TY - JOUR A2 - Nelson, Colleen AU - Azzouni, Faris AU - Godoy, Alejandro AU - Li, Yun AU - Mohler, James PY - 2012 DA - 2011/12/25 TI - The 5 Alpha-Reductase Isozyme Family: A Review of Basic Biology and Their Role in Human Diseases SP - 530121 VL - 2012 AB - Despite the discovery of 5 alpha-reduction as an enzymatic step in steroid metabolism in 1951, and the discovery that dihydrotestosterone is more potent than testosterone in 1968, the significance of 5 alpha-reduced steroids in human diseases was not appreciated until the discovery of 5 alpha-reductase type 2 deficiency in 1974.受到影响的雄性生出模异外生殖器,尽管内部生殖器正常前列腺有虚构性,直肠检查不可插动,约1/10本尼德前列腺增生或前列腺癌在这些病人中不发展青春期外生殖器部分精锐化,然而二级性毛仍然稀疏,男性模式秃头和Acne很少开发数种复合物开发抑制5A+Zymes并在许多常见疾病的预防和治疗中发挥重要作用本审查描述基本生化属性、函数、组织分布、染色体定位和5A-反射子系的临床意义SN-1687-6369UR-https://doi.org/101155/2012/530121DO-10.1155/2012/530121JF-UrlogyPB-Hindawi出版公司KW-ER