,混合物的解决方案是大力搅拌和回流3 h在氩气氛。在那之后,NaClO<年代ub>4</年代ub>·H<年代ub>2</年代ub>O(2)更易溶解在最少的水(5毫升)和添加到反应混合物。由此产生的棕色粉末沉淀被过滤收集,用冷乙醇和乙醚洗净,干空气中。复杂的是溶解在CH<年代ub>2</年代ub>Cl<年代ub>2</年代ub>(6毫升)、乙酸乙酯(3毫升)添加和最终的解决方案是允许在室温下慢慢蒸发。固体产品过滤,用乙酸乙酯和醚洗净收益率铁复杂棕色粉末。</p><gydF4y2Bah4 id="results-and-discussion">3所示。结果与讨论</gydF4y2Bah4>
<h5 id="sec3.1">3.1。铁(III)的合成和表征复杂</gydF4y2Bah5>
<p>科幻的铁(III)复杂的配体(科幻小说= N, N<年代ub>0</年代ub>bis{5 -[(氯化triphenylphosphonium)甲基]salicylidene} -o-phenylenediamine)合成了混合3-formyl-4 hydroxybenzyl-triphenyl磷氯离子,硝酸铁(III)和o-phenylenediamine高产。复杂的傅立叶变换红外光谱被记录在KBr小球从4000到400厘米<年代up>−1</年代up>。席夫碱的红外光谱特征是一个乐队的出现在3424厘米<年代up>−1</年代up>由于(OH)组(<一个href="#B41">42</一个>]。傅立叶变换红外光谱的铁(III)复杂,缺乏这个乐队表示去质子化的捐赠者和参与氧与金属原子结合。然而,强劲的乐队在ca。1627厘米<年代up>−1</年代up>分配给(CN)的席夫碱配体(<一个href="#B42">43</一个>)的变化约16厘米<年代up>−1</年代up>向低波数协调金属(<一个href="#B41">42</一个>]。因为铁(III)在本质上是顺的,其核磁共振光谱无法获得。元素分析也证实了合成的复杂。选举委员会<年代ub>58</年代ub>H<年代ub>52</年代ub>N<年代ub>2</年代ub>P<年代ub>2</年代ub>O<年代ub>16</年代ub>Cl<年代ub>3</年代ub>肛交。钙:C, 55.39;H, 4.13;2.22 N,。发现:C, 55.21;H, 4.30;2.45 N,。</p><p>复杂的电子光谱显示了乐队在260纳米是由于分子内<年代vgheight="11.7375" id="M15" style="vertical-align:-0.16302pt;width:53.837502px;" version="1.1" viewbox="0 0 53.837502 11.7375" width="53.837502" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,11.7375)">
<g transform="translate(72,-62.61)">
<text transform="matrix(1,0,0,-1,-71.95,62.83)">
<tspan style="font-size: 12.50px; " x="0" y="0">
</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="13.153156" y="0">
→</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="30.282267" y="0">
</gydF4y2Batspan>
</text>
<text transform="matrix(1,0,0,-1,-34.05,67.83)">
<tspan style="font-size: 8.75px; " x="0" y="0">
∗</gydF4y2Batspan>
</text>
</g>
</g>
</svg>过渡。另一个乐队在340海里可以归因于金属配体的电荷转移。归因于其他较弱的乐队<年代vgheight="10.75" id="M16" style="vertical-align:-0.15048pt;width:47px;" version="1.1" viewbox="0 0 47 10.75" width="47" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,10.75)">
<g transform="translate(72,-63.4)">
<text transform="matrix(1,0,0,-1,-71.95,63.6)">
<tspan style="font-size: 12.50px; " x="0" y="0">
</gydF4y2Batspan>
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→</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="30.082218" y="0">
</gydF4y2Batspan>
</text>
</g>
</g>
</svg>过渡金属中心。复杂的摩尔电导DMF是289<年代vgheight="10.6875" id="M17" style="vertical-align:-0.0pt;width:11.75px;" version="1.1" viewbox="0 0 11.75 10.6875" width="11.75" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,10.6875)">
<g transform="translate(72,-63.45)">
<text transform="matrix(1,0,0,-1,-71.95,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">
Ω</gydF4y2Batspan>
</text>
</g>
</g>
</svg><sup>−1</年代up>厘米<年代up>2</年代up>摩尔<年代up>−1</年代up>说明3:1电解的性质复杂。成键的确凿证据也显示了新乐队的观察的傅立叶变换红外光谱金属络合物在低频区出现420 - 518厘米<年代up>−1</年代up>特点——(M-O)和(mn)分别拉伸振动光谱中没有观察到自由配体。</p><gydF4y2Bah5 id="sec3.2">3.2。粘度测量</gydF4y2Bah5>
<p>水动力的方法至少长度被认为是一个敏感的绑定模式的模糊和最关键的测试解决方案没有晶体结构的数据。插层剂有望延长之间的配体的双螺旋结构,以适应基础导致DNA的粘度增加。相比之下,复杂的绑定只在DNA凹槽的部分和/或非经典的夹层,在同等条件下,通常导致不明显(正面或负面)或不改变DNA溶液粘度(<一个href="#B43">44</一个>]。的值(<年代vgheight="9.875" id="M18" style="vertical-align:-2.29482pt;width:7.9375px;" version="1.1" viewbox="0 0 7.9375 9.875" width="7.9375" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,9.875)">
<g transform="translate(72,-64.1)">
<text transform="matrix(1,0,0,-1,-71.95,66.44)">
<tspan style="font-size: 12.50px; " x="0" y="0">
</gydF4y2Batspan>
</text>
</g>
</g>
</svg>/<年代vgheight="9.875" id="M19" style="vertical-align:-2.29482pt;width:7.9375px;" version="1.1" viewbox="0 0 7.9375 9.875" width="7.9375" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,9.875)">
<g transform="translate(72,-64.1)">
<text transform="matrix(1,0,0,-1,-71.95,66.44)">
<tspan style="font-size: 12.50px; " x="0" y="0">
</gydF4y2Batspan>
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</g>
</g>
</svg><sub>0</年代ub>)<年代up>1/3</年代up>策划反对(复杂的)/ (DNA)(图<一个href="//www.newsama.com/journals/bca/2012/126451/fig2/" target="_blank">2</一个>)。增加的复杂,DNA稳步增加的相对粘度符合DNA槽绑定也知道提高DNA粘度(<一个href="#B41">42</一个>]。</p><gydF4y2Badiv class="floats-partial-section partial-carousel-wrapper" data-section="fig2">
<div class="floats-partial-content fig-content-fig2">
<div class="partial-carousel--single-image">
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<span class="caption-text">图2</年代p一个n><一个一个ria-label="full view" class="caption-partial-url" href="//www.newsama.com/journals/bca/2012/126451/fig2/" title="" target="_blank"></a>
</div>
<div class="floats-partial-caption-text">
<svg height="14.5" id="M20" style="vertical-align:-0.3135pt" version="1.1" viewbox="0 0 56.712502 14.5" width="56.712502" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.5)">
<g transform="translate(72,-60.4)">
<text transform="matrix(1,0,0,-1,-71.95,60.76)">
<tspan style="font-size: 12.50px; " x="0" y="0">
5</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="11.102664" y="0">
×</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="21.892754" y="0">
1</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="28.144253" y="0">
0</gydF4y2Batspan>
</text>
<text transform="matrix(1,0,0,-1,-37.55,65.93)">
<tspan style="font-size: 8.75px; " x="0" y="0">
−</gydF4y2Batspan>
<tspan style="font-size: 8.75px; " x="5.99512" y="0">
5</gydF4y2Batspan>
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</g>
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<table>
越来越多的复杂的铁对小牛胸腺DNA的粘度(gydF4y2Ba米)在10毫米三羟甲基氨基甲烷盐酸缓冲液(ri = 0.2, 0.4, 0.6, 0.8, 1)。</gydF4y2Batable>
</div>
</div>
</div>
<p>DNA作为夹层导致粘度显著增加解决方案由于延长DNA螺旋的碱基对是分开的,以适应绑定的芳香发色团分子,人们很容易把观察到的粘度的增加归因于intercalative交互的复杂。然而,有效的科幻的苯基环铁夹层复杂气馁几个空间因素。这种类型的空间冲突一直还建议绑定(铜(苯酚的)<年代ub>2</年代ub>]<年代up>+</年代up>和[俄文(苯酚的)<年代ub>3</年代ub>]<年代up>2 +</年代up>苯酚的配体的复合物,夹层抑制空间交互涉及其他苯酚的配体与DNA表面。因此,很明显,复杂的表面绑定更愿意参与DNA的大尺寸影响DNA粘度的增加,而不是在intercalative DNA的相互作用。槽的缓慢增加粘度表明绑定(<一个href="#B44">45</一个>,<gydF4y2Ba一个href="#B45">46</一个>]。</p><gydF4y2Bah5 id="sec3.3">3.3。CD谱研究</gydF4y2Bah5>
<p>圆二色性的光谱技术给我们有用的信息关于DNA构象的影响绑定的金属复杂的DNA。calf-thymus DNA的观察到CD谱由一个积极的乐队在277海里由于基地叠加和消极的乐队在245 nm由于螺旋性,这是右撇子B DNA的形式特征。虽然槽绑定和静电相互作用的小分子与DNA显示很少或没有扰动基础上叠加和螺旋性乐队,乐队的夹层提高强度、稳定CT-DNA的右手B构象。之间的交互复杂和CT-DNA研究了CD光谱(图<一个href="//www.newsama.com/journals/bca/2012/126451/fig3/" target="_blank">3</一个>)。</p><gydF4y2Badiv class="floats-partial-section partial-carousel-wrapper" data-section="fig3">
<div class="floats-partial-content fig-content-fig3">
<div class="partial-carousel--single-image">
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<div class="floats-partial-caption">
<span class="caption-text">图3</年代p一个n><一个一个ria-label="full view" class="caption-partial-url" href="//www.newsama.com/journals/bca/2012/126451/fig3/" title="" target="_blank"></a>
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<div class="floats-partial-caption-text">
<table></table>
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<p>在这种情况下,正面和负面的乐队的强度降低明显(转向零水平)。这表明,复杂的诱发的DNA结合特定的构象变化,比如从更多的b到c结构转换中的DNA分子(<一个href="#B46">47</一个>]。这些变化表明non-intercalative绑定模式的复杂和提供支持其槽绑定特性(<一个href="#B47">48</一个>]。</p><gydF4y2Bah5 id="sec3.4">3.4。荧光光谱</gydF4y2Bah5>
<p>淬火可以通过不同的机制来实现,通常分为动态和静态猝灭。动态猝灭是指一个过程的荧光团和饮料接触在瞬态存在的退出状态,而静态猝灭是指fluorophore-quencher复杂的形成。一般来说,动态和静态淬火可以区分他们的不同温度和激发态寿命的依赖。因为在这两种情况下,荧光强度与浓度的饮料,猝灭荧光团可以作为一个指标的淬火剂(<一个href="#B48">49</一个>]。DNA的荧光强度的影响复杂图所示<一个href="//www.newsama.com/journals/bca/2012/126451/fig4/" target="_blank">4</一个>。CT-DNA之外,降低排放强度是观察到的复杂。这意味着标题复杂与DNA有很强的交互。发光的猝灭CT-DNA可能归因于复杂的光电子转移鸟嘌呤碱基的DNA MLCT兴奋的状态,报道其他复合物(<一个href="#B49">50</一个>,<gydF4y2Ba一个href="#B50">51</一个>]。</p><gydF4y2Badiv class="floats-partial-section partial-carousel-wrapper" data-section="fig4">
<div class="floats-partial-content fig-content-fig4">
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<strong></strong>
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<span class="caption-text">图4</年代p一个n><一个一个ria-label="full view" class="caption-partial-url" href="//www.newsama.com/journals/bca/2012/126451/fig4/" title="" target="_blank"></a>
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<div class="floats-partial-caption-text">
<table></table>
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<p>荧光猝灭被Stern-Volmer方程描述:<年代p一个nclass="equation" id="EEq1">
<svg height="32.849998" id="M21" preserveaspectratio="xMaxYMin" style="vertical-align:-0pt;width:700.9375px;" version="1.1" viewbox="0 0 700.9375 32.849998" width="700.9375" xmlns="http://www.w3.org/2000/svg">
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]</gydF4y2Batspan>
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,</gydF4y2Batspan>
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</svg></span>在哪里<年代vgheight="14.3875" id="M22" style="vertical-align:-3.25793pt;width:15.875px;" version="1.1" viewbox="0 0 15.875 14.3875" width="15.875" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.3875)">
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<tspan style="font-size: 12.50px; " x="0" y="0">
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<text transform="matrix(1,0,0,-1,-64.22,60.66)">
<tspan style="font-size: 8.75px; " x="0" y="0">
0</gydF4y2Batspan>
</text>
</g>
</g>
</svg>和<gydF4y2Bai>F</gydF4y2Bai>代表了荧光强度没有在冷却器的存在,分别。<年代vgheight="13.1875" id="M23" style="vertical-align:-2.29482pt;width:19.8125px;" version="1.1" viewbox="0 0 19.8125 13.1875" width="19.8125" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,13.1875)">
<g transform="translate(72,-61.45)">
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<tspan style="font-size: 12.50px; " x="9.5272856" y="0">
</gydF4y2Batspan>
</text>
</g>
</g>
</svg>是荧光团淬火速率常数,<年代vgheight="14.3875" id="M24" style="vertical-align:-3.25792pt;width:22.387501px;" version="1.1" viewbox="0 0 22.387501 14.3875" width="22.387501" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.3875)">
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<text transform="matrix(1,0,0,-1,-62.42,60.66)">
<tspan style="font-size: 8.75px; " x="0" y="0">
年代</gydF4y2Batspan>
<tspan style="font-size: 8.75px; " x="3.4045279" y="0">
v</gydF4y2Batspan>
</text>
</g>
</g>
</svg>是猝灭常数,<年代vgheight="6.8874998" id="M25" style="vertical-align:-0.0627pt;width:8.125px;" version="1.1" viewbox="0 0 8.125 6.8874998" width="8.125" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,6.8875)">
<g transform="translate(72,-66.49)">
<text transform="matrix(1,0,0,-1,-71.95,66.6)">
<tspan style="font-size: 12.50px; " x="0" y="0">
</gydF4y2Batspan>
</text>
</g>
</g>
</svg><sub>0</年代ub>是荧光团的生命周期在缺乏冷却器(<年代vgheight="6.8874998" id="M26" style="vertical-align:-0.0627pt;width:8.125px;" version="1.1" viewbox="0 0 8.125 6.8874998" width="8.125" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,6.8875)">
<g transform="translate(72,-66.49)">
<text transform="matrix(1,0,0,-1,-71.95,66.6)">
<tspan style="font-size: 12.50px; " x="0" y="0">
</gydF4y2Batspan>
</text>
</g>
</g>
</svg><sub>0</年代ub>= 10<年代up>−8</年代up>),(Q)是饮料的浓度(<一个href="#B51">52</一个>]。动态和静态淬火可以区分他们的不同依赖温度(<一个href="#B52">53</一个>]。结果在表<一个href="//www.newsama.com/journals/bca/2012/126451/tab1/" target="_blank">1</一个>表明这个复杂的可能的猝灭机制CT-DNA涉及静态猝灭,因为<年代vgheight="14.3875" id="M27" style="vertical-align:-3.25792pt;width:22.387501px;" version="1.1" viewbox="0 0 22.387501 14.3875" width="22.387501" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.3875)">
<g transform="translate(72,-60.49)">
<text transform="matrix(1,0,0,-1,-71.95,63.79)">
<tspan style="font-size: 12.50px; " x="0" y="0">
</gydF4y2Batspan>
</text>
<text transform="matrix(1,0,0,-1,-62.42,60.66)">
<tspan style="font-size: 8.75px; " x="0" y="0">
年代</gydF4y2Batspan>
<tspan style="font-size: 8.75px; " x="3.4045279" y="0">
v</gydF4y2Batspan>
</text>
</g>
</g>
</svg>随着温度增加而减小(<一个href="#B53">54</一个>]。</p><gydF4y2Badiv class="floats-partial-section partial-other-wrapper" data-section="tab1">
<div class="floats-partial-content fig-content-tab1">
<table class="table-group" id="tab1">
<tbody>
<tr>
<td>
<table class="table">
<tbody>
<tr>
<td class="thead-hr" colspan="4">
<hr></td>
</tr>
<tr class="thead">
<td align="left">温度(<年代vgheight="10.325" id="M28" style="vertical-align:-0.0pt" version="1.1" viewbox="0 0 13.2875 10.325" width="13.2875" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,10.325)">
<g transform="translate(72,-63.74)">
<text transform="matrix(1,0,0,-1,-71.95,63.79)">
<tspan style="font-size: 12.50px; " x="0" y="0">
</gydF4y2Batspan>
</text>
</g>
</g>
</svg>)</gydF4y2Batd>
<td align="center"><span style="width: 17.7875px;">
<svg height="13.775" id="M29" style="vertical-align:-0.0pt" version="1.1" viewbox="0 0 17.7875 13.775" width="17.7875" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,13.775)">
<g transform="translate(72,-60.98)">
<text transform="matrix(1,0,0,-1,-71.95,61.03)">
<tspan style="font-size: 12.50px; " x="0" y="0">
</gydF4y2Batspan>
</text>
<text transform="matrix(1,0,0,-1,-62.7,66.03)">
<tspan style="font-size: 8.75px; " x="0" y="0">
2</gydF4y2Batspan>
</text>
</g>
</g>
</svg></span></td>
<td align="center">
<svg height="14.3875" id="M30" style="vertical-align:-3.25792pt" version="1.1" viewbox="0 0 26.424999 14.3875" width="26.424999" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.3875)">
<g transform="translate(72,-60.49)">
<text transform="matrix(1,0,0,-1,-71.95,63.79)">
<tspan style="font-size: 12.50px; " x="0" y="0">
</gydF4y2Batspan>
</text>
<text transform="matrix(1,0,0,-1,-62.42,60.66)">
