TY - JOUR A2 - Lewis, George K. AU - Oufir, Mouhssin AU - Bisset, Leslie R. AU - Hoffmann, Stefan R. K. AU - Xue, Gongda AU - Klauser, Stephan AU - Bergamaschi, Bianca AU - Gervaix, Alain AU - Böni, Jürg AU - Schüpbach, Jörg AU - Gutte，Bernd PY - 2011 DA - 2011/09/19 TI -人工64 -残渣hiv - 1 Enhancer-Binding肽是一种病毒复制的有效抑制剂HIV-1-Infected细胞SP - 165871年重要的hiv - 1 - 2011 AB -人造Enhancer-Binding肽是延长连续九年精氨酸残基的糖和核本地化SV40大的信号T antigen at the N-terminus. The resulting synthetic 64-residue peptide was found to bind to the two enhancers of the HIV-1 long terminal repeat, cross the plasma membrane and the nuclear envelope of human cells, and suppress the HIV-1 enhancer-controlled expression of a green fluorescent protein reporter gene. Moreover, HIV-1 replication is inhibited by this peptide in HIV-1-infected CEM-GFP cells as revealed by HIV-1 p24 ELISA and real-time RT-PCR of HIV-1 RNA. Rapid uptake of this intracellular stable and inhibitory peptide into the cells implies that this peptide may have the potential to attenuate HIV-1 replication 在活的有机体内．SN - 1687-8639 UR - https://doi.org/10.1155/2011/165871 DO - 10.1155/2011/165871 JF - Advances in Virology PB - Hindawi Publishing Corporation KW - ER -