TY -的A2 -澳特斯,埃斯特拉m . AU - Hamdy莫娜盟——Salama Niveen AU -马赫,葛盟——Elrefaee阿米拉PY - 2018 DA - 2018/09/16 TI -维生素D和Nonskeletal并发症在埃及镰状细胞病病人SP - 3867283六世- 2018 AB -低水平的维生素D已记录在许多患有镰状细胞病(SCD),但关于维生素D缺乏(VDD)和各种SCD并发症的发生或严重程度之间的关系，数据仍不确定。我们的研究旨在检测埃及SCD患者中维生素D缺乏的患病率，并将其与疾病的临床病程联系起来。我们使用酶联免疫吸附试验测量了140名儿童(年龄从4.3岁到15.5岁)、80名SCD患者和60名对照者的25-羟基维生素D水平。60%的SCD患者缺乏维生素D，而对照组为26.7%。SCD患者重度VDD明显高于对照组。将患者分为2组;正常组32例，虚组48例。两组在年龄、身高百分位数、临床黄疸有无和骨性改变方面差异有统计学意义(P值分别为0.043、0.024、0.001和0.015)。缺陷组血红蛋白和红细胞压积显著降低(P值分别为0.022和0.004)，天冬氨酸转氨酶、乳酸脱氢酶、总胆红素和间接胆红素水平显著升高(P值分别为0.006、0.001、0.038和0.016)。 The frequency of blood transfusions, hospitalization, and vasoocclusive crisis previous year as well as the history of bone fracture and recurrent infections proved to be significantly higher in Deficient group. These findings suggest that VDD may play a role in the pathogenesis of hemolysis and other complication of SCD. Vitamin D monitoring and supplementation in patients with SCD should be implemented as a standard of care to potentially improve health outcomes in these affected patients. SN - 1687-9104 UR - https://doi.org/10.1155/2018/3867283 DO - 10.1155/2018/3867283 JF - Advances in Hematology PB - Hindawi KW - ER -