<tspan style="font-size: 8.75px; " x="0" y="0">
年代</gydF4y2Batspan>
<tspan style="font-size: 8.75px; " x="4.691072" y="0">
V</gydF4y2Batspan>
</text>
</g>
</g>
</svg><br>(L摩尔<年代up>−1</年代up>)×10<年代up>4</年代up></td>
<td align="center">
<svg height="16.237499" id="M31" style="vertical-align:-4.74141pt" version="1.1" viewbox="0 0 18.1 16.237499" width="18.1" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,16.2375)">
<g transform="translate(72,-59.01)">
<text transform="matrix(1,0,0,-1,-71.95,63.79)">
<tspan style="font-size: 12.50px; " x="0" y="0">
</gydF4y2Batspan>
</text>
<text transform="matrix(1,0,0,-1,-62.42,60.66)">
<tspan style="font-size: 8.75px; " x="0" y="0">
</gydF4y2Batspan>
</text>
</g>
</g>
</svg><br>(L摩尔<年代up>−1</年代up>)×10<年代up>12</年代up></td>
</tr>
<tr>
<td class="thead-hr" colspan="4">
<hr></td>
</tr>
<tr>
<td align="left">288年</gydF4y2Batd>
<td align="center">0.992</gydF4y2Batd>
<td align="center">7.046</gydF4y2Batd>
<td align="center">7.046</gydF4y2Batd>
</tr>
<tr>
<td align="left">298年</gydF4y2Batd>
<td align="center">0.971</gydF4y2Batd>
<td align="center">6.276</gydF4y2Batd>
<td align="center">6.276</gydF4y2Batd>
</tr>
<tr>
<td align="left">310年</gydF4y2Batd>
<td align="center">0.921</gydF4y2Batd>
<td align="center">2.683</gydF4y2Batd>
<td align="center">2.683</gydF4y2Batd>
</tr>
<tr class="table-tr">
<td colspan="4">
<hr class="tbody-hr"></td>
</tr>
</tbody>
</table></td>
</tr>
</tbody>
</table>
</div>
<div class="floats-partial-footer">
<div class="floats-partial-caption">
<span class="caption-text">表1</年代p一个n><一个一个ria-label="full view" class="caption-partial-url" href="//www.newsama.com/journals/bca/2012/126451/tab1/" title="" target="_blank"></a>
</div>
<div class="floats-partial-caption-text">
猝灭常数CT-DNA铁(III)复杂的在不同的温度下。</gydF4y2Badiv>
</div>
</div>
<h6 id="sec3.4.1">3.4.1。结合常数和结合位点的数量</gydF4y2Bah6>
<p>结合常数(<年代vgheight="16.2875" id="M32" style="vertical-align:-4.77652pt;width:20.0375px;" version="1.1" viewbox="0 0 20.0375 16.2875" width="20.0375" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,16.2875)">
<g transform="translate(72,-58.97)">
<text transform="matrix(1,0,0,-1,-71.95,63.79)">
<tspan style="font-size: 12.50px; " x="0" y="0">
</gydF4y2Batspan>
</text>
<text transform="matrix(1,0,0,-1,-62.42,60.66)">
<tspan style="font-size: 8.75px; " x="0" y="0">
</gydF4y2Batspan>
</text>
</g>
</g>
</svg>)和绑定化学计量学(<年代vgheight="7.1374998" id="M33" style="vertical-align:-0.10033pt;width:7.8874998px;" version="1.1" viewbox="0 0 7.8874998 7.1374998" width="7.8874998" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,7.1375)">
<g transform="translate(72,-66.29)">
<text transform="matrix(1,0,0,-1,-71.95,66.44)">
<tspan style="font-size: 12.50px; " x="0" y="0">
</gydF4y2Batspan>
</text>
</g>
</g>
</svg>)之间的复杂的形成铁复杂和DNA测定使用(<一个href="#EEq2">2</一个>)(<gydF4y2Ba一个href="#B54">55</一个>]<gydF4y2Ba年代p一个nclass="equation" id="EEq2">
<svg height="38.575001" id="M34" preserveaspectratio="xMaxYMin" style="vertical-align:-0pt;width:700.9375px;" version="1.1" viewbox="0 0 700.9375 38.575001" width="700.9375" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,38.575)">
<g transform="translate(72,-41.14)">
<text transform="matrix(1,0,0,-1,110.88,53.45)">
<tspan style="font-size: 12.50px; " x="22.219999" y="7.3299999">
</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="32.790001" y="-9.2600002">
</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="0" y="0">
l</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="7.6393328" y="0">
o</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="13.890833" y="0">
g</gydF4y2Batspan>
</text>
<text transform="matrix(1,0,0,-1,151.4,59.58)">
<tspan style="font-size: 8.75px; " x="0" y="0">
0</gydF4y2Batspan>
</text>
<text transform="matrix(1,0,0,-1,159.05,62.71)">
<tspan style="font-size: 12.50px; " x="0" y="0">
−</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="11.340221" y="0">
</gydF4y2Batspan>
</text>
<g>
<path d="m 143.67,56.57 36.27,0" style="fill:none;stroke:#000000;stroke-width:0.82499999;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:10;stroke-opacity:1;stroke-dasharray:none"></path>
</g>
<text transform="matrix(1,0,0,-1,157.04,44.69)">
<tspan style="font-size: 12.50px; " x="0" y="0">
</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="24.09" y="-1.4299999">
</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="36.939999" y="-8.7600002">
=</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="48.980389" y="-8.7600002">
l</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="56.61972" y="-8.7600002">
o</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="62.871223" y="-8.7600002">
g</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="69.122719" y="-8.7600002">
</gydF4y2Batspan>
</text>
<text transform="matrix(1,0,0,-1,235.69,50.32)">
<tspan style="font-size: 8.75px; " x="0" y="0">
</gydF4y2Batspan>
</text>
<text transform="matrix(1,0,0,-1,244.87,53.45)">
<tspan style="font-size: 12.50px; " x="39.790001" y="0.039999999">
(</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="43.950001" y="0">
</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="53.720001" y="0.039999999">
]</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="0" y="0">
+</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="11.340221" y="0">
</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="17.554213" y="0">
l</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="25.193544" y="0">
o</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="31.445045" y="0">
g</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="59.959999" y="0">
。</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="229.25" y="0">
(</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="233.4135" y="0">
2</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="239.66499" y="0">
)</gydF4y2Batspan>
</text>
</g>
</g>
</svg></span>在这里,<年代vgheight="14.3875" id="M35" style="vertical-align:-3.25793pt;width:15.875px;" version="1.1" viewbox="0 0 15.875 14.3875" width="15.875" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.3875)">
<g transform="translate(72,-60.49)">
<text transform="matrix(1,0,0,-1,-71.95,63.79)">
<tspan style="font-size: 12.50px; " x="0" y="0">
</gydF4y2Batspan>
</text>
<text transform="matrix(1,0,0,-1,-64.22,60.66)">
<tspan style="font-size: 8.75px; " x="0" y="0">
0</gydF4y2Batspan>
</text>
</g>
</g>
</svg>和<gydF4y2Bai>F</gydF4y2Bai>荧光团的荧光强度在不同浓度的缺失和存在CT-DNA,分别。的值<年代vgheight="16.2875" id="M36" style="vertical-align:-4.77652pt;width:20.0375px;" version="1.1" viewbox="0 0 20.0375 16.2875" width="20.0375" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,16.2875)">
<g transform="translate(72,-58.97)">
<text transform="matrix(1,0,0,-1,-71.95,63.79)">
<tspan style="font-size: 12.50px; " x="0" y="0">
</gydF4y2Batspan>
</text>
<text transform="matrix(1,0,0,-1,-62.42,60.66)">
<tspan style="font-size: 8.75px; " x="0" y="0">
</gydF4y2Batspan>
</text>
</g>
</g>
</svg>aaa和<年代vgheight="7.1374998" id="M37" style="vertical-align:-0.10033pt;width:7.8874998px;" version="1.1" viewbox="0 0 7.8874998 7.1374998" width="7.8874998" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,7.1375)">
<g transform="translate(72,-66.29)">
<text transform="matrix(1,0,0,-1,-71.95,66.44)">
<tspan style="font-size: 12.50px; " x="0" y="0">
</gydF4y2Batspan>
</text>
</g>
</g>
</svg>被发现是3.54×10吗<年代up>4</年代up>米<年代up>−1</年代up>分别和0.64(表<一个href="//www.newsama.com/journals/bca/2012/126451/tab2/" target="_blank">2</一个>)。</p><gydF4y2Badiv class="floats-partial-section partial-other-wrapper" data-section="tab2">
<div class="floats-partial-content fig-content-tab2">
<table class="table-group" id="tab2">
<tbody>
<tr>
<td>
<table class="table">
<tbody>
<tr>
<td class="thead-hr" colspan="6">
<hr></td>
</tr>
<tr class="thead">
<td align="left">温度(<年代vgheight="10.325" id="M40" style="vertical-align:-0.0pt" version="1.1" viewbox="0 0 13.2875 10.325" width="13.2875" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,10.325)">
<g transform="translate(72,-63.74)">
<text transform="matrix(1,0,0,-1,-71.95,63.79)">
<tspan style="font-size: 12.50px; " x="0" y="0">
</gydF4y2Batspan>
</text>
</g>
</g>
</svg>)</gydF4y2Batd>
<td align="center">线性方程</gydF4y2Batd>
<td align="center"><span style="width: 17.7875px;">
<svg height="13.775" id="M41" style="vertical-align:-0.0pt" version="1.1" viewbox="0 0 17.7875 13.775" width="17.7875" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,13.775)">
<g transform="translate(72,-60.98)">
<text transform="matrix(1,0,0,-1,-71.95,61.03)">
<tspan style="font-size: 12.50px; " x="0" y="0">
</gydF4y2Batspan>
</text>
<text transform="matrix(1,0,0,-1,-62.7,66.03)">
<tspan style="font-size: 8.75px; " x="0" y="0">
2</gydF4y2Batspan>
</text>
</g>
</g>
</svg></span></td>
<td align="center"><span style="width: 7.8874998px;">
<svg height="7.1374998" id="M42" style="vertical-align:-0.10033pt" version="1.1" viewbox="0 0 7.8874998 7.1374998" width="7.8874998" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,7.1375)">
<g transform="translate(72,-66.29)">
<text transform="matrix(1,0,0,-1,-71.95,66.44)">
<tspan style="font-size: 12.50px; " x="0" y="0">
</gydF4y2Batspan>
</text>
</g>
</g>
</svg></span></td>
<td align="center"><span style="width: 20.0375px;">
<svg height="16.2875" id="M43" style="vertical-align:-4.77652pt" version="1.1" viewbox="0 0 20.0375 16.2875" width="20.0375" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,16.2875)">
<g transform="translate(72,-58.97)">
<text transform="matrix(1,0,0,-1,-71.95,63.79)">
<tspan style="font-size: 12.50px; " x="0" y="0">
</gydF4y2Batspan>
</text>
<text transform="matrix(1,0,0,-1,-62.42,60.66)">
<tspan style="font-size: 8.75px; " x="0" y="0">
</gydF4y2Batspan>
</text>
</g>
</g>
</svg></span></td>
<td align="center"><span style="width: 45.224998px;">
<svg height="16.424999" id="M44" style="vertical-align:-4.77652pt" version="1.1" viewbox="0 0 45.224998 16.424999" width="45.224998" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,16.425)">
<g transform="translate(72,-58.86)">
<text transform="matrix(1,0,0,-1,-71.95,63.67)">
<tspan style="font-size: 12.50px; " x="0" y="0">
l</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="7.6393328" y="0">
o</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="13.890833" y="0">
g</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="20.142332" y="0">
</gydF4y2Batspan>
</text>
<text transform="matrix(1,0,0,-1,-42.28,60.55)">
<tspan style="font-size: 8.75px; " x="0" y="0">
</gydF4y2Batspan>
</text>
</g>
</g>
</svg></span></td>
</tr>
<tr>
<td class="thead-hr" colspan="6">
<hr></td>
</tr>
<tr>
<td align="left">288年</gydF4y2Batd>
<td align="center"><i>Y</gydF4y2Bai>= 1.678<gydF4y2Bai>X</gydF4y2Bai>+ 8.176</gydF4y2Batd>
<td align="center">0.990</gydF4y2Batd>
<td align="center">1.678</gydF4y2Batd>
<td align="center">1.49×10<年代up>8</年代up></td>
<td align="center">8.176</gydF4y2Batd>
</tr>
<tr>
<td align="left">298年</gydF4y2Batd>
<td align="center"><i>Y</gydF4y2Bai>= 0.644<gydF4y2Bai>X</gydF4y2Bai>+ 4.549</gydF4y2Batd>
<td align="center">0.987</gydF4y2Batd>
<td align="center">0.644</gydF4y2Batd>
<td align="center">3.54×10<年代up>4</年代up></td>
<td align="center">4.549</gydF4y2Batd>
</tr>
<tr>
<td align="left">310年</gydF4y2Batd>
<td align="center"><i>Y</gydF4y2Bai>= 0.527<gydF4y2Bai>X</gydF4y2Bai>+ 2.293</gydF4y2Batd>
<td align="center">0.957</gydF4y2Batd>
<td align="center">0.527</gydF4y2Batd>
<td align="center">1.96×10<年代up>2</年代up></td>
<td align="center">2.293</gydF4y2Batd>
</tr>
<tr class="table-tr">
<td colspan="6">
<hr class="tbody-hr"></td>
</tr>
</tbody>
</table></td>
</tr>
</tbody>
</table>
</div>
<div class="floats-partial-footer">
<div class="floats-partial-caption">
<span class="caption-text">表2</年代p一个n><一个一个ria-label="full view" class="caption-partial-url" href="//www.newsama.com/journals/bca/2012/126451/tab2/" title="" target="_blank"></a>
</div>
<div class="floats-partial-caption-text">
绑定常量(<年代vgheight="16.2875" id="M38" style="vertical-align:-4.77652pt" version="1.1" viewbox="0 0 20.0375 16.2875" width="20.0375" xmlns="http://www.w3.org/2000/svg">
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</svg>)和结合位点的数量(<年代vgheight="7.1374998" id="M39" style="vertical-align:-0.10033pt" version="1.1" viewbox="0 0 7.8874998 7.1374998" width="7.8874998" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,7.1375)">
<g transform="translate(72,-66.29)">
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</g>
</g>
</svg>DNA)的复杂系统。</gydF4y2Badiv>
</div>
</div>
<h6 id="sec3.4.2">3.4.2。复杂和DNA之间的绑定模式</gydF4y2Bah6>
<p>根据热力学数据,解释如下,药物与生物分子相互作用的模型可以(<一个href="#B55">56</一个>]:<年代vgheight="13.45" id="M45" style="vertical-align:-2.21957pt;width:18.35px;" version="1.1" viewbox="0 0 18.35 13.45" width="18.35" xmlns="http://www.w3.org/2000/svg">
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<svg height="10.6625" id="M46" style="vertical-align:-0.0pt;width:11.4125px;" version="1.1" viewbox="0 0 11.4125 10.6625" width="11.4125" xmlns="http://www.w3.org/2000/svg">
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</svg><i>年代</gydF4y2Bai>
<svg height="8.8500004" id="M49" style="vertical-align:-0.30096pt;width:10.825px;" version="1.1" viewbox="0 0 10.825 8.8500004" width="10.825" xmlns="http://www.w3.org/2000/svg">
