Ty - Jour A2 - Ferrer-Montiel，Antonio Au - Smutzer，Gregory Au - Devassy，Roni K. Py - 2016 DA - 2016/01/14 TI - 集成TRPV1受体功能与Capsaicin Psychocophysics SP - 1512457 VL - 2016 AB - Capsaicin是一种天然存在的香草，导致人口腔中的热刺激性感。该三叉刺激激活TRPV1受体并刺激阳离子的涌入感应细胞。TRPV1受体用作同种带也可以响应热，促炎物质，脂氧合酶产物，树脂胶毒素，内荷芳脂糖，质子和肽毒素的同源体。激酶介导的TRPV1的磷酸化导致对化学和热刺激的敏感性增加。相反，脱敏通过钙依赖性机制发生，导致受体去磷酸化。人类的心理物理学研究表明，在纳米摩量时检测辣椒素，并在口腔中导致脱敏。心理物理学研究进一步表明，如果用短期内的间隔恢复辣椒素的刺激，则脱敏可以在口腔中暂时逆转。用辣椒素的预处理调节了几种主要品味品质的感知。此外，甜味刺激可能会降低口腔中辣椒素感知的强度。 In addition, capsaicin perception and hedonic responses may be modified by diet. Psychophysical studies with capsaicin are consistent with recent findings that have identified TRPV1 channel modulation by phosphorylation and interactions with membrane inositol phospholipids. Future studies will further clarify the importance of capsaicin and its receptor in human health and nutrition. SN - 2633-4682 UR - https://doi.org/10.1155/2016/1512457 DO - 10.1155/2016/1512457 JF - Advances in Pharmacological Sciences PB - Hindawi Publishing Corporation KW - ER -