TY - JOUR A2 - Albitar, Maher AU - Molica, Stefano AU - Digiesi, Giovanna AU - Vacca, Angelo AU - Mirabelli, Rosanna AU - Todoerti, Katia AU - Battaglia, Caterina AU - Morabito, Fortunato AU - Neri, Antonino AU - Ribatti, Domenico PY - 2009 DA - 2009/08/27 TI - Does Adiponectin Act as an Antiangiogenic Factor in B-Cell Chronic Lymphocytic Leukemia? SP - 287974 VL - 2009 AB - Angiogenesis is involved in the pathogenesis of B-cell chronic lymphocytic leukemia (CLL), and high microvascular density has been found in CLL to be associated with a poor prognosis. In this study, we assessed serum levels of adiponectin in 69 patients with Binet stage A B-CLL, and these values were retrospectively correlated with bone marrow (BM) microvessel area and serum levels of vascular endothelial growth factor (VEGF), fibroblast growth factor-2 (FGF-2), angiogenin, PECAM-1 (CD31), matrix metalloproteinase-9 (MMP-9), interleukin-8 (IL-8), syndecan-1, and the percentage of CD 38 + or ZAP- 70 + CLL cells. The positive correlation between serum levels of adiponectin and VEGF ( P = .03 ) does not translate into an increase of the extent of BM angiogenesis ( P = .404 ), FGF-2 ( P = .348 ), angiogenin ( P = .402 ), and CD31 ( P = .248 ) serum concentrations. Accordingly, IL-8 ( P = .175 ), syndecan-1 ( P = .06 ), and MMP-9 ( P = .144 ) circulating levels were not likely to reflect adiponectin concentration. Furthermore, patients with higher levels of adiponectin had a more favorable biological profile as defined by a lower number of both CD 38 − ( r = − 0.294 ; P = .02 ) and ZAP- 70 + ( r = − 0.285 ; P = .04 ). Finally, we evaluated the presence of adiponectin in B-CLL cells at gene expression level. RMA intensity values for adiponectin gene transcript denote a homogeneous low expression in B-CLL cells, whereas VEGF transcript was highly expressed with a degree of interpatient variability. Overall, these data seem to indicate that adiponectin could be involved as an antiangiogenic factor in B-CLL. SN - 1687-9104 UR - https://doi.org/10.1155/2009/287974 DO - 10.1155/2009/287974 JF - Advances in Hematology PB - Hindawi Publishing Corporation KW - ER -