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<svg height="8.8500004" id="M51" style="vertical-align:-0.30096pt;width:10.825px;" version="1.1" viewbox="0 0 10.825 8.8500004" width="10.825" xmlns="http://www.w3.org/2000/svg">
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<svg height="8.8500004" id="M53" style="vertical-align:-0.30096pt;width:10.825px;" version="1.1" viewbox="0 0 10.825 8.8500004" width="10.825" xmlns="http://www.w3.org/2000/svg">
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</svg>0,范德华相互作用和氢键;<年代vgheight="13.45" id="M54" style="vertical-align:-2.21957pt;width:34.837502px;" version="1.1" viewbox="0 0 34.837502 13.45" width="34.837502" xmlns="http://www.w3.org/2000/svg">
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)</gydF4y2Batspan>
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</svg><i>H</gydF4y2Bai>
<svg height="8.8500004" id="M55" style="vertical-align:-0.30096pt;width:10.825px;" version="1.1" viewbox="0 0 10.825 8.8500004" width="10.825" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,8.85)">
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</svg>0和<年代vgheight="10.6625" id="M56" style="vertical-align:-0.0pt;width:11.4125px;" version="1.1" viewbox="0 0 11.4125 10.6625" width="11.4125" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,10.6625)">
<g transform="translate(72,-63.47)">
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<tspan style="font-size: 12.50px; " x="0" y="0">
Δ</gydF4y2Batspan>
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</svg><i>年代</gydF4y2Bai>
<svg height="8.8500004" id="M57" style="vertical-align:-0.30096pt;width:10.825px;" version="1.1" viewbox="0 0 10.825 8.8500004" width="10.825" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,8.85)">
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</g>
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</svg>0,静电相互作用[<一个href="#B56">57</一个>]。为了阐明我们复杂的与DNA的相互作用的热力学参数进行了计算。ln的情节<gydF4y2Bai>K</gydF4y2Bai>和1 /<gydF4y2Bai>T</gydF4y2Bai>(图<一个href="//www.newsama.com/journals/bca/2012/126451/fig5/" target="_blank">5</一个>;(<一个href="#EEq3">3</一个>)允许的决心<年代vgheight="10.6625" id="M58" style="vertical-align:-0.0pt;width:11.4125px;" version="1.1" viewbox="0 0 11.4125 10.6625" width="11.4125" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,10.6625)">
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<tspan style="font-size: 12.50px; " x="0" y="0">
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</svg><i>H</gydF4y2Bai>和<年代vgheight="10.6625" id="M59" style="vertical-align:-0.0pt;width:11.4125px;" version="1.1" viewbox="0 0 11.4125 10.6625" width="11.4125" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,10.6625)">
<g transform="translate(72,-63.47)">
<text transform="matrix(1,0,0,-1,-71.95,63.52)">
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</svg><i>年代</gydF4y2Bai>。如果温度不发生显著的变化,焓的变化可以被看作是一个常数。根据绑定常数在不同的温度下,可以估计(表的自由能变化<一个href="//www.newsama.com/journals/bca/2012/126451/tab3/" target="_blank">3</一个>;(<一个href="#EEq4">4</一个>)由以下方程<年代p一个nclass="equation" id="EEq3">
<svg height="58.287498" id="M60" preserveaspectratio="xMaxYMin" style="vertical-align:-0pt;width:700.9375px;" version="1.1" viewbox="0 0 700.9375 58.287498" width="700.9375" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,58.2875)">
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<g transform="matrix(1.25,0,0,-1.25,0,10.6625)">
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<text transform="matrix(1,0,0,-1,-71.95,63.52)">
<tspan style="font-size: 12.50px; " x="0" y="0">
Δ</gydF4y2Batspan>
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</svg><i>H</gydF4y2Bai>
<svg height="8.8500004" id="M62" style="vertical-align:-0.30096pt;width:10.825px;" version="1.1" viewbox="0 0 10.825 8.8500004" width="10.825" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,8.85)">
<g transform="translate(72,-64.92)">
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<g transform="matrix(1.25,0,0,-1.25,0,10.6625)">
<g transform="translate(72,-63.47)">
<text transform="matrix(1,0,0,-1,-71.95,63.52)">
<tspan style="font-size: 12.50px; " x="0" y="0">
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</g>
</g>
</svg><i>年代</gydF4y2Bai>
<svg height="8.8500004" id="M64" style="vertical-align:-0.30096pt;width:10.825px;" version="1.1" viewbox="0 0 10.825 8.8500004" width="10.825" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,8.85)">
<g transform="translate(72,-64.92)">
<text transform="matrix(1,0,0,-1,-71.95,65.27)">
<tspan style="font-size: 12.50px; " x="0" y="0">
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</text>
</g>
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</svg>0。因此,范德瓦耳斯相互作用或氢键可能是主力的绑定CT-DNA题为复杂。</p><gydF4y2Badiv class="floats-partial-section partial-other-wrapper" data-section="tab3">
<div class="floats-partial-content fig-content-tab3">
<table class="table-group" id="tab3">
<tbody>
<tr>
<td>
<table class="table">
<tbody>
<tr>
<td class="thead-hr" colspan="4">
<hr></td>
</tr>
<tr class="thead">
<td align="left">温度(<年代vgheight="10.325" id="M65" style="vertical-align:-0.0pt" version="1.1" viewbox="0 0 13.2875 10.325" width="13.2875" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,10.325)">
<g transform="translate(72,-63.74)">
<text transform="matrix(1,0,0,-1,-71.95,63.79)">
<tspan style="font-size: 12.50px; " x="0" y="0">
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</text>
</g>
</g>
</svg>)</gydF4y2Batd>
<td align="center">
<svg height="10.85" id="M66" style="vertical-align:-0.15048pt" version="1.1" viewbox="0 0 23.1875 10.85" width="23.1875" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,10.85)">
<g transform="translate(72,-63.32)">
<text transform="matrix(1,0,0,-1,-71.95,63.52)">
<tspan style="font-size: 12.50px; " x="0" y="0">
Δ</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="9.0271664" y="0">
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</text>
</g>
</g>
</svg><br>(KJ摩尔<年代up>−1</年代up>)</gydF4y2Batd>
<td align="center">
<svg height="10.6625" id="M67" style="vertical-align:-0.0pt" version="1.1" viewbox="0 0 26.4625 10.6625" width="26.4625" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,10.6625)">
<g transform="translate(72,-63.47)">
<text transform="matrix(1,0,0,-1,-71.95,63.52)">
<tspan style="font-size: 12.50px; " x="0" y="0">
Δ</gydF4y2Batspan>
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</g>
</g>
</svg><br>(KJ摩尔<年代up>−1</年代up>)</gydF4y2Batd>
<td align="center">
<svg height="10.8125" id="M68" style="vertical-align:-0.1254pt" version="1.1" viewbox="0 0 22.6625 10.8125" width="22.6625" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,10.8125)">
<g transform="translate(72,-63.35)">
<text transform="matrix(1,0,0,-1,-71.95,63.52)">
<tspan style="font-size: 12.50px; " x="0" y="0">
Δ</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="9.0271664" y="0">
</gydF4y2Batspan>
</text>
</g>
</g>
</svg><br>(J摩尔<年代up>−1</年代up>K<年代up>−1</年代up>)</gydF4y2Batd>
</tr>
<tr>
<td class="thead-hr" colspan="4">
<hr></td>
</tr>
<tr>
<td align="left">283年</gydF4y2Batd>
<td align="center">−21.99</gydF4y2Batd>
<td align="center">−197.45</gydF4y2Batd>
<td align="center">−620.05</gydF4y2Batd>
</tr>
<tr>
<td align="left">299年</gydF4y2Batd>
<td align="center">−12.07</gydF4y2Batd>
<td align="center">−197.45</gydF4y2Batd>
<td align="center">−620.05</gydF4y2Batd>
</tr>
<tr>
<td align="left">310年</gydF4y2Batd>
<td align="center">−5.25</gydF4y2Batd>
<td align="center">−197.45</gydF4y2Batd>
<td align="center">−620.05</gydF4y2Batd>
</tr>
<tr class="table-tr">
<td colspan="4">
<hr class="tbody-hr"></td>
</tr>
</tbody>
</table></td>
</tr>
</tbody>
</table>
</div>
<div class="floats-partial-footer">
<div class="floats-partial-caption">
<span class="caption-text">表3</年代p一个n><一个一个ria-label="full view" class="caption-partial-url" href="//www.newsama.com/journals/bca/2012/126451/tab3/" title="" target="_blank"></a>
</div>
<div class="floats-partial-caption-text">
热力学参数的绑定和绑定常量铁(III)复杂的小牛胸腺DNA。</gydF4y2Badiv>
</div>
</div>
<div class="floats-partial-section partial-carousel-wrapper" data-section="fig5">
<div class="floats-partial-content fig-content-fig5">
<div class="partial-carousel--single-image">
<img alt="" name="126451.fig.005" src="https://static-01.hindawi.com/articles/bca/volume-2012/126451/figures/126451.fig.005.jpg">
<br>
<strong></strong>
</div>
</div>
<div class="floats-partial-footer">
<div class="floats-partial-caption">
<span class="caption-text">图5</年代p一个n><一个一个ria-label="full view" class="caption-partial-url" href="//www.newsama.com/journals/bca/2012/126451/fig5/" title="" target="_blank"></a>
</div>
<div class="floats-partial-caption-text">
<table></table>
</div>
</div>
</div>
<h5 id="sec3.5">3.5。吸收的研究</gydF4y2Bah5>
<p>电子吸收光谱是一种有效的方法来检查绑定模式的DNA与金属配合物。一般来说,减色性和红移与绑定相关联的复杂的螺旋intercalative模式涉及的强烈叠加交互芳香发色团之间的复杂的DNA碱基对。图<一个href="//www.newsama.com/journals/bca/2012/126451/fig6/" target="_blank">6</一个>的紫外吸收光谱显示复杂的没有和DNA的存在。紫外线地区从200年到400海里,复杂有很强的吸收峰在260 nm,除了肩带约340海里。复杂的样品的吸收强度增加(hyperchromism;% H = 37.3%),没有明显红移后的DNA,这表明DNA之间的相互作用和复杂。复杂的hyperchromism,添加calf-thymus DNA,意味着在本质上是non-intercalative绑定模式。这hyperchromism可以归因于外部联系与双工(表面绑定)。一些类似hyperchromism已经观察到(<一个href="#B57">58</一个>- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -- - - - - -<gydF4y2Ba一个href="#B59">60</一个>]。但是这需要进一步澄清的DNA结合模式复杂的粘度测量。</p><gydF4y2Badiv class="floats-partial-section partial-carousel-wrapper" data-section="fig6">
<div class="floats-partial-content fig-content-fig6">
<div class="partial-carousel--single-image">
<img alt="" name="126451.fig.006" src="https://static-01.hindawi.com/articles/bca/volume-2012/126451/figures/126451.fig.006.jpg">
<br>
<strong></strong>
</div>
</div>
<div class="floats-partial-footer">
<div class="floats-partial-caption">
<span class="caption-text">图6</年代p一个n><一个一个ria-label="full view" class="caption-partial-url" href="//www.newsama.com/journals/bca/2012/126451/fig6/" title="" target="_blank"></a>
</div>
<div class="floats-partial-caption-text">
<table></table>
</div>
</div>
</div>
<p>吸收数据进行分析评估的内在约束力的常数,<年代vgheight="14.3625" id="M69" style="vertical-align:-3.2316pt;width:17.799999px;" version="1.1" viewbox="0 0 17.799999 14.3625" width="17.799999" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.3625)">
<g transform="translate(72,-60.51)">
<text transform="matrix(1,0,0,-1,-71.95,63.79)">
<tspan style="font-size: 12.50px; " x="0" y="0">
</gydF4y2Batspan>
</text>
<text transform="matrix(1,0,0,-1,-62.42,60.66)">
<tspan style="font-size: 8.75px; " x="0" y="0">
</gydF4y2Batspan>
</text>
</g>
</g>
</svg>可以确定(<一个href="#EEq5">5</一个>)(<gydF4y2Ba一个href="#B60">61年</一个>),<gydF4y2Ba年代p一个nclass="equation" id="EEq5">
<svg height="35.625" id="M70" preserveaspectratio="xMaxYMin" style="vertical-align:-0pt;width:700.9375px;" version="1.1" viewbox="0 0 700.9375 35.625" width="700.9375" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,35.625)">
<g transform="translate(72,-43.5)">
<text transform="matrix(1,0,0,-1,115.89,63.49)">
<tspan style="font-size: 12.50px; " x="0" y="0">
(</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="31.02" y="0">
]</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="4.1599998" y="-0.029999999">
D</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="13.187166" y="-0.029999999">
N</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="22.001781" y="-0.029999999">
一个</gydF4y2Batspan>
</text>
<g>
<path d="m 108.85,58.65 49.26,0" style="fill:none;stroke:#000000;stroke-width:0.82499999;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:10;stroke-opacity:1;stroke-dasharray:none"></path>
</g>
<text transform="matrix(1,0,0,-1,108.85,46.78)">
<tspan style="font-size: 12.50px; " x="0" y="0">
(</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="53.93" y="-8.7399998">
=</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="74.199997" y="-16.709999">
(</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="105.22" y="-16.709999">
]</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="4.1599998" y="0.0099999998">
</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="10.211452" y="0.0099999998">
</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="19.263624" y="0.0099999998">
−</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="30.603846" y="0.0099999998">
</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="36.655296" y="0.0099999998">
</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="45.094822" y="0.0099999998">
)</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="78.360001" y="-16.74">
D</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="87.387169" y="-16.74">
N</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="96.189278" y="-16.74">
一个</gydF4y2Batspan>
</text>
<g>
<path d="m 176.02,58.65 49.24,0" style="fill:none;stroke:#000000;stroke-width:0.82499999;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:10;stroke-opacity:1;stroke-dasharray:none"></path>
</g>
<text transform="matrix(1,0,0,-1,176.02,46.78)">
<tspan style="font-size: 12.50px; " x="0" y="0">
(</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="53.209999" y="-8.7399998">
+</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="95.169998" y="-15.99">
1</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="4.1599998" y="0.0099999998">
</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="10.211452" y="0.0099999998">
0</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="19.238619" y="0.0099999998">
−</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="30.578838" y="0.0099999998">
</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="36.630291" y="0.0099999998">
</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="45.069817" y="0.0099999998">
)</gydF4y2Batspan>
</text>
<g>
<path d="m 241.77,58.65 65.09,0" style="fill:none;stroke:#000000;stroke-width:0.82499999;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:10;stroke-opacity:1;stroke-dasharray:none"></path>
</g>
<text transform="matrix(1,0,0,-1,241.77,46.77)">
<tspan style="font-size: 12.50px; " x="0" y="0">
</gydF4y2Batspan>
</text>
<text transform="matrix(1,0,0,-1,251.3,43.64)">
<tspan style="font-size: 8.75px; " x="0" y="0">
</gydF4y2Batspan>
</text>
<text transform="matrix(1,0,0,-1,257.99,46.78)">
<tspan style="font-size: 12.50px; " x="0" y="0">
(</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="50.07" y="-8.7399998">
,</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="4.1700001" y="0.0099999998">
</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="10.221452" y="0.0099999998">
</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="18.873528" y="0.0099999998">
−</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="30.213749" y="0.0099999998">
</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="36.265202" y="0.0099999998">
</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="44.704727" y="0.0099999998">
)</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="216.13" y="-7.8400002">
(</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="220.2935" y="-7.8400002">
5</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="226.545" y="-7.8400002">
)</gydF4y2Batspan>
</text>
</g>
</g>
</svg></span>在(DNA)的浓度DNA碱基对,明显的吸收系数<gydF4y2Bai><i>ε</gydF4y2Bai>一个</gydF4y2Bai>,<gydF4y2Bai><i>ε</gydF4y2Bai>f</gydF4y2Bai>和<gydF4y2Bai><i>ε</gydF4y2Bai>b</gydF4y2Bai>对应于一个<gydF4y2Bai>obsd</gydF4y2Bai>的消光系数/ [M],免费的化合物和化合物的消光系数完全绑定到DNA时,分别。</p><p>gydF4y2Ba在块(DNA) / (<gydF4y2Bai><i>ε</gydF4y2Bai>一个</gydF4y2Bai>−<gydF4y2Bai><i>ε</gydF4y2Bai>f</gydF4y2Bai>)与(DNA),<年代vgheight="14.3625" id="M71" style="vertical-align:-3.2316pt;width:17.799999px;" version="1.1" viewbox="0 0 17.799999 14.3625" width="17.799999" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.3625)">
<g transform="translate(72,-60.51)">
<text transform="matrix(1,0,0,-1,-71.95,63.79)">
<tspan style="font-size: 12.50px; " x="0" y="0">
</gydF4y2Batspan>
</text>
<text transform="matrix(1,0,0,-1,-62.42,60.66)">
<tspan style="font-size: 8.75px; " x="0" y="0">
</gydF4y2Batspan>
</text>
</g>
</g>
</svg>是由拦截斜率的比值。内在bindingconstant,<年代vgheight="14.3625" id="M72" style="vertical-align:-3.2316pt;width:17.799999px;" version="1.1" viewbox="0 0 17.799999 14.3625" width="17.799999" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.3625)">
<g transform="translate(72,-60.51)">
<text transform="matrix(1,0,0,-1,-71.95,63.79)">
<tspan style="font-size: 12.50px; " x="0" y="0">
</gydF4y2Batspan>
</text>
<text transform="matrix(1,0,0,-1,-62.42,60.66)">
<tspan style="font-size: 8.75px; " x="0" y="0">
</gydF4y2Batspan>
</text>
</g>
</g>
</svg>复杂的是9×10<年代up>4</年代up>米<年代up>−1</年代up>(图<一个href="//www.newsama.com/journals/bca/2012/126451/fig7/" target="_blank">7</一个>)。</p><gydF4y2Badiv class="floats-partial-section partial-carousel-wrapper" data-section="fig7">
<div class="floats-partial-content fig-content-fig7">
<div class="partial-carousel--single-image">
<img alt="" name="126451.fig.007" src="https://static-01.hindawi.com/articles/bca/volume-2012/126451/figures/126451.fig.007.jpg">
<br>
<strong></strong>
</div>
</div>
<div class="floats-partial-footer">
<div class="floats-partial-caption">
<span class="caption-text">图7</年代p一个n><一个一个ria-label="full view" class="caption-partial-url" href="//www.newsama.com/journals/bca/2012/126451/fig7/" title="" target="_blank"></a>
</div>
<div class="floats-partial-caption-text">
<table></table>
</div>
</div>
</div>
<p>的<年代vgheight="14.3625" id="M73" style="vertical-align:-3.2316pt;width:17.799999px;" version="1.1" viewbox="0 0 17.799999 14.3625" width="17.799999" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.3625)">
<g transform="translate(72,-60.51)">
<text transform="matrix(1,0,0,-1,-71.95,63.79)">
<tspan style="font-size: 12.50px; " x="0" y="0">
</gydF4y2Batspan>
</text>
<text transform="matrix(1,0,0,-1,-62.42,60.66)">
<tspan style="font-size: 8.75px; " x="0" y="0">
</gydF4y2Batspan>
</text>
</g>
</g>
</svg>这里获得的价值低于报告古典intercalators(溴化乙锭和[俄文(苯酚的)DPPZ]的绑定常量被发现在10<年代up>6</年代up>-10年<年代up>7</年代up>米)(<一个href="#B61">62年</一个>,<gydF4y2Ba一个href="#B62">63年</一个>]。观察到的结合常数是更符合槽绑定与DNA,观察到的文献[<一个href="#B63">64年</一个>]。</p><p>gydF4y2Ba的<年代vgheight="14.3625" id="M74" style="vertical-align:-3.2316pt;width:17.799999px;" version="1.1" viewbox="0 0 17.799999 14.3625" width="17.799999" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.3625)">
<g transform="translate(72,-60.51)">
<text transform="matrix(1,0,0,-1,-71.95,63.79)">
<tspan style="font-size: 12.50px; " x="0" y="0">
</gydF4y2Batspan>
</text>
<text transform="matrix(1,0,0,-1,-62.42,60.66)">
<tspan style="font-size: 8.75px; " x="0" y="0">
</gydF4y2Batspan>
</text>
</g>
</g>
</svg>值的复杂与观察等一些复合物,[有限公司(苯酚的)<年代ub>3</年代ub>]<年代up>3 +</年代up>(1.6×10<年代up>4</年代up>米<年代up>−1</年代up>)[<一个href="#B64">65年</一个>];[俄文(苯酚的)<年代ub>3</年代ub>)<年代up>2 +</年代up>)(0.55×10<年代up>4</年代up>米<年代up>−1</年代up>)[<一个href="#B65">66年</一个>];(俄文(苯酚的)<年代ub>2</年代ub>(bpy)] (PF<年代ub>6</年代ub>)<年代ub>2</年代ub>(0.36×10<年代up>4</年代up>米<年代up>−1</年代up>)[<一个href="#B66">67年</一个>];[俄文(苯酚的)<年代ub>2</年代ub>L]<年代up>+ 4</年代up>(<年代vgheight="14.375" id="M75" style="vertical-align:-0.3135pt;width:58.325001px;" version="1.1" viewbox="0 0 58.325001 14.375" width="58.325001" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.375)">
<g transform="translate(72,-60.5)">
<text transform="matrix(1,0,0,-1,-71.95,60.86)">
<tspan style="font-size: 12.50px; " x="0" y="0">
2</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="6.2515001" y="0">
。</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="9.3772497" y="0">
5</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="18.404415" y="0">
×</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="29.182001" y="0">
1</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="35.433502" y="0">
0</gydF4y2Batspan>
</text>
<text transform="matrix(1,0,0,-1,-30.26,66.03)">
<tspan style="font-size: 8.75px; " x="0" y="0">
4</gydF4y2Batspan>
</text>
</g>
</g>
</svg>米<年代up>−1</年代up>)[<一个href="#B67">68年</一个>)(静电绑定模式);[俄文(tpy)(产后大出血<年代ub>3</年代ub>)<年代ub>2</年代ub>Cl)<年代up>+</年代up>(<年代vgheight="14.3625" id="M76" style="vertical-align:-3.2316pt;width:17.799999px;" version="1.1" viewbox="0 0 17.799999 14.3625" width="17.799999" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.3625)">
<g transform="translate(72,-60.51)">
<text transform="matrix(1,0,0,-1,-71.95,63.79)">
<tspan style="font-size: 12.50px; " x="0" y="0">
</gydF4y2Batspan>
</text>
<text transform="matrix(1,0,0,-1,-62.42,60.66)">
<tspan style="font-size: 8.75px; " x="0" y="0">
</gydF4y2Batspan>
</text>
</g>
</g>
</svg>=<年代vgheight="14.375" id="M77" style="vertical-align:-0.3135pt;width:58.325001px;" version="1.1" viewbox="0 0 58.325001 14.375" width="58.325001" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.375)">
<g transform="translate(72,-60.5)">
<text transform="matrix(1,0,0,-1,-71.95,60.86)">
<tspan style="font-size: 12.50px; " x="0" y="0">
4</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="6.2515001" y="0">
。</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="9.3772497" y="0">
1</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="18.404415" y="0">
×</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="29.182001" y="0">
1</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="35.433502" y="0">
0</gydF4y2Batspan>
</text>
<text transform="matrix(1,0,0,-1,-30.26,66.03)">
<tspan style="font-size: 8.75px; " x="0" y="0">
4</gydF4y2Batspan>
</text>
</g>
</g>
</svg>米<年代up>−1</年代up>,<gydF4y2Bai>年代</gydF4y2Bai>= 0.34)(<一个href="#B68">69年</一个>];[俄文(tpy)(沥青质<年代ub>3</年代ub>)Cl)<年代up>+</年代up>(<年代vgheight="14.3625" id="M78" style="vertical-align:-3.2316pt;width:17.799999px;" version="1.1" viewbox="0 0 17.799999 14.3625" width="17.799999" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.3625)">
<g transform="translate(72,-60.51)">
<text transform="matrix(1,0,0,-1,-71.95,63.79)">
<tspan style="font-size: 12.50px; " x="0" y="0">
</gydF4y2Batspan>
</text>
<text transform="matrix(1,0,0,-1,-62.42,60.66)">
<tspan style="font-size: 8.75px; " x="0" y="0">
</gydF4y2Batspan>
</text>
</g>
</g>
</svg>=<年代vgheight="14.375" id="M79" style="vertical-align:-0.3135pt;width:58.325001px;" version="1.1" viewbox="0 0 58.325001 14.375" width="58.325001" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.375)">
<g transform="translate(72,-60.5)">
<text transform="matrix(1,0,0,-1,-71.95,60.86)">
<tspan style="font-size: 12.50px; " x="0" y="0">
4</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="6.2515001" y="0">
。</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="9.3772497" y="0">
5</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="18.404415" y="0">
×</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="29.182001" y="0">
1</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="35.433502" y="0">
0</gydF4y2Batspan>
</text>
<text transform="matrix(1,0,0,-1,-30.26,66.03)">
<tspan style="font-size: 8.75px; " x="0" y="0">
4</gydF4y2Batspan>
</text>
</g>
</g>
</svg>米<年代up>−1</年代up>,<gydF4y2Bai>年代</gydF4y2Bai>= 0.1)(<一个href="#B68">69年</一个>];tricationic有限公司(III)和不对称的配体复合物,[有限公司(苯酚的)<年代ub>2</年代ub>(pdta)]<年代up>3 +</年代up>(<年代vgheight="14.3625" id="M80" style="vertical-align:-3.2316pt;width:17.799999px;" version="1.1" viewbox="0 0 17.799999 14.3625" width="17.799999" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.3625)">
<g transform="translate(72,-60.51)">
<text transform="matrix(1,0,0,-1,-71.95,63.79)">
<tspan style="font-size: 12.50px; " x="0" y="0">
</gydF4y2Batspan>
</text>
<text transform="matrix(1,0,0,-1,-62.42,60.66)">
<tspan style="font-size: 8.75px; " x="0" y="0">
</gydF4y2Batspan>
</text>
</g>
</g>
</svg>= 2.8×10<年代up>4</年代up>米<年代up>−1</年代up>)[<一个href="#B69">70年</一个>];[公司(bpy)<年代ub>2</年代ub>(CNOIP)]<年代up>3 +</年代up>(<年代vgheight="14.3625" id="M81" style="vertical-align:-3.2316pt;width:17.799999px;" version="1.1" viewbox="0 0 17.799999 14.3625" width="17.799999" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.3625)">
<g transform="translate(72,-60.51)">
<text transform="matrix(1,0,0,-1,-71.95,63.79)">
<tspan style="font-size: 12.50px; " x="0" y="0">
</gydF4y2Batspan>
</text>
<text transform="matrix(1,0,0,-1,-62.42,60.66)">
<tspan style="font-size: 8.75px; " x="0" y="0">
</gydF4y2Batspan>
</text>
</g>
</g>
</svg>= 5×10<年代up>4</年代up>米<年代up>−1</年代up>)[<一个href="#B70">71年</一个>]。</p><gydF4y2Bah5 id="sec3.6">3.6。伏安研究</gydF4y2Bah5>
<p>应用电化学方法研究metallointercalation和协调过渡金属配合物DNA提供了一个有用的补充以前使用的调查方法,如紫外可见光谱(<一个href="#B71">72年</一个>,<gydF4y2Ba一个href="#B72">73年</一个>]。</p><p>gydF4y2Ba复杂的电化学行为是众所周知的,强烈影响了电极材料。一个定义良好的观察和敏感峰从复杂的解决GC电极而不是工党。因此,一个GC电极用于这个调查。当CT-DNA添加到解决方案的复杂阳极和阴极峰电流高度复杂的以同样的方式减少日益增加的DNA,(图<一个href="//www.newsama.com/journals/bca/2012/126451/fig8/" target="_blank">8</一个>)。</p><gydF4y2Badiv class="floats-partial-section partial-carousel-wrapper" data-section="fig8">
<div class="floats-partial-content fig-content-fig8">
<div class="partial-carousel--single-image">
<img alt="" name="126451.fig.008" src="https://static-01.hindawi.com/articles/bca/volume-2012/126451/figures/126451.fig.008.jpg">
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<strong></strong>
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<div class="floats-partial-footer">
<div class="floats-partial-caption">
<span class="caption-text">图8</年代p一个n><一个一个ria-label="full view" class="caption-partial-url" href="//www.newsama.com/journals/bca/2012/126451/fig8/" title="" target="_blank"></a>
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<div class="floats-partial-caption-text">
<table></table>
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<p>大幅降低峰值电流的形成归因于慢慢扩散complex-DNA超分子复杂的由于免费药物的浓度(主要负责传输电流)降低(<一个href="#B73">74年</一个>]。</p><p>gydF4y2Ba峰电流逐渐衰减的复杂的DNA浓度增加,从20 - 100<年代vgheight="9.6750002" id="M82" style="vertical-align:-2.29482pt;width:9.6374998px;" version="1.1" viewbox="0 0 9.6374998 9.6750002" width="9.6374998" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,9.675)">
<g transform="translate(72,-64.26)">
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<tspan style="font-size: 12.50px; " x="0" y="0">
</gydF4y2Batspan>
</text>
</g>
</g>
</svg>米,可以用来量化的结合常数的应用下列方程(<一个href="#B74">75年</一个>]:<年代p一个nclass="equation" id="EEq6">
<svg height="38.575001" id="M83" preserveaspectratio="xMaxYMin" style="vertical-align:-0pt;width:700.9375px;" version="1.1" viewbox="0 0 700.9375 38.575001" width="700.9375" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,38.575)">
<g transform="translate(72,-41.14)">
<text transform="matrix(1,0,0,-1,103.26,53.45)">
<tspan style="font-size: 12.50px; " x="20.139999" y="7.3299999">
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<tspan style="font-size: 12.50px; " x="45.18" y="-7.25">
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<tspan style="font-size: 12.50px; " x="3.4758339" y="0">
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<tspan style="font-size: 12.50px; " x="9.727334" y="0">
g</gydF4y2Batspan>
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<tspan style="font-size: 12.50px; " x="31.02" y="0">
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<tspan style="font-size: 12.50px; " x="36.380001" y="-1.46">
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<tspan style="font-size: 12.50px; " x="123.13" y="-1.46">
</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="146.2" y="-16.040001">
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<tspan style="font-size: 12.50px; " x="4.1700001" y="-0.029999999">
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<tspan style="font-size: 12.50px; " x="13.197166" y="-0.029999999">
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一个</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="49.23" y="-8.79">
=</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="61.27039" y="-8.79">
l</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="64.746223" y="-8.79">
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g</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="79.324722" y="-8.79">
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<tspan style="font-size: 12.50px; " x="91.640175" y="-8.79">
+</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="102.9804" y="-8.79">
l</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="106.45623" y="-8.79">
o</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="112.70773" y="-8.79">
g</gydF4y2Batspan>
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<path d="m 267.67,56.57 32.13,0" style="fill:none;stroke:#000000;stroke-width:0.82499999;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:10;stroke-opacity:1;stroke-dasharray:none"></path>
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<text transform="matrix(1,0,0,-1,267.67,44.69)">
<tspan style="font-size: 12.50px; " x="0" y="0">
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<text transform="matrix(1,0,0,-1,273.67,41.57)">
<tspan style="font-size: 8.75px; " x="0" y="0">
0</gydF4y2Batspan>
</text>
<text transform="matrix(1,0,0,-1,281.33,44.69)">
<tspan style="font-size: 12.50px; " x="19.66" y="-1.4299999">
</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="0" y="0">
−</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="11.340221" y="0">
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<tspan style="font-size: 12.50px; " x="31.120001" y="-8.7600002">
,</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="192.78999" y="-8.7600002">
(</gydF4y2Batspan>
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)</gydF4y2Batspan>
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</svg></span>在哪里<gydF4y2Bai>K</gydF4y2Bai>绑定是常数,<年代vgheight="14.3875" id="M84" style="vertical-align:-3.25793pt;width:13.725px;" version="1.1" viewbox="0 0 13.725 14.3875" width="13.725" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.3875)">
<g transform="translate(72,-60.49)">
<text transform="matrix(1,0,0,-1,-71.95,63.79)">
<tspan style="font-size: 12.50px; " x="0" y="0">
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<text transform="matrix(1,0,0,-1,-65.95,60.66)">
<tspan style="font-size: 8.75px; " x="0" y="0">
0</gydF4y2Batspan>
</text>
</g>
</g>
</svg>和<gydF4y2Bai>我</gydF4y2Bai>是免费的客人的峰值电流和复杂,分别。</p><p>gydF4y2Ba结合常数,其值为3.81×10<年代up>4</年代up>摩尔<年代up>−1</年代up>L获得的拦截<年代vgheight="14.2" id="M85" style="vertical-align:-2.73372pt;width:91.849998px;" version="1.1" viewbox="0 0 91.849998 14.2" width="91.849998" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.2)">
<g transform="translate(72,-60.64)">
<text transform="matrix(1,0,0,-1,-71.95,63.41)">
<tspan style="font-size: 12.50px; " x="0" y="0">
l</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="3.4758339" y="0">
o</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="9.727334" y="0">
g</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="20.142332" y="0">
(</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="24.305832" y="0">
1</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="30.557331" y="0">
/</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="34.033165" y="0">
(</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="38.196667" y="0">
D</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="47.223831" y="0">
N</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="56.038445" y="0">
一个</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="65.065613" y="0">
]</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="69.229111" y="0">
)</gydF4y2Batspan>
</text>
</g>
</g>
</svg>与<年代vgheight="14.8625" id="M86" style="vertical-align:-3.25793pt;width:96.724998px;" version="1.1" viewbox="0 0 96.724998 14.8625" width="96.724998" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.8625)">
<g transform="translate(72,-60.11)">
<text transform="matrix(1,0,0,-1,-71.95,63.41)">
<tspan style="font-size: 12.50px; " x="0" y="0">
l</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="3.4758339" y="0">
o</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="9.727334" y="0">
g</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="20.142332" y="0">
(</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="24.305832" y="0">
</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="30.307272" y="0">
/</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="33.783108" y="0">
(</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="37.946606" y="0">
</gydF4y2Batspan>
</text>
<text transform="matrix(1,0,0,-1,-28,60.28)">
<tspan style="font-size: 8.75px; " x="0" y="0">
0</gydF4y2Batspan>
</text>
<text transform="matrix(1,0,0,-1,-20.34,63.41)">
<tspan style="font-size: 12.50px; " x="0" y="0">
−</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="11.327718" y="0">
</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="17.329159" y="0">
)</gydF4y2Batspan>
<tspan style="font-size: 12.50px; " x="21.492657" y="0">
)</gydF4y2Batspan>
</text>
</g>
</g>
</svg>图(图<一个href="//www.newsama.com/journals/bca/2012/126451/fig9/" target="_blank">9</一个>)。</p><gydF4y2Badiv class="floats-partial-section partial-carousel-wrapper" data-section="fig9">
<div class="floats-partial-content fig-content-fig9">
<div class="partial-carousel--single-image">
<img alt="" name="126451.fig.009" src="https://static-01.hindawi.com/articles/bca/volume-2012/126451/figures/126451.fig.009.jpg">
<br>
<strong></strong>
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<div class="floats-partial-footer">
<div class="floats-partial-caption">
<span class="caption-text">图9</年代p一个n><一个一个ria-label="full view" class="caption-partial-url" href="//www.newsama.com/journals/bca/2012/126451/fig9/" title="" target="_blank"></a>
</div>
<div class="floats-partial-caption-text">
<sup>−1</年代up>
<table>
循环voltammogram 0.1毫米铁(III)复杂的抛光玻璃碳电极在不同浓度的缺失和存在的DNA。v: 100 mVsgydF4y2Ba缓冲区:0.05 Tris-HCl缓冲区(pH值7.4)。</gydF4y2Batable>
</div>
</div>
</div>
<p>绑定常量的值从紫外吸收、荧光光谱和简历的测量,9×10<年代up>4</年代up>,3.54×10<年代up>4</年代up>和3.81×10<年代up>4</年代up>摩尔<年代up>−1</年代up>L,分别在协议。</p><p>gydF4y2Ba从上述实验的结果,形成复杂的DNA的电化学一般复杂导致的减少自由反应溶液浓度的复杂,造成峰值电流的减少。</p><gydF4y2Bah4 id="conclusion">4所示。结论</gydF4y2Bah4>
<p>药理研究的最重要目标之一就是寻找新的分子结构,具有有效的抗肿瘤活性。这推动了无机和有机金属化学寻找新的金属化合物具有良好的活动,最好是针对肿瘤负责癌症死亡率。在这项研究中,绑定交互的水溶性席夫碱的铁(III)复杂,科幻小说,科幻小说1/4 N, N<年代ub>0</年代ub>bis{5 -[(氯化triphenylphosphonium)甲基]salicylidene} -o-phenylenediamine)与小牛胸腺DNA被调查,结果表明,复杂的可以通过槽与DNA结合绑定模式。</p><gydF4y2Bah4 id="acknowledgment">承认</gydF4y2Bah4>
<p>作者感谢Razi大学研究中心的金融支持伊朗。</p></gydF4y2Badiv>
<div class="xml-content">
<h4 class="references" id="references">引用</gydF4y2Bah4>
<ol>
<li id="B1">答:a . a . Abu-Hussen”合成和光谱研究三元bis-Schiff-base复合物氧和/或氮捐助者,”<gydF4y2Bai>《配位化学</gydF4y2Bai>卷,59号2、157 - 176年,2006页。<年代p一个nclass="reflinks">视图:<一个href="https://doi.org/10.1080/00958970500266230">出版商的网站</一个><年代p一个nclass="sep">|</年代p一个n><一个href="https://scholar.google.com/scholar_lookup?title=Synthesis%20and%20spectroscopic%20studies%20on%20ternary%20bis-Schiff-base%20complexes%20having%20oxygen%20and/or%20nitrogen%20donors&author=A. A. A. Abu-Hussen&publication_year=2006" target="_blank">谷歌学术搜索</一个></年代p一个n></li>
<li id="B2">m . s . Karthikeyan d·j·普拉萨德,b . Poojary k Subrahmanya Bhat, b . s .大声叫,和n s Kumari”合成和生物活性的希夫曼尼希碱轴承2,4-dichloro-5-fluorophenyl一半,”<gydF4y2Bai>生物有机和药物化学</gydF4y2Bai>,14卷,不。22日,第7489 - 7482页,2006年。<年代p一个nclass="reflinks">视图:<一个href="https://doi.org/10.1016/j.bmc.2006.07.015">出版商的网站</一个><年代p一个nclass="sep">|</年代p一个n><一个href="https://scholar.google.com/scholar_lookup?title=Synthesis%20and%20biological%20activity%20of%20Schiff%20and%20Mannich%20bases%20bearing%202,4-dichloro-5-fluorophenyl%20moiety&author=M. S. Karthikeyan&author=D. J. Prasad&author=B. Poojary&author=K. Subrahmanya Bhat&author=B. S. Holla&author=&author=N. S. Kumari&publication_year=2006" target="_blank">谷歌学术搜索</一个></年代p一个n></li>
<li id="B3">辛格k、m . s .瓦和p . Tyagi”的合成、表征和生物研究有限公司(II)、镍(II)、铜(II)和锌(II)配合物的双齿希夫碱基派生杂环酮,”<gydF4y2Bai>欧洲药物化学杂志》上</gydF4y2Bai>第41卷。。1,第153 - 147页,2006。<年代p一个nclass="reflinks">视图:<一个href="https://doi.org/10.1016/j.ejmech.2005.06.006">出版商的网站</一个><年代p一个nclass="sep">|</年代p一个n><一个href="https://scholar.google.com/scholar_lookup?title=Synthesis,%20characterization%20and%20biological%20studies%20of%20Co(II),%20Ni(II),%20Cu(II)%20and%20Zn(II)%20complexes%20with%20bidentate%20Schiff%20bases%20derived%20by%20heterocyclic%20ketone&author=K. Singh&author=M. S. Barwa&author=&author=P. Tyagi&publication_year=2006" target="_blank">谷歌学术搜索</一个></年代p一个n></li>
<li id="B4">p . Panneerselvam r . r . Nair g . Vijayalakshmi e·h·萨勃拉曼尼亚和s . k . bloom”希夫碱的合成4 - (4-aminophenyl)吗啉作为潜在的抗菌药物,”<gydF4y2Bai>欧洲药物化学杂志》上</gydF4y2Bai>,40卷,不。2、225 - 229年,2005页。<年代p一个nclass="reflinks">视图:<一个href="https://doi.org/10.1016/j.ejmech.2004.09.003">出版商的网站</一个><年代p一个nclass="sep">|</年代p一个n><一个href="https://scholar.google.com/scholar_lookup?title=Synthesis%20of%20Schiff%20bases%20of%204-(4-aminophenyl)-morpholine%20as%20potential%20antimicrobial%20agents&author=P. Panneerselvam&author=R. R. Nair&author=G. Vijayalakshmi&author=E. H. Subramanian&author=&author=S. K. Sridhar&publication_year=2005" target="_blank">谷歌学术搜索</一个></年代p一个n></li>
<li id="B5">s . k . bloom, m·萨拉瓦南和a·拉梅什”合成和抗菌筛选腙希夫和靛红衍生物的曼尼希碱,”<gydF4y2Bai>欧洲药物化学杂志》上</gydF4y2Bai>,36卷,不。7 - 8,615 - 625年,2001页。<年代p一个nclass="reflinks">视图:<一个href="https://doi.org/10.1016/S0223-5234(01)01255-7">出版商的网站</一个><年代p一个nclass="sep">|</年代p一个n><一个href="https://scholar.google.com/scholar_lookup?title=Synthesis%20and%20antibacterial%20screening%20of%20hydrazones,%20Schiff%20and%20Mannich%20bases%20of%20isatin%20derivatives&author=S. K. Sridhar&author=M. Saravanan&author=&author=A. Ramesh&publication_year=2001" target="_blank">谷歌学术搜索</一个></年代p一个n></li>
<li id="B6">s . n . Pandeya d·g·纳和Declercq大肠”,合成、抗菌、抗真菌和抗艾滋病活动希夫曼尼希碱来源于靛红衍生物和<gydF4y2Bai>N</gydF4y2Bai>- [4 - (4′-chlorophenyl) thiazol-2-yl]氨基硫脲,”<gydF4y2Bai>欧洲制药科学杂志》上</gydF4y2Bai>,9卷,不。1,25-31,1999页。<年代p一个nclass="reflinks">视图:<一个href="https://doi.org/10.1016/S0928-0987(99)00038-X">出版商的网站</一个><年代p一个nclass="sep">|</年代p一个n><一个href="https://scholar.google.com/scholar_lookup?title=Synthesis,%20antibacterial,%20antifungal%20and%20anti-HIV%20activities%20of%20Schiff%20and%20Mannich%20bases%20derived%20from%20isatin%20derivatives%20and%20N-[4-(4′
-chlorophenyl)thiazol-2-yl]%20thiosemicarbazide&author=S. N. Pandeya&author=D. Sriram&author=G. Nath&author=&author=E. Declercq&publication_year=1999" target="_blank">谷歌学术搜索</一个></年代p一个n></li>
<li id="B7">r . Mladenova m . Ignatova n . Manolova t .佩特洛娃和i Rashkov席夫碱化合物的制备、表征及生物活性来源于8-hydroxyquinoline-2-carboxaldehyde Jeffamines ED<年代up>®</年代up>”,<gydF4y2Bai>欧洲聚合物杂志》</gydF4y2Bai>,38卷,不。5,989 - 999年,2002页。<年代p一个nclass="reflinks">视图:<一个href="https://doi.org/10.1016/S0014-3057(01)00260-9">出版商的网站</一个><年代p一个nclass="sep">|</年代p一个n><一个href="https://scholar.google.com/scholar_lookup?title=Preparation,%20characterization%20and%20biological%20activity%20of%20Schiff%20base%20compounds%20derived%20from%208-hydroxyquinoline-2-carboxaldehyde%20and%20Jeffamines%20ED®&author=R. Mladenova&author=M. Ignatova&author=N. Manolova&author=T. Petrova&author=&author=I. Rashkov&publication_year=2002" target="_blank">谷歌学术搜索</一个></年代p一个n></li>
<li id="B8">o·m·沃尔什·m·j . Meegan和t . Al Nakib r·m·普伦德加斯特”的合成3-acetoxyazetidin-2-ones和3-hydroxyazetidin-2-ones抗真菌和抗菌活性,”<gydF4y2Bai>欧洲药物化学杂志》上</gydF4y2Bai>没有,卷。31日。12日,第1000 - 989页,1996年。<年代p一个nclass="reflinks">视图:<一个href="https://doi.org/10.1016/S0223-5234(97)86178-8">出版商的网站</一个><年代p一个nclass="sep">|</年代p一个n><一个href="https://scholar.google.com/scholar_lookup?title=Synthesis%20of%203-acetoxyazetidin-2-ones%20and%203-hydroxyazetidin-2-ones%20with%20antifungal%20and%20antibacterial%20activity&author=O. M. Walsh&author=M. J. Meegan&author=R. M. Prendergast&author=&author=T. Al Nakib&publication_year=1996" target="_blank">谷歌学术搜索</一个></年代p一个n></li>
<li id="B9">z Travniček m .偏头痛,zŠindelařet al .,“准备、理化性质和生物活性的铜(II)配合物6 - (2-chlorobenzylamino)嘌呤(霍奇金淋巴瘤<年代ub>1</年代ub>()或6)- 3-chlorobenzylamino嘌呤(霍奇金淋巴瘤<年代ub>2</年代ub>)。(铜单晶x射线结构(H<年代up>+</年代up>l<年代ub>2</年代ub>)<年代ub>2</年代ub>Cl<年代ub>3</年代ub>]Cl<gydF4y2Bai>·</gydF4y2Bai>2 h<年代ub>2</年代ub>啊,”<gydF4y2Bai>无机生物化学杂志》上</gydF4y2Bai>,卷84,不。1 - 2,23-32,2001页。<年代p一个nclass="reflinks">视图:<一个href="https://doi.org/10.1016/S0162-0134(00)00218-X">出版商的网站</一个><年代p一个nclass="sep">|</年代p一个n><一个href="https://scholar.google.com/scholar_lookup?title=Preparation,%20physicochemical%20properties%20and%20biological%20activity%20of%20copper(II)%20complexes%20with%206-(2-chlorobenzylamino)purine%20(HL1)%20or%206-(3-chlorobenzylamino)purine%20(HL2).%20The%20single-crystal%20X-ray%20structure%20of%20[Cu(H+L2)2Cl3]Cl·2H2O&author=Z. Trávníček&author=M. Malo&author=Z. Šindelář et al.&publication_year=2001" target="_blank">谷歌学术搜索</一个></年代p一个n></li>
<li id="B10">El-Ayaan和a·a·m·阿卜杜勒•阿齐兹”合成、抗菌活性和分子建模包含笨重的钴和镍配合物的配体:<gydF4y2Bai>国际清算银行</gydF4y2Bai>(<gydF4y2Bai>N</gydF4y2Bai>- (2,6-diisopropylphenyl)亚氨基的苊,”<gydF4y2Bai>欧洲药物化学杂志》上</gydF4y2Bai>,40卷,不。12日,第1221 - 1214页,2005年。<年代p一个nclass="reflinks">视图:<一个href="https://doi.org/10.1016/j.ejmech.2005.06.009">出版商的网站</一个><年代p一个nclass="sep">|</年代p一个n><一个href="https://scholar.google.com/scholar_lookup?title=Synthesis,%20antimicrobial%20activity%20and%20molecular%20modeling%20of%20cobalt%20and%20nickel%20complexes%20containing%20the%20bulky%20ligand:%20bis[N-(2,6-diisopropylphenyl)%20imino]%20acenaphthene&author=U. El-Ayaan &author=A. A. M. Abdel-Aziz&publication_year=2005" target="_blank">谷歌学术搜索</一个></年代p一个n></li>
<li id="B11">m·桑麦资柏柏尔语,和e . Akbaş”合成、抗菌和抗真菌活性的一些新的pyridazinone金属配合物,”<gydF4y2Bai>欧洲药物化学杂志》上</gydF4y2Bai>第41卷。。1,第105 - 101页,2006。<年代p一个nclass="reflinks">视图:<一个href="https://doi.org/10.1016/j.ejmech.2005.10.003">出版商的网站</一个><年代p一个nclass="sep">|</年代p一个n><一个href="https://scholar.google.com/scholar_lookup?title=Synthesis,%20antibacterial%20and%20antifungal%20activity%20of%20some%20new%20pyridazinone%20metal%20complexes&author=M. Sönmez&author=I. Berber&author=&author=E. Akbaş&publication_year=2006" target="_blank">谷歌学术搜索</一个></年代p一个n></li>
<li id="B12">e . Keskioǧlu a . b . Gunduzalp一群獾,f . Hamurcu和b Erk,“铬(III)、铁(III)和(3)复合物的四齿席夫碱配体(应该):合成、表征、性质和生物活性,”<gydF4y2Bai>Spectrochimica Acta-Part一</gydF4y2Bai>,卷70,不。3、634 - 640年,2008页。<年代p一个nclass="reflinks">视图:<一个href="https://doi.org/10.1016/j.saa.2007.08.011">出版商的网站</一个><年代p一个nclass="sep">|</年代p一个n><一个href="https://scholar.google.com/scholar_lookup?title=Cr(III),%20Fe(III)%20and%20Co(III)%20complexes%20of%20tetradentate%20(ONNO)%20Schiff%20base%20ligands:%20synthesis,%20characterization,%20properties%20and%20biological%20activity&author=E. Keskioǧlu&author=A. B. Gündüzalp&author=S. Çete&author=F. Hamurcu&author=&author=B. Erk&publication_year=2008" target="_blank">谷歌学术搜索</一个></年代p一个n></li>
<li id="B13">J.-Z。吴和l .元,“合成与DNA相互作用的研究与2双核钌(II)络合物,9-bis (2-imidazo [4, 5 -<gydF4y2Bai>f</gydF4y2Bai>][1,10]邻二氮杂菲)1,10-phenanthroline为桥接和插层配体”,<gydF4y2Bai>无机生物化学杂志》上</gydF4y2Bai>,卷98,不。1,41 - 45页,2004。<年代p一个nclass="reflinks">视图:<一个href="https://doi.org/10.1016/j.jinorgbio.2003.08.011">出版商的网站</一个><年代p一个nclass="sep">|</年代p一个n><一个href="https://scholar.google.com/scholar_lookup?title=Synthesis%20and%20DNA%20interaction%20studies%20of%20a%20binuclear%20ruthenium(II)%20complex%20with%202,9-bis(2-imidazo[4,5-f][1,10]phenanthroline)-1,10-phenanthroline%20as%20bridging%20and%20intercalating%20ligand&author=J.-Z. Wu &author=L. Yuan&publication_year=2004" target="_blank">谷歌学术搜索</一个></年代p一个n></li>
<li id="B14">Balasubramanian k p, k . Parameswari诉Chinnusamy, r·普拉巴卡兰和k . Natarajan”合成、表征、电子化学、催化和生物活性的钌(III)复合物和双齿N, O / S捐赠者配体,“<gydF4y2Bai>Spectrochimica Acta-Part一</gydF4y2Bai>,卷65,不。3 - 4、678 - 683年,2006页。<年代p一个nclass="reflinks">视图:<一个href="https://doi.org/10.1016/j.saa.2005.12.029">出版商的网站</一个><年代p一个nclass="sep">|</年代p一个n><一个href="https://scholar.google.com/scholar_lookup?title=Synthesis,%20characterization,%20electro%20chemistry,%20catalytic%20and%20biological%20activities%20of%20ruthenium(III)%20complexes%20with%20bidentate%20N,%20O/S%20donor%20ligands&author=K. P. Balasubramanian&author=K. Parameswari&author=V. Chinnusamy&author=R. Prabhakaran&author=&author=K. Natarajan&publication_year=2006" target="_blank">谷歌学术搜索</一个></年代p一个n></li>
<li id="B15">山田,“进步金属席夫碱配合物的立体化学方面,“<gydF4y2Bai>配位化学的评论</gydF4y2Bai>卷,190 - 192,537 - 555年,1999页。<年代p一个nclass="reflinks">视图:<一个href="https://doi.org/10.1016/S0010-8545(99)00099-5">出版商的网站</一个><年代p一个nclass="sep">|</年代p一个n><一个href="https://scholar.google.com/scholar_lookup?title=Advancement%20in%20stereochemical%20aspects%20of%20Schiff%20base%20metal%20complexes&author=S. Yamada&publication_year=1999" target="_blank">谷歌学术搜索</一个></年代p一个n></li>
<li id="B16">a . Bottcher t . Takeuchi k . i Hardcastle et al .,“光谱和电化学(III)席夫碱钴配合物,”<gydF4y2Bai>无机化学</gydF4y2Bai>,36卷,不。12日,第2504 - 2498页,1997年。<年代p一个nclass="reflinks">视图:<一个href="https://scholar.google.com/scholar_lookup?title=Spectroscopy%20and%20electrochemistry%20of%20cobalt(III)%20schiff%20base%20complexes&author=A. Böttcher&author=T. Takeuchi&author=K. I. Hardcastle et al.&publication_year=1997" target="_blank">谷歌学术搜索</一个></年代p一个n></li>
<li id="B17">大肠Canpolat和m .岩石”,研究单核螯合物来自代替席夫碱配体(第2部分):合成和表征的新5-bromosalicyliden -<gydF4y2Bai>p</gydF4y2Bai>-aminoacetophenoneoxime和Co (II)及其复合物,镍(II)、铜(II)和锌(II),“<gydF4y2Bai>《配位化学</gydF4y2Bai>卷,57号14日,第1223 - 1217页,2004年。<年代p一个nclass="reflinks">视图:<一个href="https://doi.org/10.1080/00958970412331285913">出版商的网站</一个><年代p一个nclass="sep">|</年代p一个n><一个href="https://scholar.google.com/scholar_lookup?title=Studies%20on%20mononuclear%20chelates%20derived%20from%20substituted%20Schiff-base%20ligands%20(part%202):%20synthesis%20and%20characterization%20of%20a%20new%205-bromosalicyliden-p-aminoacetophenoneoxime%20and%20its%20complexes%20with%20Co(II),%20Ni(II),%20Cu(II)%20and%20Zn(II)&author=E. Canpolat &author=M. Kaya&publication_year=2004" target="_blank">谷歌学术搜索</一个></年代p一个n></li>
<li id="B18">r·l·卢卡斯,m . k . Zart j . Murkerjee t·n·索雷尔d·r·鲍威尔和A . s . Borovik“模块化方法向调节金属离子的辅助协调球体:微分双氧活化分子内氢键的帮助下,“<gydF4y2Bai>美国化学学会杂志》上</gydF4y2Bai>,卷128,不。48岁,15476 - 15489年,2006页。<年代p一个nclass="reflinks">视图:<一个href="https://doi.org/10.1021/ja063935+">出版商的网站</一个><年代p一个nclass="sep">|</年代p一个n><一个href="https://scholar.google.com/scholar_lookup?title=A%20modular%20approach%20toward%20regulating%20the%20secondary%20coordination%20sphere%20of%20metal%20ions:%20differential%20dioxygen%20activation%20assisted%20by%20intramolecular%20hydrogen%20bonds&author=R. L. Lucas&author=M. K. Zart&author=J. Murkerjee&author=T. N. Sorrell&author=D. R. Powell&author=&author=A. S. Borovik&publication_year=2006" target="_blank">谷歌学术搜索</一个></年代p一个n></li>
<li id="B19">p . e . Aranha m·p·多斯桑托斯s Romera和e . r . Dockal”合成、表征和四齿席夫碱的光谱研究铬(III)复合物,”<gydF4y2Bai>多面体</gydF4y2Bai>,26卷,不。7,1373 - 1382年,2007页。<年代p一个nclass="reflinks">视图:<一个href="https://doi.org/10.1016/j.poly.2006.11.005">出版商的网站</一个><年代p一个nclass="sep">|</年代p一个n><一个href="https://scholar.google.com/scholar_lookup?title=Synthesis,%20characterization,%20and%20spectroscopic%20studies%20of%20tetradentate%20Schiff%20base%20chromium(III)%20complexes&author=P. E. Aranha&author=M. P. dos Santos&author=S. Romera&author=&author=E. R. Dockal&publication_year=2007" target="_blank">谷歌学术搜索</一个></年代p一个n></li>
<li id="B20">a·a·苏莱曼和w·Linert“结构性特征ONS-donor salicylidene<gydF4y2Bai>希夫</gydF4y2Bai>基复合物”,<gydF4y2Bai>Monatshefte毛皮化学</gydF4y2Bai>,卷138,不。3、175 - 189年,2007页。<年代p一个nclass="reflinks">视图:<一个href="https://doi.org/10.1007/s00706-007-0585-6">出版商的网站</一个><年代p一个nclass="sep">|</年代p一个n><一个href="https://scholar.google.com/scholar_lookup?title=Structural%20features%20of%20ONS-donor%20salicylidene%20Schiff%20base%20complexes&author=A. A. Soliman &author=W. Linert&publication_year=2007" target="_blank">谷歌学术搜索</一个></年代p一个n></li>
<li id="B21">w·m·谢g .徐l . Li Liu y妞妞,和美国,“体内的活动样活性<gydF4y2Bai>N, N</gydF4y2Bai>1,3-propyl-bis (salicyladimine)] oxovanadium (IV),“<gydF4y2Bai>欧洲药物化学杂志》上</gydF4y2Bai>,42卷,不。6,817 - 822年,2007页。<年代p一个nclass="reflinks">视图:<一个href="https://doi.org/10.1016/j.ejmech.2006.12.021">出版商的网站</一个><年代p一个nclass="sep">|</年代p一个n><一个href="https://scholar.google.com/scholar_lookup?title=In%20vivo%20insulin-mimetic%20activity%20of%20[N,N-1,3-propyl-bis(salicyladimine)]oxovanadium(IV)&author=M. Xie&author=G. Xu&author=L. Li&author=W. Liu&author=Y. Niu&author=&author=S. Yan&publication_year=2007" target="_blank">谷歌学术搜索</一个></年代p一个n></li>
<li id="B22">诉Milacic, d . Chen l . Ronconi k . r . Landis-Piwowar d . Fregona问:p .窦,“一种新型抗癌黄金(III)二硫代氨基甲酸化合物可以抑制一种纯化20 s蛋白酶体和26 s蛋白酶体在人类乳腺癌细胞培养和异种移植,”<gydF4y2Bai>癌症研究</gydF4y2Bai>,卷66,不。21日,第10486 - 10478页,2006年。<年代p一个nclass="reflinks">视图:<一个href="https://doi.org/10.1158/0008-5472.CAN-06-3017">出版商的网站</一个><年代p一个nclass="sep">|</年代p一个n><一个href="https://scholar.google.com/scholar_lookup?title=A%20novel%20anticancer%20gold(III)%20dithiocarbamate%20compound%20inhibits%20the%20activity%20of%20a%20purified%2020S%20proteasome%20and%2026S%20proteasome%20in%20human%20breast%20cancer%20cell%20cultures%20and%20xenografts&author=V. Milacic&author=D. Chen&author=L. Ronconi&author=K. R. Landis-Piwowar&author=D. Fregona&author=&author=Q. P. Dou&publication_year=2006" target="_blank">谷歌学术搜索</一个></年代p一个n></li>
<li id="B23">Kostova,“黄金协调配合物作为抗癌药物,”<gydF4y2Bai>在药物化学抗癌药物</gydF4y2Bai>》第六卷,没有。1,19-32,2006页。<年代p一个nclass="reflinks">视图:<一个href="https://doi.org/10.2174/187152006774755500">出版商的网站</一个><年代p一个nclass="sep">|</年代p一个n><一个href="https://scholar.google.com/scholar_lookup?title=Gold%20coordination%20complexes%20as%20anticancer%20agents&author=I. Kostova&publication_year=2006" target="_blank">谷歌学术搜索</一个></年代p一个n></li>
<li id="B24">f . Li w·陈,c . Tang和美国,“最近发展过渡金属配合物与DNA相互作用的生物传感器及其应用的基础上,“<gydF4y2Bai>Talanta</gydF4y2Bai>,卷77,不。1,1 - 8,2008页。<年代p一个nclass="reflinks">视图:<一个href="https://doi.org/10.1016/j.talanta.2008.06.011">出版商的网站</一个><年代p一个nclass="sep">|</年代p一个n><一个href="https://scholar.google.com/scholar_lookup?title=Recent%20development%20of%20interaction%20of%20transition%20metal%20complexes%20with%20DNA%20based%20on%20biosensor%20and%20its%20applications&author=F. Li&author=W. Chen&author=C. Tang&author=&author=S. Zhang&publication_year=2008" target="_blank">谷歌学术搜索</一个></年代p一个n></li>
<li id="B25">r . a . Sanchez-Delgado a Anzellotti, l·苏亚雷斯“金属配合物作为化疗药物对热带疾病:疟疾、利什曼病和锥虫病,”<gydF4y2Bai>金属离子在生物系统</gydF4y2Bai>h . Sigel和a . Sigel Eds。,pp。379- - - - - -419,Marcel Dekker, New York, Ny, USA, 2004.<年代p一个nclass="reflinks">视图:<一个href="https://scholar.google.com/scholar_lookup?title=Metal%20complexes%20as%20chemotherapeutic%20agents%20against%20tropical%20diseases:%20malaria,%20leishmaniasis%20and%20trypanosomiasis&author=R. A. Sanchez-Delgado&author=A. Anzellotti&author=&author=L. Suarez&publication_year=2004" target="_blank">谷歌学术搜索</一个></年代p一个n></li>
<li id="B26">贝尔蒂尼,h·b·格雷,依施蒂费尔,<gydF4y2Bai>生物无机化学:结构和反应性</gydF4y2Bai>美国加州大学科学书籍,索萨利托,2007。<年代p一个nclass="reflinks"></span></li>
<li id="B27">Tidwell r r和d·w·柏金“Dicationic DNA小沟绑定作为抗菌药物,”<gydF4y2Bai>从小分子DNA和RNA绑定到拖</gydF4y2Bai>m . Demeunynck, c·贝利和w·d·威尔逊,Eds。,2003年Wiley-VCH。<年代p一个nclass="reflinks">视图:<一个href="https://scholar.google.com/scholar_lookup?title=Dicationic%20DNA%20minor%20groove%20binders%20as%20antimicrobial%20agents&author=R. R. Tidwell &author=D. W. Boykin&publication_year=2003" target="_blank">谷歌学术搜索</一个></年代p一个n></li>
<li id="B28a">a . k .智利的m . Nethaji查克推瓦蒂和a . r .,“合成、晶体结构、DNA结合和photo-induced DNA裂解活性(<gydF4y2Bai>年代</gydF4y2Bai>甲基-<年代ub>l</年代ub>半胱氨酸)铜(II)配合物杂环的基地,“<gydF4y2Bai>无机生物化学杂志》上</gydF4y2Bai>,卷101,不。2、233 - 244年,2007页。<年代p一个nclass="reflinks">视图:<一个href="https://doi.org/10.1016/j.jinorgbio.2006.09.018">出版商的网站</一个><年代p一个nclass="sep">|</年代p一个n><一个href="https://scholar.google.com/scholar_lookup?title=Synthesis,%20crystal%20structure,%20DNA%20binding%20and%20photo-induced%20DNA%20cleavage%20activity%20of%20(S-methyl-L-cysteine)copper(II)%20complexes%20of%20heterocyclic%20bases&author=A. K. Patra&author=M. Nethaji&author=&author=A. R. Chakravarty&publication_year=2007" target="_blank">谷歌学术搜索</一个></年代p一个n></li>
<li id="B28b">a . k .智利的t . Bhowmick罗伊,s . Ramakumar查克推瓦蒂和a . r .,“铜(II)配合物精氨酸作为netropsin模拟显示红灯,DNA分裂活动”<gydF4y2Bai>无机化学</gydF4y2Bai>,48卷,不。7,2932 - 2943年,2009页。<年代p一个nclass="reflinks">视图:<一个href="https://doi.org/10.1021/ic8017425">出版商的网站</一个><年代p一个nclass="sep">|</年代p一个n><一个href="https://scholar.google.com/scholar_lookup?title=Copper(II)%20complexes%20of%20L-arginine%20as%20netropsin%20mimics%20showing%20DNA%20cleavage%20activity%20in%20red%20light&author=A. K. Patra&author=T. Bhowmick&author=S. Roy&author=S. Ramakumar&author=&author=A. R. Chakravarty&publication_year=2009" target="_blank">谷歌学术搜索</一个></年代p一个n></li>
<li id="B29">Ramakrishnan,诉Rajendiran m . Palaniandavar et al .,“诱导细胞死亡的三元铜(II)配合物酪氨酸和二亚胺:coligands DNA结合和乳沟的作用和抗癌活动,“<gydF4y2Bai>无机化学</gydF4y2Bai>,48卷,不。4、1309 - 1322年,2009页。<年代p一个nclass="reflinks">视图:<一个href="https://doi.org/10.1021/ic801144x">出版商的网站</一个><年代p一个nclass="sep">|</年代p一个n><一个href="https://scholar.google.com/scholar_lookup?title=Induction%20of%20cell%20death%20by%20ternary%20copper(II)%20complexes%20of%20l-tyrosine%20and%20diimines:%20role%20of%20coligands%20on%20DNA%20binding%20and%20cleavage%20and%20anticancer%20activity&author=S. Ramakrishnan&author=V. Rajendiran&author=M. Palaniandavar et al.&publication_year=2009" target="_blank">谷歌学术搜索</一个></年代p一个n></li>
<li id="B30">d·b·霍尔,r . e . Holmlin, j·k·巴顿,“通过远程电子转移DNA氧化损伤,”<gydF4y2Bai>自然</gydF4y2Bai>,卷382,不。6593年,第735 - 731页,1996年。<年代p一个nclass="reflinks">视图:<一个href="https://doi.org/10.1038/382731a0">出版商的网站</一个><年代p一个nclass="sep">|</年代p一个n><一个href="https://scholar.google.com/scholar_lookup?title=Oxidative%20DNA%20damage%20through%20long-range%20electron%20transfer&author=D. B. Hall&author=R. E. Holmlin&author=&author=J. K. Barton&publication_year=1996" target="_blank">谷歌学术搜索</一个></年代p一个n></li>
<li id="B31">k . e . Erkkila d·t·奥多姆和j·k·巴顿,“识别和反应的metallointercalators DNA,”<gydF4y2Bai>化学评论</gydF4y2Bai>,卷99,不。9日,第2795 - 2777页,1999年。<年代p一个nclass="reflinks">视图:<一个href="https://scholar.google.com/scholar_lookup?title=Recognition%20and%20reaction%20of%20metallointercalators%20with%20DNA&author=K. E. Erkkila&author=D. T. Odom&author=&author=J. K. Barton&publication_year=1999" target="_blank">谷歌学术搜索</一个></年代p一个n></li>
<li id="B32">b . Lippert,”碱基金属离子结合模式的多样性,”<gydF4y2Bai>配位化学的评论</gydF4y2Bai>卷,200 - 202,487 - 516年,2000页。<年代p一个nclass="reflinks">视图:<一个href="https://doi.org/10.1016/S0010-8545(00)00260-5">出版商的网站</一个><年代p一个nclass="sep">|</年代p一个n><一个href="https://scholar.google.com/scholar_lookup?title=Multiplicity%20of%20metal%20ion%20binding%20patterns%20to%20nucleobases&author=B. Lippert&publication_year=2000" target="_blank">谷歌学术搜索</一个></年代p一个n></li>
<li id="B33">m . c . Liu, t·张,h .太阳,“DNA水解得到di multi-nuclear金属配合物,”<gydF4y2Bai>配位化学的评论</gydF4y2Bai>,卷248,不。1 - 2、147 - 168年,2004页。<年代p一个nclass="reflinks">视图:<一个href="https://doi.org/10.1016/j.cct.2003.11.002">出版商的网站</一个><年代p一个nclass="sep">|</年代p一个n><一个href="https://scholar.google.com/scholar_lookup?title=DNA%20hydrolysis%20promoted%20by%20di-%20and%20multi-nuclear%20metal%20complexes&author=C. Liu&author=M. Wang&author=T. Zhang&author=&author=H. Sun&publication_year=2004" target="_blank">谷歌学术搜索</一个></年代p一个n></li>
<li id="B34">g . Pratviel j . Bernadou、莫尼耶b,“由金属配合物DNA和RNA的乳沟,”<gydF4y2Bai>无机化学的发展</gydF4y2Bai>,45卷,第312 - 251页,1998年。<年代p一个nclass="reflinks">视图:<一个href="https://doi.org/10.1016/S0898-8838(08)60027-6">出版商的网站</一个><年代p一个nclass="sep">|</年代p一个n><一个href="https://scholar.google.com/scholar_lookup?title=DNA%20and%20RNA%20cleavage%20by%20metal%20complexes&author=G. Pratviel&author=J. Bernadou&author=&author=B. Meunier&publication_year=1998" target="_blank">谷歌学术搜索</一个></年代p一个n></li>
<li id="B35">池田m . Shionoya t . e .木村和m . Shiro,“小说”多点”的碱基分子识别的新锌(II)复杂acridine-pendant cyclen (cyclen = 1, 4, 7, 10-tetraazacyclododecane),“<gydF4y2Bai>美国化学学会杂志》上</gydF4y2Bai>,卷116,不。9日,第3859 - 3848页,1994年。<年代p一个nclass="reflinks">视图:<一个href="https://doi.org/10.1021/ja00088a021">出版商的网站</一个><年代p一个nclass="sep">|</年代p一个n><一个href="https://scholar.google.com/scholar_lookup?title=Novel%20“multipoint”%20molecular%20recognition%20of%20nucleobases%20by%20a%20new%20zinc(II)%20complex%20of%20acridine-pendant%20cyclen(cyclen%20=%201,4,7,10-tetraazacyclododecane)&author=M. Shionoya&author=T. Ikeda&author=E. Kimura&author=&author=M. Shiro&publication_year=1994" target="_blank">谷歌学术搜索</一个></年代p一个n></li>
<li id="B36">d·m·爱泼斯坦l . l . Chappell h·哈利利的r . m . Supkowski w·w·德Horrocks和j·r·莫罗,”欧盟(III)大环配合物促进解理和绑定到模型的5′mRNA的帽子。悬而未决的组和第二金属离子的影响,“<gydF4y2Bai>无机化学</gydF4y2Bai>,39卷,不。10日,2130 - 2134年,2000页。<年代p一个nclass="reflinks">视图:<一个href="https://doi.org/10.1021/ic9912068">出版商的网站</一个><年代p一个nclass="sep">|</年代p一个n><一个href="https://scholar.google.com/scholar_lookup?title=Eu(III)%20macrocyclic%20complexes%20promote%20cleavage%20of%20and%20bind%20to%20models%20for%20the%205′-cap%20of%20mRNA.%20Effect%20of%20pendent%20group%20and%20a%20second%20metal%20ion&author=D. M. Epstein&author=L. L. Chappell&author=H. Khalili&author=R. M. Supkowski&author=W. W. De Horrocks&author=&author=J. R. Morrow&publication_year=2000" target="_blank">谷歌学术搜索</一个></年代p一个n></li>
<li id="B37">X.-Y。王,j . Zhang k .李et al .,“单核细胞的DNA合成和乳沟活动大环的聚胺锌(II)、铜(II),钴(II)配合物与尿嘧啶,”<gydF4y2Bai>生物有机和药物化学</gydF4y2Bai>,14卷,不。19日,6745 - 6751年,2006页。<年代p一个nclass="reflinks">视图:<一个href="https://doi.org/10.1016/j.bmc.2006.05.049">出版商的网站</一个><年代p一个nclass="sep">|</年代p一个n><一个href="https://scholar.google.com/scholar_lookup?title=Synthesis%20and%20DNA%20cleavage%20activities%20of%20mononuclear%20macrocyclic%20polyamine%20zinc(II),%20copper(II),%20cobalt(II)%20complexes%20which%20linked%20with%20uracil&author=X.-Y. Wang&author=J. Zhang&author=K. Li et al.&publication_year=2006" target="_blank">谷歌学术搜索</一个></年代p一个n></li>
<li id="B38">x b·杨j .冯j . Zhang et al .,“合成、DNA结合和乳沟活动estrogen-macrocyclic铜(II)配合物的聚胺配合,“<gydF4y2Bai>生物有机和药物化学</gydF4y2Bai>,16卷,不。7,3871 - 3877年,2008页。<年代p一个nclass="reflinks">视图:<一个href="https://doi.org/10.1016/j.bmc.2008.01.037">出版商的网站</一个><年代p一个nclass="sep">|</年代p一个n><一个href="https://scholar.google.com/scholar_lookup?title=Synthesis,%20DNA%20binding%20and%20cleavage%20activities%20of%20the%20copper%20(II)%20complexes%20of%20estrogen-macrocyclic%20polyamine%20conjugates&author=X. B. Yang&author=J. Feng&author=J. Zhang et al.&publication_year=2008" target="_blank">谷歌学术搜索</一个></年代p一个n></li>
<li id="B39">r·拉梅什和m . Sivagamasundari合成、光谱和抗真菌活性的俄文(II) mixed-ligand复合物,”<gydF4y2Bai>在无机和有机化学合成和反应性</gydF4y2Bai>,33卷,不。5,899 - 910年,2003页。<年代p一个nclass="reflinks">视图:<一个href="https://doi.org/10.1081/SIM-120021656">出版商的网站</一个><年代p一个nclass="sep">|</年代p一个n><一个href="https://scholar.google.com/scholar_lookup?title=Synthesis,%20spectral,%20and%20antifungal%20activity%20of%20Ru(II)%20mixed-ligand%20complexes&author=R. Ramesh &author=M. Sivagamasundari&publication_year=2003" target="_blank">谷歌学术搜索</一个></年代p一个n></li>
<li id="B40">n . Deligonul m . tum,金丝雀,“合成、表征、催化、电化学、热四齿席夫碱配合物的性质,“<gydF4y2Bai>过渡金属化学</gydF4y2Bai>没有,卷。31日。7,920 - 929年,2006页。<年代p一个nclass="reflinks">视图:<一个href="https://doi.org/10.1007/s11243-006-0087-0">出版商的网站</一个><年代p一个nclass="sep">|</年代p一个n><一个href="https://scholar.google.com/scholar_lookup?title=Synthesis,%20characterization,%20catalytic,%20electrochemical%20and%20thermal%20properties%20of%20tetradentate%20Schiff%20base%20complexes&author=N. Deligönül&author=M. Tümer&author=&author=S. Serin&publication_year=2006" target="_blank">谷歌学术搜索</一个></年代p一个n></li>
<li id="B41">n . Shahabadi s Kashanian, f . Darabi。”<gydF4y2Bai>在体外</gydF4y2Bai>研究DNA相互作用的水溶性分子氮席夫碱,”<gydF4y2Bai>DNA和细胞生物学</gydF4y2Bai>,28卷,不。11日,第596 - 589页,2009年。<年代p一个nclass="reflinks">视图:<一个href="https://doi.org/10.1089/dna.2009.0881">出版商的网站</一个><年代p一个nclass="sep">|</年代p一个n><一个href="https://scholar.google.com/scholar_lookup?title=In%20Vitro%20study%20of%20DNA%20interaction%20with%20a%20water-soluble%20dinitrogen%20schiff%20base&author=N. Shahabadi&author=S. Kashanian&author=&author=F. Darabi&publication_year=2009" target="_blank">谷歌学术搜索</一个></年代p一个n></li>
<li id="B42">b . a . Uzoukwu k .戴手套,h . Duddeck”4-acylpyrazoloneiminjz希夫碱及其金属配合物的合成和光谱研究,“<gydF4y2Bai>在无机和有机化学合成和反应性</gydF4y2Bai>,28卷,不。5,819 - 831年,1998页。<年代p一个nclass="reflinks">视图:<一个href="https://doi.org/10.1080/00945719809349384">出版商的网站</一个><年代p一个nclass="sep">|</年代p一个n><一个href="https://scholar.google.com/scholar_lookup?title=4-acylpyrazoloneiminjz%20Schiff%20bases%20and%20their%20metal%20complexes:%20synthesis%20and%20spectroscopic%20studies&author=B. A. Uzoukwu&author=K. Gloe&author=&author=H. Duddeck&publication_year=1998" target="_blank">谷歌学术搜索</一个></年代p一个n></li>
<li id="B43">j·m·凯利,A . b . Tossi d·j·麦康奈尔和c . Ohuigin”研究的交互polypyridylruthenium (II)配合物与DNA使用荧光光谱,topoisomerisation和热变性,”<gydF4y2Bai>核酸的研究</gydF4y2Bai>,13卷,不。17日,第6034 - 6017页,1985年。<年代p一个nclass="reflinks">视图:<一个href="https://doi.org/10.1093/nar/13.17.6017">出版商的网站</一个><年代p一个nclass="sep">|</年代p一个n><一个href="https://scholar.google.com/scholar_lookup?title=A%20study%20of%20the%20interactions%20of%20some%20polypyridylruthenium(II)%20complexes%20with%20DNA%20using%20fluorescence%20spectroscopy,%20topoisomerisation%20and%20thermal%20denaturation&author=J. M. Kelly&author=A. B. Tossi&author=D. J. Mcconnell&author=&author=C. Ohuigin&publication_year=1985" target="_blank">谷歌学术搜索</一个></年代p一个n></li>
<li id="B44">g·l·伊奇霍恩说和y . a . Shin”相互作用的金属离子分布和相关化合物。十二。各种金属离子的相对影响DNA螺旋性,”<gydF4y2Bai>美国化学学会杂志》上</gydF4y2Bai>,卷90,不。26日,第7328 - 7323页,1968年。<年代p一个nclass="reflinks">视图:<一个href="https://scholar.google.com/scholar_lookup?title=Interaction%20of%20metal%20ions%20with%20polynucleotides%20and%20related%20compounds.%20XII.%20The%20relative%20effect%20of%20various%20metal%20ions%20on%20DNA%20helicity&author=G. L. Eichhorn &author=Y. A. Shin&publication_year=1968" target="_blank">谷歌学术搜索</一个></年代p一个n></li>
<li id="B45">n . Shahabadi s Kashanian m . Khosravi和m . Mahdavi”Multispectroscopic DNA相互作用的研究包含不同的水溶性镍(II)复杂二氮芳香配体,“<gydF4y2Bai>过渡金属化学</gydF4y2Bai>,35卷,不。6,699 - 705年,2010页。<年代p一个nclass="reflinks">视图:<一个href="https://doi.org/10.1007/s11243-010-9382-x">出版商的网站</一个><年代p一个nclass="sep">|</年代p一个n><一个href="https://scholar.google.com/scholar_lookup?title=Multispectroscopic%20DNA%20interaction%20studies%20of%20a%20water-soluble%20nickel(II)%20complex%20containing%20different%20dinitrogen%20aromatic%20ligands&author=N. Shahabadi&author=S. Kashanian&author=M. Khosravi&author=&author=M. Mahdavi&publication_year=2010" target="_blank">谷歌学术搜索</一个></年代p一个n></li>
<li id="B46">马哈德文和m . Palaniandavar“光谱和伏安研究铜配合物2、9-dimethyl-1, 10-phenanthrolines绑定到小牛胸腺DNA,”<gydF4y2Bai>无机化学</gydF4y2Bai>,37卷,不。4、693 - 700年,1998页。<年代p一个nclass="reflinks">视图:<一个href="https://scholar.google.com/scholar_lookup?title=Spectroscopic%20and%20voltammetric%20studies%20on%20copper%20complexes%20of%202,9-dimethyl-1,10-phenanthrolines%20bound%20to%20calf%20thymus%20DNA&author=S. Mahadevan &author=M. Palaniandavar&publication_year=1998" target="_blank">谷歌学术搜索</一个></年代p一个n></li>
<li id="B47">p·乌玛Maheswari和m . Palaniandavar DNA结合和乳沟属性的某些tetrammine钌(II)配合物1,修改10-phenanthrolines-effect氢键的DNA结合蛋白亲和力,”<gydF4y2Bai>无机生物化学杂志》上</gydF4y2Bai>,卷98,不。2、219 - 230年,2004页。<年代p一个nclass="reflinks">视图:<一个href="https://doi.org/10.1016/j.jinorgbio.2003.09.003">出版商的网站</一个><年代p一个nclass="sep">|</年代p一个n><一个href="https://scholar.google.com/scholar_lookup?title=DNA%20binding%20and%20cleavage%20properties%20of%20certain%20tetrammine%20ruthenium(II)%20complexes%20of%20modified%201,10-phenanthrolines—effect%20of%20hydrogen-bonding%20on%20DNA-binding%20affinity&author=P. Uma Maheswari &author=M. Palaniandavar&publication_year=2004" target="_blank">谷歌学术搜索</一个></年代p一个n></li>
<li id="B48">m . r . Eftink和c . a . Ghiron”与蛋白质荧光猝灭的研究”,<gydF4y2Bai>分析生物化学</gydF4y2Bai>,卷114,不。2、199 - 227年,1981页。<年代p一个nclass="reflinks">视图:<一个href="https://scholar.google.com/scholar_lookup?title=Fluorescence%20quenching%20studies%20with%20proteins&author=M. R. Eftink &author=C. A. Ghiron&publication_year=1981" target="_blank">谷歌学术搜索</一个></年代p一个n></li>
<li id="B49">h . b . Peng曹国伟,b .太阳,h . Li f·高和L.-N。霁”、合成、dna结合蛋白和photocleavage研究钴(III) mixed-polypyridyl复合物:[有限公司(苯酚的)<年代ub>2</年代ub>(dpta)]<年代up>3 +</年代up>和[公司(苯酚的)<年代ub>2</年代ub>(amtp)]<年代up>3 +</年代up>”,<gydF4y2Bai>无机生物化学杂志》上</gydF4y2Bai>,卷101,不。3、404 - 411年,2007页。<年代p一个nclass="reflinks">视图:<一个href="https://doi.org/10.1016/j.jinorgbio.2006.11.008">出版商的网站</一个><年代p一个nclass="sep">|</年代p一个n><一个href="https://scholar.google.com/scholar_lookup?title=Synthesis,%20DNA-binding%20and%20photocleavage%20studies%20of%20cobalt(III)%20mixed-polypyridyl%20complexes:%20[Co(phen)2(dpta)]3+%20and%20[Co(phen)2(amtp)]3+&author=B. Peng&author=H. Chao&author=B. Sun&author=H. Li&author=F. Gao&author=&author=L.-N. Ji&publication_year=2007" target="_blank">谷歌学术搜索</一个></年代p一个n></li>
<li id="B50">v . g . Vaidyanathan和b Nair,“光致氧化钴(II)的DNA有三叉的复杂,“<gydF4y2Bai>无机生物化学杂志》上</gydF4y2Bai>,卷94,不。1 - 2、121 - 126年,2003页。<年代p一个nclass="reflinks">视图:<一个href="https://doi.org/10.1016/S0162-0134(02)00620-7">出版商的网站</一个><年代p一个nclass="sep">|</年代p一个n><一个href="https://scholar.google.com/scholar_lookup?title=Photooxidation%20of%20DNA%20by%20a%20cobalt(II)%20tridentate%20complex&author=V. G. Vaidyanathan &author=B. U. Nair&publication_year=2003" target="_blank">谷歌学术搜索</一个></年代p一个n></li>
<li id="B51">y太阳,Bi, d .歌曲,c·乔dμ,h·张,“DNA之间的相互作用机理,研究黄芩的主要有效成分,”<gydF4y2Bai>传感器和执行器,B</gydF4y2Bai>,卷129,不。2、799 - 810年,2008页。<年代p一个nclass="reflinks">视图:<一个href="https://doi.org/10.1016/j.snb.2007.09.082">出版商的网站</一个><年代p一个nclass="sep">|</年代p一个n><一个href="https://scholar.google.com/scholar_lookup?title=Study%20on%20the%20interaction%20mechanism%20between%20DNA%20and%20the%20main%20active%20components%20in%20Scutellaria%20baicalensis%20Georgi&author=Y. Sun&author=S. Bi&author=D. Song&author=C. Qiao&author=D. Mu&author=&author=H. Zhang&publication_year=2008" target="_blank">谷歌学术搜索</一个></年代p一个n></li>
<li id="B52">F.-L。崔,j .风扇的j。李,Z.-D。胡,”1-benzoyl-4——之间的相互作用<gydF4y2Bai>p</gydF4y2Bai>-chlorophenyl氨基硫脲和血清白蛋白:荧光光谱的调查。”<gydF4y2Bai>生物有机和药物化学</gydF4y2Bai>,12卷,不。1,第157 - 151页,2004。<年代p一个nclass="reflinks">视图:<一个href="https://doi.org/10.1016/j.bmc.2003.10.018">出版商的网站</一个><年代p一个nclass="sep">|</年代p一个n><一个href="https://scholar.google.com/scholar_lookup?title=Interactions%20between%201-benzoyl-4-p-chlorophenyl%20thiosemicarbazide%20and%20serum%20albumin:%20investigation%20by%20fluorescence%20spectroscopy&author=F.-L. Cui&author=J. Fan&author=J.-P. Li&author=&author=Z.-D. Hu&publication_year=2004" target="_blank">谷歌学术搜索</一个></年代p一个n></li>
<li id="B53">p·b·Kandagal s m t·谢赫·d·h·Manjunatha j . Seetharamappa和b s Nagaralli“光谱研究生物活性吩噻嗪化合物的结合人类血清白蛋白,”<gydF4y2Bai>光化学、光生物学杂志》上</gydF4y2Bai>,卷189,不。1,第127 - 121页,2007。<年代p一个nclass="reflinks">视图:<一个href="https://doi.org/10.1016/j.jphotochem.2007.01.021">出版商的网站</一个><年代p一个nclass="sep">|</年代p一个n><一个href="https://scholar.google.com/scholar_lookup?title=Spectroscopic%20studies%20on%20the%20binding%20of%20bioactive%20phenothiazine%20compounds%20to%20human%20serum%20albumin&author=P. B. Kandagal&author=S. M. T. Shaikh&author=D. H. Manjunatha&author=J. Seetharamappa&author=&author=B. S. Nagaralli&publication_year=2007" target="_blank">谷歌学术搜索</一个></年代p一个n></li>
<li id="B54">m .江M.-X。谢,d .郑y . Liu X.-Y。”李、陈x光谱研究肉桂酸之间的相互作用及其与人血清白蛋白,羟基衍生品”<gydF4y2Bai>杂志的分子结构</gydF4y2Bai>,卷692,不。1 - 3、71 - 80年,2004页。<年代p一个nclass="reflinks">视图:<一个href="https://doi.org/10.1016/j.molstruc.2004.01.003">出版商的网站</一个><年代p一个nclass="sep">|</年代p一个n><一个href="https://scholar.google.com/scholar_lookup?title=Spectroscopic%20studies%20on%20the%20interaction%20of%20cinnamic%20acid%20and%20its%20hydroxyl%20derivatives%20with%20human%20serum%20albumin&author=M. Jiang&author=M.-X. Xie&author=D. Zheng&author=Y. Liu&author=X.-Y. Li&author=&author=X. Chen&publication_year=2004" target="_blank">谷歌学术搜索</一个></年代p一个n></li>
<li id="B55">m .江M.-X。谢,d .郑y . Liu X.-Y。”李、陈x光谱研究肉桂酸之间的相互作用及其与人血清白蛋白,羟基衍生品”<gydF4y2Bai>杂志的分子结构</gydF4y2Bai>,卷692,不。1 - 3、71 - 80年,2004页。<年代p一个nclass="reflinks">视图:<一个href="https://doi.org/10.1016/j.molstruc.2004.01.003">出版商的网站</一个><年代p一个nclass="sep">|</年代p一个n><一个href="https://scholar.google.com/scholar_lookup?title=Spectroscopic%20studies%20on%20the%20interaction%20of%20cinnamic%20acid%20and%20its%20hydroxyl%20derivatives%20with%20human%20serum%20albumin&author=M. Jiang&author=M.-X. Xie&author=D. Zheng&author=Y. Liu&author=X.-Y. Li&author=&author=X. Chen&publication_year=2004" target="_blank">谷歌学术搜索</一个></年代p一个n></li>
<li id="B56">n Shahabadi和a . Fatahi Multispectroscopic dna结合蛋白的研究包含4 tris-chelate镍(II)复杂,7-diphenyl 1, 10-phenanthroline配体,“<gydF4y2Bai>杂志的分子结构</gydF4y2Bai>,卷970,不。1 - 3、90 - 95年,2010页。<年代p一个nclass="reflinks">视图:<一个href="https://doi.org/10.1016/j.molstruc.2010.02.048">出版商的网站</一个><年代p一个nclass="sep">|</年代p一个n><一个href="https://scholar.google.com/scholar_lookup?title=Multispectroscopic%20DNA-binding%20studies%20of%20a%20tris-chelate%20nickel(II)%20complex%20containing%204,7-diphenyl%201,10-phenanthroline%20ligands&author=N. Shahabadi &author=A. Fatahi&publication_year=2010" target="_blank">谷歌学术搜索</一个></年代p一个n></li>
<li id="B57">r·f·Pasternack e·j·吉布斯和j·j . Villafranca“卟啉与核酸的相互作用,”<gydF4y2Bai>生物化学</gydF4y2Bai>,22卷,不。10日,2406 - 2414年,1983页。<年代p一个nclass="reflinks">视图:<一个href="https://scholar.google.com/scholar_lookup?title=Interactions%20of%20porphyrins%20with%20nucleic%20acids&author=R. F. Pasternack&author=E. J. Gibbs&author=&author=J. J. Villafranca&publication_year=1983" target="_blank">谷歌学术搜索</一个></年代p一个n></li>
<li id="B58">马哈德文和m . Palaniandavar“光谱和伏安研究铜配合物2、9-dimethyl-1, 10-phenanthrolines绑定到小牛胸腺DNA,”<gydF4y2Bai>无机化学</gydF4y2Bai>,37卷,不。4、693 - 700年,1998页。<年代p一个nclass="reflinks">视图:<一个href="https://scholar.google.com/scholar_lookup?title=Spectroscopic%20and%20voltammetric%20studies%20on%20copper%20complexes%20of%202,9-dimethyl-1,10-phenanthrolines%20bound%20to%20calf%20thymus%20DNA&author=S. Mahadevan &author=M. Palaniandavar&publication_year=1998" target="_blank">谷歌学术搜索</一个></年代p一个n></li>
<li id="B59">s . Kashanian m . b . Gholivand f·艾哈迈迪,a . Taravati和a . h . Colagar”与Al - DNA交互<gydF4y2Bai>N, N</gydF4y2Bai>- - - - - -<gydF4y2Bai>国际清算银行</gydF4y2Bai>(salicylidene) 2, 2′-phenylendiamine复杂,“<gydF4y2Bai>Spectrochimica Acta-Part一</gydF4y2Bai>,卷67,不。2、472 - 478年,2007页。<年代p一个nclass="reflinks">视图:<一个href="https://doi.org/10.1016/j.saa.2006.08.017">出版商的网站</一个><年代p一个nclass="sep">|</年代p一个n><一个href="https://scholar.google.com/scholar_lookup?title=DNA%20interaction%20with%20Al-N,N-bis%20(salicylidene)2,2′-phenylendiamine%20complex&author=S. Kashanian&author=M. B. Gholivand&author=F. Ahmadi&author=A. Taravati&author=&author=A. H. Colagar&publication_year=2007" target="_blank">谷歌学术搜索</一个></年代p一个n></li>
<li id="B60">a·沃尔夫·g·h·垫片Jr .)和t .米,“多环芳烃物理变性DNA插入到双地区,”<gydF4y2Bai>生物化学</gydF4y2Bai>,26卷,不。20日,第6396 - 6392页,1987年。<年代p一个nclass="reflinks">视图:<一个href="https://scholar.google.com/scholar_lookup?title=Polycyclic%20aromatic%20hydrocarbons%20physically%20intercalate%20into%20duplex%20regions%20of%20denatured%20DNA&author=A. Wolfe&author=G. H. Shimer Jr.&author=&author=T. Meehan&publication_year=1987" target="_blank">谷歌学术搜索</一个></年代p一个n></li>
<li id="B61">m·科里·d·d·麦基j·卡根,d . w·亨利和j·a·米勒”,设计、合成和双官能intercalators的DNA结合特性。比较聚亚甲基二苯醚链连接菲啶,”<gydF4y2Bai>美国化学学会杂志》上</gydF4y2Bai>,卷107,不。8,2528 - 2536年,1985页。<年代p一个nclass="reflinks">视图:<一个href="https://scholar.google.com/scholar_lookup?title=Design,%20synthesis,%20and%20DNA%20binding%20properties%20of%20bifunctional%20intercalators.%20Comparison%20of%20polymethylene%20and%20diphenyl%20ether%20chains%20connecting%20phenanthridine&author=M. Cory&author=D. D. McKee&author=J. Kagan&author=D. W. Henry&author=&author=J. A. Miller&publication_year=1985" target="_blank">谷歌学术搜索</一个></年代p一个n></li>
<li id="B62">m . j .华林”复杂的溴化乙锭和核酸之间形成,”<gydF4y2Bai>分子生物学杂志</gydF4y2Bai>,13卷,不。1,第282 - 269页,1965。<年代p一个nclass="reflinks">视图:<一个href="https://scholar.google.com/scholar_lookup?title=Complex%20formation%20between%20ethidium%20bromide%20and%20nucleic%20acids&author=M. J. Waring&publication_year=1965" target="_blank">谷歌学术搜索</一个></年代p一个n></li>
<li id="B63">v . g . Vaidyanathan和b Nair,“光致氧化钴(II)的DNA有三叉的复杂,“<gydF4y2Bai>无机生物化学杂志》上</gydF4y2Bai>,卷94,不。1 - 2、121 - 126年,2003页。<年代p一个nclass="reflinks">视图:<一个href="https://doi.org/10.1016/S0162-0134(02)00620-7">出版商的网站</一个><年代p一个nclass="sep">|</年代p一个n><一个href="https://scholar.google.com/scholar_lookup?title=Photooxidation%20of%20DNA%20by%20a%20cobalt(II)%20tridentate%20complex&author=V. G. Vaidyanathan &author=B. U. Nair&publication_year=2003" target="_blank">谷歌学术搜索</一个></年代p一个n></li>
<li id="B64">s . Arounaguiri d . Easwaramoorthy a . Ashokkumar a . Dattagupta和b . g . Maiya”(III)钴、镍(II)和钌(II)配合物1,10-phenanthroline家族的配体:DNA结合和photocleavage研究,“<gydF4y2Bai>印度科学院学报》:化学科学</gydF4y2Bai>,卷112,不。1,1卷,2000页。<年代p一个nclass="reflinks">视图:<一个href="https://scholar.google.com/scholar_lookup?title=Cobalt(III),%20nickel(II)%20and%20ruthenium(II)%20complexes%20of%201,10-phenanthroline%20family%20of%20ligands:%20DNA%20binding%20and%20photocleavage%20studies&author=S. Arounaguiri&author=D. Easwaramoorthy&author=A. Ashokkumar&author=A. Dattagupta&author=&author=B. G. Maiya&publication_year=2000" target="_blank">谷歌学术搜索</一个></年代p一个n></li>
<li id="B65">T.-R。李,Z.-Y。杨,B.-D。王,D.-D。秦”、合成、表征、抗氧化活性和dna结合蛋白的研究两个稀土(III)复合物naringenin-2-hydroxy苯甲酰腙配体,“<gydF4y2Bai>欧洲药物化学杂志》上</gydF4y2Bai>,43卷,不。8,1688 - 1695年,2008页。<年代p一个nclass="reflinks">视图:<一个href="https://doi.org/10.1016/j.ejmech.2007.10.006">出版商的网站</一个><年代p一个nclass="sep">|</年代p一个n><一个href="https://scholar.google.com/scholar_lookup?title=Synthesis,%20characterization,%20antioxidant%20activity%20and%20DNA-binding%20studies%20of%20two%20rare%20earth(III)%20complexes%20with%20naringenin-2-hydroxy%20benzoyl%20hydrazone%20ligand&author=T.-R. Li&author=Z.-Y. Yang&author=B.-D. Wang&author=&author=D.-D. Qin&publication_year=2008" target="_blank">谷歌学术搜索</一个></年代p一个n></li>
<li id="B66">p .乌玛Maheswari诉Rajendiran m . Palaniandavar r·托马斯和g Kulkarni”混合配体钌(II)配合物5,6-dimethyl-1, 10-phenanthroline:配体的作用疏水性的DNA结合复合物,”<gydF4y2Bai>Inorganica Chimica学报</gydF4y2Bai>,卷359,不。14日,第4612 - 4601页,2006年。<年代p一个nclass="reflinks">视图:<一个href="https://doi.org/10.1016/j.ica.2006.07.053">出版商的网站</一个><年代p一个nclass="sep">|</年代p一个n><一个href="https://scholar.google.com/scholar_lookup?title=Mixed%20ligand%20ruthenium(II)%20complexes%20of%205,6-dimethyl-1,10-phenanthroline:%20the%20role%20of%20ligand%20hydrophobicity%20on%20DNA%20binding%20of%20the%20complexes&author=P. Uma Maheswari&author=V. Rajendiran&author=M. Palaniandavar&author=R. Thomas&author=&author=G. U. Kulkarni&publication_year=2006" target="_blank">谷歌学术搜索</一个></年代p一个n></li>
<li id="B67">j .太阳,吴,y . et al .,“合成、晶体结构和钌(II)的dna结合特性polypyridyl复合物与dicationic 2, 2′联吡啶衍生物为配体,“<gydF4y2Bai>多面体</gydF4y2Bai>,27卷,不。13日,2845 - 2850年,2008页。<年代p一个nclass="reflinks">视图:<一个href="https://doi.org/10.1016/j.poly.2008.06.009">出版商的网站</一个><年代p一个nclass="sep">|</年代p一个n><一个href="https://scholar.google.com/scholar_lookup?title=Synthesis,%20crystal%20structure%20and%20DNA-binding%20properties%20of%20ruthenium(II)%20polypyridyl%20complexes%20with%20dicationic%202,2′-dipyridyl%20derivatives%20as%20ligands&author=J. Sun&author=S. Wu&author=Y. An et al.&publication_year=2008" target="_blank">谷歌学术搜索</一个></年代p一个n></li>
<li id="B68">沙玛,s . k·辛格·m·钱德拉和d s Pandey,“dna结合蛋白的行为钌(II)配合物包含两组15捐赠者和2,2′,6′,2′′-terpyridine,”<gydF4y2Bai>无机生物化学杂志》上</gydF4y2Bai>,卷99,不。2、458 - 466年,2005页。<年代p一个nclass="reflinks">视图:<一个href="https://doi.org/10.1016/j.jinorgbio.2004.10.021">出版商的网站</一个><年代p一个nclass="sep">|</年代p一个n><一个href="https://scholar.google.com/scholar_lookup?title=DNA-binding%20behavior%20of%20ruthenium(II)%20complexes%20containing%20both%20group%2015%20donors%20and%202,2′:6′,2′′-terpyridine&author=S. Sharma&author=S. K. Singh&author=M. Chandra&author=&author=D. S. Pandey&publication_year=2005" target="_blank">谷歌学术搜索</一个></年代p一个n></li>
<li id="B69">X.-L。李h .曹国伟,h . et al .,“DNA的相互作用(3)mixed-polypyridyl钴复合物含有不对称的配体,“<gydF4y2Bai>无机生物化学杂志》上</gydF4y2Bai>,卷98,不。6,1143 - 1150年,2004页。<年代p一个nclass="reflinks">视图:<一个href="https://doi.org/10.1016/j.jinorgbio.2004.04.003">出版商的网站</一个><年代p一个nclass="sep">|</年代p一个n><一个href="https://scholar.google.com/scholar_lookup?title=DNA%20interactions%20of%20cobalt(III)%20mixed-polypyridyl%20complexes%20containing%20asymmetric%20ligands&author=X.-L. Wang&author=H. Chao&author=H. Li et al.&publication_year=2004" target="_blank">谷歌学术搜索</一个></年代p一个n></li>
<li id="B70">Q.-L。张,J.-G。刘,刘j . et al .,“dna结合蛋白和photocleavage钴的研究(3)mixed-polypyridyl复合物含有2 - (2-chloro-5-nitrophenyl)咪唑并[4,5 -<gydF4y2Bai>f</gydF4y2Bai>][1,10]邻二氮杂菲。”<gydF4y2Bai>无机生物化学杂志》上</gydF4y2Bai>,卷85,不。4、291 - 296年,2001页。<年代p一个nclass="reflinks">视图:<一个href="https://doi.org/10.1016/S0162-0134(01)00212-4">出版商的网站</一个><年代p一个nclass="sep">|</年代p一个n><一个href="https://scholar.google.com/scholar_lookup?title=DNA-binding%20and%20photocleavage%20studies%20of%20cobalt(III)%20mixed-polypyridyl%20complexes%20containing%202-(2-chloro-5-nitrophenyl)imidazo%20[4,5-f][1,10]phenanthroline&author=Q.-L. Zhang&author=J.-G. Liu&author=J. Liu et al.&publication_year=2001" target="_blank">谷歌学术搜索</一个></年代p一个n></li>
<li id="B71">d·h·约翰斯顿、k·c·格拉斯哥和h·h·索普,“电化学测试溶剂可及性的碱基使用DNA和金属配合物之间的电子转移,”<gydF4y2Bai>美国化学学会杂志》上</gydF4y2Bai>,卷117,不。35岁,8933 - 8938年,1995页。<年代p一个nclass="reflinks">视图:<一个href="https://scholar.google.com/scholar_lookup?title=Electrochemical%20measurement%20of%20the%20solvent%20accessibility%20of%20nucleobases%20using%20electron%20transfer%20between%20DNA%20and%20metal%20complexes&author=D. H. Johnston&author=K. C. Glasgow&author=&author=H. H. Thorp&publication_year=1995" target="_blank">谷歌学术搜索</一个></年代p一个n></li>
<li id="B72">r . Indumathy完婚,m . Kanthimathi t . Weyhermuller, b .乌尼Nair”terpyridine配体的钴配合物:晶体结构和photocleavage DNA”<gydF4y2Bai>无机生物化学杂志》上</gydF4y2Bai>,卷101,不。3、434 - 443年,2007页。<年代p一个nclass="reflinks">视图:<一个href="https://doi.org/10.1016/j.jinorgbio.2006.11.002">出版商的网站</一个><年代p一个nclass="sep">|</年代p一个n><一个href="https://scholar.google.com/scholar_lookup?title=Cobalt%20complexes%20of%20terpyridine%20ligand:%20crystal%20structure%20and%20photocleavage%20of%20DNA&author=R. Indumathy&author=S. Radhika&author=M. Kanthimathi&author=T. Weyhermuller&author=&author=B. Unni Nair&publication_year=2007" target="_blank">谷歌学术搜索</一个></年代p一个n></li>
<li id="B73">p . j . y . m .歌问:Wu, n . n .烹调的菜肴和y . m . Liu l . f . Wang”DNA结合和分裂活动的镍(II)复杂all-trans视黄酸,”<gydF4y2Bai>无机生物化学杂志》上</gydF4y2Bai>,卷100,不。10日,1685 - 1691年,2006页。<年代p一个nclass="reflinks">视图:<一个href="https://doi.org/10.1016/j.jinorgbio.2006.06.001">出版商的网站</一个><年代p一个nclass="sep">|</年代p一个n><一个href="https://scholar.google.com/scholar_lookup?title=DNA%20Binding%20and%20cleavage%20activity%20of%20Ni(II)%20complex%20with%20all-trans%20retinoic%20acid&author=Y. M. Song&author=Q. Wu&author=P. J. Yang&author=N. N. Luan&author=L. F. Wang&author=&author=Y. M. Liu&publication_year=2006" target="_blank">谷歌学术搜索</一个></年代p一个n></li>
<li id="B74">问:冯,N.-Q。李,y y。江”,电化学的研究卟啉与DNA的DNA和决心,互动”<gydF4y2Bai>分析Chimica学报</gydF4y2Bai>,卷344,不。1 - 2、97 - 104年,1997页。<年代p一个nclass="reflinks">视图:<一个href="https://doi.org/10.1016/S0003-2670(97)00008-1">出版商的网站</一个><年代p一个nclass="sep">|</年代p一个n><一个href="https://scholar.google.com/scholar_lookup?title=Electrochemical%20studies%20of%20porphyrin%20interacting%20with%20DNA%20and%20determination%20of%20DNA&author=Q. Feng&author=N.-Q. Li&author=&author=Y.-Y. Jiang&publication_year=1997" target="_blank">谷歌学术搜索</一个></年代p一个n></li>
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<p>版权©2012 Nahid Shahabadi等。这是一个开放的分布式下文章<一个rel="license" href="http://creativecommons.org/licenses/by/3.0/">知识共享归属许可</一个>,它允许无限制的使用、分配和复制在任何媒介,提供最初的工作是正确引用。</p></gydF4y2Badiv>
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<div class="sc-hBbWxd kdRRST">
<div class="sc-dyGzUR cHatnS">
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的观点<年代p一个n>2983年年</年代p一个n></div>
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下载<年代p一个n>1592年年</年代p一个n></div>
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<div class="sc-drKuOJ kxdGAZ">
<span class="__dimensions_badge_embed__" data-doi="10.1155/2012/126451" data-style="small_circle"></span>引用</gydF4y2Badiv>
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